Product image of Levetiracetam Accord (Levetiracetam) supplied by GNH India

Levetiracetam Accord

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord, is an anticonvulsant presented as an oral formulation for oral use. It treats partial, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy.

GNH India supplies Levetiracetam Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug used to control various seizure types.

  • Partial seizures: decreases frequency of focal onset seizures and may reduce associated aura symptoms.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes and lowers the risk of injury during seizures.
  • Myoclonic seizures: reduces rapid muscle jerks and improves overall seizure control in patients with juvenile myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates vesicle exocytosis, leading to decreased neuronal hyper‑excitability and stabilization of synaptic transmission. By limiting excessive glutamate release, the drug reduces the likelihood of seizure initiation without directly affecting ion channels or G‑protein coupled receptors. It does not significantly alter sodium or calcium channel activity, contributing to its favorable side‑effect profile.

Side Effects

Levetiracetam may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Fatigue: feeling unusually tired or lacking energy.
  • Headache: mild to moderate head pain.
  • Irritability: mood changes including increased agitation.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Stevens‑Johnson syndrome: serious skin eruption requiring immediate medical attention.
  • Suicidal thoughts: emergence of depressive symptoms or urges to self‑harm.

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several safety aspects to optimize therapy.

  • Renal function: adjust dose in patients with impaired renal clearance.
  • Pregnancy: category B; use only when benefit outweighs potential risk.
  • Concomitant CNS depressants: monitor for enhanced sedation or respiratory depression.
  • Behavioral changes: observe for mood swings, aggression, or depression.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its effectiveness or safety.

Major Interactions (Avoid)

  • Carbamazepine: enzyme induction may lower levetiracetam plasma concentrations.
  • Phenobarbital: strong enzyme inducer that can reduce therapeutic levels.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive CNS depression may increase drowsiness.
  • Other antiepileptics: combined use may require dose adjustments.
  • Oral contraceptives: levetiracetam may decrease hormonal efficacy, necessitating alternative contraception.

Frequently Asked Questions

Levetiracetam Accord is prescribed to manage epilepsy by reducing the frequency of partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It is used in adults and children who require an additional or alternative antiepileptic therapy to achieve better seizure control.

Levetiracetam binds to the synaptic vesicle protein SV2A, which plays a central role in neurotransmitter release. This binding modulates vesicle exocytosis, decreasing neuronal hyper‑excitability and stabilising synaptic transmission, thereby lowering the likelihood of seizure initiation without directly affecting ion channels.

The dose of Levetiracetam Accord is individualized by the prescribing clinician based on factors such as the patient’s age, weight, renal function, seizure type, and response to therapy. No fixed regimen is provided here; the prescriber will set the appropriate dosage and titration schedule.

Levetiracetam is classified as pregnancy category B, indicating that animal studies have not shown risk but there are limited human data. It may be used during pregnancy only when the potential benefit justifies any possible risk. Small amounts are excreted in breast milk, so breastfeeding decisions should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and assistance with import documentation.

Compared with many traditional antiepileptics, levetiracetam has a distinct mechanism (SV2A modulation) and a relatively low potential for drug‑enzyme interactions. It is often favoured for its simple dosing, minimal impact on hepatic metabolism, and a side‑effect profile that lacks significant sedation or cognitive impairment seen with some older agents.

Levetiracetam Accord should be stored at ambient temperature, below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains sealed until use to maintain stability.

Levetiracetam Accord is taken orally, usually as a tablet or oral solution, with or without food. The exact administration schedule—once daily, twice daily, or more—depends on the prescriber’s instructions and the individual patient’s therapeutic needs.

Serious adverse reactions, although rare, include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and the emergence of suicidal thoughts or depressive symptoms. Patients should be monitored for any skin rash, mood changes, or signs of hypersensitivity and seek immediate medical attention if these occur.

Levetiracetam Accord is contraindicated in patients with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for individuals with severe renal impairment who may require dose adjustment, and it should be avoided in patients where the risk of serious skin reactions or psychiatric side effects outweighs potential benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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