Product image of Levetiracetam Accord (Levetiracetam) supplied by GNH India

Levetiracetam Accord

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord, is an antiepileptic presented as an oral tablet for oral use. It is prescribed to manage various seizure types in patients with epilepsy, including partial, generalized tonic‑clonic, and myoclonic seizures, and is approved for use in adults and children as determined by a healthcare professional.

GNH India supplies Levetiracetam Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Levetiracetam is an antiepileptic medication used to control seizures in the central nervous system.

  • Partial seizures: reduces the frequency of focal onset seizures, helping improve daily functioning and reduce the risk of seizure‑related injuries.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes, decreasing the likelihood of loss of consciousness and injury during seizures.
  • Myoclonic seizures: decreases sudden muscle jerks, contributing to better motor control and quality of life for patients with this seizure type.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A in neuronal membranes, modulating neurotransmitter release. This interaction stabilizes synaptic transmission and reduces excessive neuronal firing, thereby lowering the propensity for seizure activity. The precise downstream effects involve inhibition of calcium‑dependent exocytosis, contributing to its antiepileptic efficacy without significant interaction with traditional ion channels or receptors.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reactions (e.g., anaphylaxis, angioedema)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Mood alterations including depression, suicidal thoughts, or aggressive behavior

Precautions & Warnings

When prescribing levetiracetam, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust dose according to renal function and monitor levels.
  • Hepatic dysfunction: evaluate liver function tests before initiation.
  • Psychiatric symptoms: monitor patients for mood changes, depression, or suicidal ideation.
  • Pregnancy: risk category unknown; discuss potential benefits and risks with the patient.
  • Concomitant CNS depressants: may increase sedation; observe for enhanced central effects.
  • Store at ambient temperature: keep in original packaging, protect from moisture and heat.

Avoid Interactions

Levetiracetam can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may significantly reduce levetiracetam plasma concentrations.
  • Phenytoin: can decrease levetiracetam effectiveness.
  • Phenobarbital: may lower levetiracetam levels, compromising seizure control.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance central nervous system depression.
  • Other antiepileptic drugs: may require dose adjustments to maintain therapeutic effect.
  • Renal excretion inhibitors: monitor renal function and consider dosage modification.

Frequently Asked Questions

Levetiracetam Accord is used to treat epilepsy by reducing the frequency of partial, generalized tonic‑clonic, and myoclonic seizures. It is prescribed for patients who require seizure control as part of a comprehensive antiepileptic regimen.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilizes neuronal firing and diminishes excessive excitability, thereby lowering the likelihood of seizure activity without directly affecting ion channels.

The dose of Levetiracetam Accord is individualized. A qualified prescriber determines the appropriate amount based on the patient’s age, weight, renal function, seizure type, and response to therapy. No fixed dosing schedule is provided here.

Levetiracetam’s pregnancy category is not clearly defined, and data are limited. Healthcare providers should weigh potential benefits against uncertain risks. Breastfeeding mothers should consult their physician, as the drug can be excreted in breast milk.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older agents such as carbamazepine or valproate, levetiracetam has a relatively simple pharmacokinetic profile, fewer drug‑enzyme interactions, and is generally well tolerated. However, individual response varies, and clinicians choose therapy based on seizure type, comorbidities and patient tolerance.

Levetiracetam Accord should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, direct sunlight and excessive heat to maintain potency throughout its shelf life.

Levetiracetam Accord is taken orally, usually with water. It can be swallowed whole with or without food. Patients should follow the prescriber’s instructions regarding timing and whether the dose should be divided throughout the day.

Serious risks include severe allergic reactions such as anaphylaxis, skin conditions like Stevens‑Johnson syndrome, and significant mood changes that may lead to depression, suicidal thoughts, or aggressive behavior. Prompt medical attention is required if any of these occur.

Patients with known hypersensitivity to levetiracetam or any of its excipients should avoid the product. Caution is also advised for individuals with severe renal impairment, uncontrolled psychiatric disorders, or those taking medications that markedly reduce levetiracetam levels without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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