Product image of Levetiracetam Accord (Levetiracetam) supplied by GNH India

Levetiracetam Accord

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord, is an anticonvulsant presented as an oral tablet for oral use. It treats various seizure types in patients with epilepsy.

GNH India supplies Levetiracetam Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Polska Sp. Z O.O.

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug used to control seizure activity across several epilepsy syndromes.

  • Partial seizures: reduces the frequency of focal onset seizures.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes.
  • Myoclonic seizures: decreases sudden muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilizing neuronal membranes. This interaction reduces abnormal neuronal firing and lowers overall excitability in the central nervous system, contributing to seizure control without directly affecting ion channels or GABA receptors.

Side Effects

Levetiracetam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dizziness: sensation of light‑headedness or imbalance.
  • Headache: mild to moderate cranial pain.
  • Irritability: mood changes or increased agitation.
  • Nausea: upset stomach or feeling of queasiness.
  • Nasal congestion: blocked or runny nose.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Mood disorders: depression, suicidal thoughts, or aggressive behavior.
  • Hematologic changes: low blood cell counts or abnormal clotting.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Patients should be aware of specific safety considerations when using Levetiracetam.

  • Pregnancy: Category B – use only if clearly needed after risk‑benefit assessment.
  • Renal function: dose may require adjustment in impaired kidney function.
  • Mood monitoring: watch for depression, anxiety, or suicidal ideation.
  • Concomitant CNS depressants: may enhance sedation or dizziness.
  • Driving and machinery: avoid until individual response is known.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenobarbital: may lower levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Alcohol: can increase central nervous system depression.
  • Other antiepileptics (e.g., valproate, lamotrigine): may require dose adjustments.
  • Oral contraceptives: limited data, monitor for reduced effectiveness.

Frequently Asked Questions

Levetiracetam Accord is prescribed to manage several types of epileptic seizures, including partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It helps reduce the frequency and severity of seizure episodes in patients diagnosed with epilepsy.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. By stabilizing synaptic transmission, it lowers neuronal excitability and prevents the rapid, uncontrolled firing that leads to seizures.

The specific dose of Levetiracetam Accord is determined by the prescribing clinician based on the patient’s age, weight, seizure type, and renal function. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Levetiracetam is classified as Pregnancy Category B, indicating no evidence of fetal risk in animal studies but limited human data. It may be used during pregnancy only if the potential benefit justifies the risk. Breastfeeding is generally considered compatible, but a healthcare professional should evaluate each case.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levetiracetam offers a distinct mechanism by targeting SV2A, which differs from sodium‑channel blockers like carbamazepine or GABA‑enhancers such as valproate. It generally has fewer drug‑enzyme interactions, a favorable tolerability profile, and can be used as adjunctive or monotherapy in many seizure types.

Store Levetiracetam Accord at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat and direct sunlight to maintain potency throughout the shelf life.

Levetiracetam Accord is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with water and not chewed or crushed unless specifically instructed.

Serious adverse reactions can include severe allergic responses (rash, swelling, breathing difficulty), mood disturbances such as depression or suicidal thoughts, and rare hematologic or hepatic abnormalities. Patients should seek immediate medical attention if any of these occur.

Levetiracetam Accord is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for patients with severe renal impairment, uncontrolled psychiatric conditions, or those taking interacting medications without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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