Product image of Levetiracetam Accord (Levetiracetam) supplied by GNH India

Levetiracetam Accord

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord, is an antiepileptic presented as an oral dosage form for oral use. It is employed to control various seizure types in patients with epilepsy and is approved for use in the European Union. Levetiracetam Accord is supplied in compliance with international quality standards and is intended for prescription‑only distribution.

GNH India supplies Levetiracetam Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug that reduces neuronal excitability in seizure disorders.

  • Partial‑onset seizures: decreases the frequency of focal seizures in patients with epilepsy.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes in generalized seizure disorders.
  • Myoclonic seizures: reduces myoclonic jerks in patients with juvenile myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilising neuronal membranes. This interaction reduces excessive neuronal firing and lowers the likelihood of seizure propagation without directly affecting ion channels or GABA receptors.

Side Effects

Levetiracetam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Fatigue: feeling unusually tired or weak.
  • Somnolence: increased sleepiness during the day.
  • Irritability: mood changes or agitation.
  • Headache: mild to moderate cranial pain.
  • Nausea: upset stomach or feeling of queasiness.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: rare skin blistering condition.
  • Suicidal thoughts or behavior: emergence of depressive symptoms.
  • Severe depression or mood disorders.
  • Blood dyscrasias: abnormal blood cell counts.
  • Life‑threatening rash: widespread skin eruptions.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Renal impairment: adjust dose based on creatinine clearance.
  • Hepatic dysfunction: monitor liver function tests periodically.
  • History of psychiatric disorders: observe for mood changes or suicidal ideation.
  • Pregnancy: discuss potential risks with the prescriber, as safety data are limited.
  • Concomitant CNS depressants: monitor for enhanced sedation or respiratory depression.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levetiracetam may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: may lower levetiracetam plasma concentrations.
  • Phenytoin: can reduce levetiracetam levels, compromising seizure control.
  • Phenobarbital: may decrease levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Alcohol: can potentiate central nervous system depression.
  • Valproate: monitor for additive effects on seizure control.
  • Probenecid: may increase levetiracetam levels, requiring dose review.

Frequently Asked Questions

Levetiracetam Accord is prescribed to treat partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients with epilepsy. It helps reduce the frequency and severity of seizure episodes by stabilising neuronal activity.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action dampens excessive neuronal firing, thereby decreasing the likelihood of seizure initiation and spread without directly influencing ion channels.

The appropriate dose of Levetiracetam Accord is determined by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. Dosage adjustments are made to achieve optimal seizure control while minimising side effects.

Safety data for levetiracetam in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and discuss these considerations with the patient. Breastfeeding decisions should also be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levetiracetam offers a favourable safety profile and minimal drug‑enzyme interactions compared with many older antiepileptics such as carbamazepine or phenytoin. Its unique SV2A binding mechanism provides effective seizure control, though individual response varies and choice of therapy should be personalised.

Levetiracetam Accord should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain potency throughout its shelf life.

Levetiracetam Accord is taken orally, usually with or without food, as directed by the prescriber. The tablet should be swallowed whole with water and not chewed or crushed unless specifically advised.

Serious risks include severe allergic reactions, Stevens‑Johnson syndrome, suicidal thoughts or behaviours, and significant mood changes such as depression. Patients should seek immediate medical attention if they notice rash, swelling, mood alterations, or thoughts of self‑harm.

Patients with known hypersensitivity to levetiracetam or any of its excipients should avoid the product. Caution is also advised for individuals with severe renal impairment, uncontrolled psychiatric conditions, or those taking interacting medications without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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