Product image of Levetiracetam Accord (Levetiracetam) supplied by GNH India

Levetiracetam Accord

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord, is an Anticonvulsant presented as an oral dosage form for oral use. It is employed to control partial, generalized tonic‑clonic and myoclonic seizures in patients diagnosed with epilepsy.

GNH India supplies Levetiracetam Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable delivery across global markets. Our manufacturing processes adhere to EU Good Manufacturing Practice (GMP) standards, ensuring product consistency and patient safety.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic drug that reduces seizure activity across several seizure types.
  • Partial seizures: reduces frequency and severity of focal onset seizures.
  • Generalized tonic‑clonic seizures: helps achieve seizure control in patients with primary generalized seizures.
  • Myoclonic seizures: diminishes rapid, brief muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates calcium‑dependent exocytosis, leading to decreased neuronal excitability and stabilization of hyper‑synchronous firing in the brain, thereby preventing the propagation of epileptic discharges. The precise downstream pathways remain under investigation, but the overall effect is a reduction in the likelihood of abnormal neuronal firing that underlies seizure generation.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness or imbalance.
  • Fatigue: unusual tiredness or lack of energy.
  • Headache: mild to moderate cranial pain.
  • Irritability: increased agitation or mood swings.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction with breathing difficulty, swelling, or rash.
  • Mood disorders: emergence of depression, anxiety, or suicidal ideation.
  • Stevens‑Johnson syndrome: rare, potentially life‑threatening skin eruption.

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure safe use.

  • Renal function: assess and adjust dose in patients with impaired renal clearance.
  • Psychiatric history: monitor for new or worsening depression or suicidal thoughts.
  • Concomitant CNS depressants: use caution as additive sedation may occur.
  • Pregnancy: evaluate risk‑benefit ratio; limited data available.
  • Elderly patients: start with lower dose and titrate slowly.
  • Store at ambient temperature: keep below 25 °C in original container, protect from moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma concentrations.
  • Phenobarbital: may decrease levetiracetam levels.
  • Phenytoin: potential reduction in levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Opioids (e.g., tramadol): increased risk of central nervous system depression.
  • Alcohol: may enhance dizziness and sedation.
  • Other antiepileptics (e.g., valproate): monitor for additive side effects.

Frequently Asked Questions

Levetiracetam Accord contains the active ingredient levetiracetam, an antiepileptic medication indicated for the treatment of partial (focal) seizures, generalized tonic‑clonic seizures and myoclonic seizures in patients with epilepsy. It helps reduce seizure frequency and severity when prescribed by a qualified healthcare professional.

Levetiracetam’s mechanism involves binding to the synaptic vesicle protein SV2A, which modulates neurotransmitter release and stabilizes neuronal firing. By decreasing calcium‑dependent exocytosis, the drug lowers neuronal excitability, thereby preventing the spread of abnormal electrical activity that can trigger seizures.

The appropriate dose of Levetiracetam Accord is determined individually by the prescribing clinician based on the patient’s age, weight, renal function and seizure type. Dosage adjustments are made according to clinical response and tolerability, and patients should follow the exact regimen provided by their healthcare provider.

Safety data for levetiracetam in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare professionals should discuss the risk‑benefit profile with the patient and consider alternative therapies when appropriate.

To request Levetiracetam Accord, visit the product page on gnhindia.com, enter the desired quantity and submit the inquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Compared with older antiepileptics such as carbamazepine or phenytoin, levetiracetam has a relatively favorable pharmacokinetic profile, minimal protein binding and fewer drug‑enzyme interactions. It is often chosen for its broad spectrum of activity across seizure types and its ease of dosing, though individual response varies.

Levetiracetam Accord should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Levetiracetam Accord is taken orally, usually with or without food, as directed by the prescribing clinician. The tablets are swallowed whole with a glass of water, and dosing intervals are maintained consistently to achieve stable blood concentrations.

The most serious adverse reactions to watch for include severe allergic responses such as anaphylaxis, mood disturbances like depression or suicidal thoughts, and rare but life‑threatening skin conditions such as Stevens‑Johnson syndrome. Patients experiencing any of these symptoms should seek immediate medical attention.

Levetiracetam is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is also advised for patients with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting medications that may significantly reduce its efficacy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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