Product image of Levetiracetam Accord (Levetiracetam) supplied by GNH India

Levetiracetam Accord

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord, is an antiepileptic presented as an oral tablet for oral use. It is prescribed to control various seizure types in patients with epilepsy, reducing neuronal excitability and seizure frequency and improve quality of life. As part of a comprehensive treatment plan.

GNH India supplies Levetiracetam Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution, including temperature‑controlled shipping where required.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Levetiracetam is used in epilepsy management to reduce seizure activity across several seizure types.

  • Partial‑onset seizures: reduces seizure frequency and improves control in patients with focal epilepsy.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes and lowers risk of injury in generalized epilepsy.
  • Myoclonic seizures: decreases myoclonic jerks and improves daily functioning in patients with juvenile myoclonic epilepsy.
  • Adjunct therapy: can be combined with other antiepileptic drugs to enhance overall seizure control.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates calcium‑dependent exocytosis, stabilizing neuronal membranes and decreasing hyper‑synchronised firing. By reducing the release of excitatory neurotransmitters, the drug lowers neuronal excitability and interrupts the propagation of seizure activity throughout the central nervous system. The precise downstream pathways remain under investigation, but the net effect is a consistent antiepileptic action without significant affinity for traditional ion channels or receptors.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reactions (e.g., anaphylaxis, angioedema)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Suicidal thoughts or behavior

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure patient safety.

  • Renal function: adjust dose in patients with impaired renal clearance.
  • Pregnancy: risk category unknown; use only if benefits outweigh potential risks.
  • Psychiatric effects: monitor for mood changes, irritability, or depression.
  • Concomitant CNS depressants: may increase sedation when combined.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Levetiracetam can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may significantly reduce levetiracetam plasma concentrations.
  • Phenytoin: can lower levetiracetam levels, reducing seizure control.
  • Phenobarbital: may decrease levetiracetam exposure, compromising effectiveness.

Moderate Interactions (Monitor Closely)

  • Alcohol: combined use may enhance central nervous system depression.
  • Other antiepileptic drugs: may require dose adjustments based on therapeutic response.
  • Renal excretion inhibitors (e.g., probenecid): may increase levetiracetam levels, necessitating monitoring.

Frequently Asked Questions

Levetiracetam Accord is prescribed to treat epilepsy. It is indicated for partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures, helping to reduce the frequency and severity of seizure episodes in patients with these forms of epilepsy.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilises neuronal membranes, reduces excitatory neurotransmission, and lowers neuronal hyper‑excitability, thereby preventing the spread of seizure activity in the brain.

The appropriate dose of Levetiracetam Accord is determined by the prescribing clinician based on the patient’s age, weight, renal function, seizure type, and response to therapy. No fixed dosing regimen is provided here; the prescriber tailors the regimen to each individual.

Levetiracetam is classified with an unknown pregnancy category, meaning the risk cannot be definitively established. It should only be used during pregnancy or lactation if the potential benefits outweigh possible risks, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature‑controlled requirements) and the necessary import documentation.

Levetiracetam has a unique mechanism targeting SV2A, which differs from many traditional antiepileptics that act on sodium channels or GABA receptors. It is generally well tolerated, has few drug‑enzyme interactions, and can be used as monotherapy or adjunct therapy, offering an alternative when other agents are ineffective or poorly tolerated.

Levetiracetam Accord should be stored at room temperature, below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain product stability.

Levetiracetam Accord is taken orally, usually as a tablet. It may be swallowed whole with water and can be taken with or without food. The exact timing and frequency are determined by the prescribing physician based on the individual treatment plan.

Serious risks include severe allergic reactions such as anaphylaxis, rare skin conditions like Stevens‑Johnson syndrome or toxic epidermal necrolysis, and neuropsychiatric events such as suicidal thoughts or marked mood changes. Patients should be monitored closely for any of these signs and seek immediate medical attention if they occur.

Levetiracetam Accord should be avoided in patients with known hypersensitivity to levetiracetam or any of its excipients. Caution is also advised for individuals with severe renal impairment unless dose adjustments are made, and it is not recommended for use in pregnancy or breastfeeding without a clear medical justification.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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