Product image of Levetiracetam Accord (Levetiracetam) supplied by GNH India

Levetiracetam Accord

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord, is an anticonvulsant presented as an intravenous solution for intravenous use. It is indicated for the treatment of partial seizures, generalized tonic‑clonic seizures and myoclonic seizures in patients with epilepsy.

GNH India supplies Levetiracetam Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution across EU and other global markets. The company adheres to stringent quality standards and provides regulatory support for import and clinical use throughout.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

  • Levetiracetam is an anticonvulsant used to control seizure activity in epilepsy.
  • Partial seizures: reduces frequency of focal onset seizures
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes
  • Myoclonic seizures: decreases myoclonic jerks

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and reducing neuronal hyper‑excitability. This interaction stabilizes synaptic transmission and diminishes the propagation of epileptic discharges without significant effects on ion channels or G‑protein pathways. The drug’s high affinity for SV2A leads to a decrease in calcium‑dependent vesicle exocytosis, thereby limiting the excessive firing of neurons that underlies seizure activity.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness
  • Somnolence: increased sleepiness or fatigue
  • Headache: mild to moderate cranial pain
  • Irritability: mood changes or agitation

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or anaphylaxis
  • Psychiatric disturbances: depression, suicidal thoughts, or aggressive behavior
  • Blood disorders: thrombocytopenia or neutropenia

Precautions & Warnings

  • When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure safe use.
  • Renal function: adjust dosing in patients with impaired renal clearance.
  • Pregnancy: potential risks are unknown; weigh benefits against possible fetal exposure.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Mood changes: observe for new or worsening psychiatric symptoms.
  • Discontinuation: taper gradually to avoid seizure recurrence.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine, phenytoin, phenobarbital: may lower levetiracetam plasma concentrations.
  • Live vaccines: reduced vaccine efficacy may occur.

Moderate Interactions (Monitor Closely)

  • Alcohol: may increase central nervous system depression.
  • Other antiepileptic drugs: may require dose adjustments.
  • Renally toxic agents: monitor renal function closely when co‑administered.

Frequently Asked Questions

Levetiracetam Accord is an intravenous formulation of levetiracetam indicated for the treatment of epilepsy. It is prescribed to control partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients who require rapid or controlled delivery of the medication via the bloodstream.

Levetiracetam exerts its antiepileptic effect by binding to the synaptic vesicle protein SV2A. This binding modulates neurotransmitter release, reduces calcium‑dependent vesicle exocytosis, and stabilizes neuronal firing, thereby decreasing the hyper‑excitability that leads to seizure activity.

The dosage of Levetiracetam Accord is individualized. A qualified prescriber determines the appropriate dose, infusion rate, and treatment duration based on the patient’s clinical condition, renal function, and response to therapy. Specific dosing regimens are not provided here.

Safety data for levetiracetam during pregnancy and lactation are limited. The medication is classified as pregnancy category unknown. Clinicians must weigh potential benefits against possible risks to the fetus or infant, and discuss these considerations with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Levetiracetam offers a distinct mechanism by targeting SV2A, which differs from sodium‑channel blockers such as carbamazepine or GABA‑enhancers like valproate. It has a relatively low potential for drug‑enzyme interactions, a rapid onset when given intravenously, and a generally favorable tolerability profile compared with many older antiepileptics.

Levetiracetam Accord should be stored at room temperature, below 25 °C. Keep the solution in its original packaging, protect it from direct light, and avoid exposure to moisture. Do not freeze the product; inspect the container for any particulate matter before use.

Levetiracetam Accord is administered by intravenous infusion. The exact infusion rate and duration are determined by the prescribing physician, who may choose a rapid bolus or a slower infusion depending on the clinical scenario and patient tolerance.

Serious adverse events include severe allergic reactions such as anaphylaxis, psychiatric disturbances (including depression, suicidal ideation, or aggression), and hematologic abnormalities like thrombocytopenia or neutropenia. Prompt medical evaluation is required if any of these symptoms emerge during therapy.

Levetiracetam Accord is contraindicated in patients with known hypersensitivity to levetiracetam or any component of the formulation. Caution is advised for individuals with severe renal impairment, as dose adjustment may be required, and for patients with a history of serious psychiatric reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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