Product image of Levetiracetam Accord (Levetiracetam) supplied by GNH India

Levetiracetam Accord

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord, is an antiepileptic presented as an oral tablet for oral use. It is indicated for the treatment of partial, generalized tonic‑clonic and myoclonic seizures in patients diagnosed with epilepsy, helping to reduce seizure frequency.

GNH India supplies Levetiracetam Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets and ensuring quality compliance across EU and global jurisdictions.

Manufacturer / TM Owner

Accord Healthcare Polska Sp. Z O.O.

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Indications & Clinical Uses

Levetiracetam is used to manage epileptic seizure disorders by modulating neuronal excitability.

  • Partial seizures: reduces frequency of focal onset seizures in patients with epilepsy.
  • Generalized tonic-clonic seizures: controls bilateral convulsive seizures in epilepsy.
  • Myoclonic seizures: decreases occurrence of sudden muscle jerks in patients with myoclonic epilepsy.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a component involved in neurotransmitter release. This interaction modulates vesicular exocytosis, stabilizing synaptic transmission and decreasing neuronal hyperexcitability. By influencing the release of excitatory neurotransmitters, the drug helps to prevent the initiation and spread of seizure activity without directly affecting ion channels or G‑protein pathways.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness: sensation of lightheadedness or unsteadiness.
  • Fatigue: feeling unusually tired or weak.
  • Headache: mild to moderate cranial pain.
  • Irritability: increased emotional sensitivity or agitation.
  • Nausea: upset stomach with possible vomiting.
  • Somnolence: excessive sleepiness during the day.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Mood changes: depression, anxiety, or suicidal thoughts.
  • Behavioral disturbances: aggression or hostility.
  • Blood disorders: thrombocytopenia or leukopenia.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Stevens‑Johnson syndrome: severe skin blistering.

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust dose based on creatinine clearance.
  • Psychiatric history: monitor for mood swings, depression, or suicidal ideation.
  • Concomitant CNS depressants: observe for enhanced sedation.
  • Pregnancy: evaluate risk‑benefit, as safety data are limited.
  • Elderly patients: start with lower dose and monitor renal function.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels, decreasing effectiveness.
  • Phenobarbital: can lower levetiracetam concentrations, risking seizure breakthrough.

Moderate Interactions (Monitor Closely)

  • Valproic acid: may increase levetiracetam levels, requiring monitoring for toxicity.
  • Enzyme inducers (e.g., phenytoin, primidone): may modestly decrease levetiracetam exposure.
  • Oral contraceptives: levetiracetam may reduce hormonal efficacy, consider alternative contraception.
  • Alcohol: combined use can enhance CNS depression and dizziness.

Frequently Asked Questions

Levetiracetam Accord contains levetiracetam, an antiepileptic medication prescribed to control partial, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy. It helps reduce the frequency and severity of seizure episodes by stabilizing neuronal activity.

Levetiracetam binds to the synaptic vesicle protein SV2A, which plays a key role in neurotransmitter release. This binding modulates vesicle exocytosis, leading to reduced excitatory neurotransmission and decreased neuronal hyperexcitability, thereby lowering the likelihood of seizure generation.

The dosage of Levetiracetam Accord is individualized by the prescribing clinician based on the patient’s age, renal function, seizure type and response to therapy. Only a qualified healthcare professional should determine the appropriate dose and titration schedule.

Safety data for levetiracetam in pregnancy and lactation are limited. Clinicians must weigh the potential benefits for seizure control against any possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To request Levetiracetam Accord, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Levetiracetam differs from many traditional antiepileptics because it does not act on sodium channels or G‑protein pathways. Compared with drugs such as carbamazepine or valproic acid, it has a relatively favorable drug‑interaction profile and is generally well tolerated, though individual response and side‑effect patterns vary.

Levetiracetam Accord should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Levetiracetam Accord is taken orally as a tablet. Patients should swallow the tablet whole with water, preferably with or without food, as directed by their prescriber. Consistent dosing times help maintain stable blood levels.

Serious adverse events, although rare, include severe allergic reactions (rash, swelling, breathing difficulty), mood alterations such as depression or suicidal thoughts, behavioral disturbances, blood‑cell abnormalities, hepatic dysfunction and severe skin reactions like Stevens‑Johnson syndrome. Prompt medical attention is required if any of these occur.

Levetiracetam Accord is contraindicated in patients with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric conditions, or those taking interacting medications that may significantly alter levetiracetam levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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