Product image of Levetiracetam Accord Healthcare (Levetiracetam) supplied by GNH India

Levetiracetam Accord Healthcare

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Accord Healthcare (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Accord Healthcare, is an antiepileptic presented as an oral tablet for oral use. It is indicated for the treatment of partial seizures, generalized tonic‑clonic seizures and myoclonic seizures in patients diagnosed with epilepsy. The medication works by modulating neuronal excitability through binding to synaptic vesicle protein SV2A, which helps to stabilize abnormal electrical activity in the brain.

GNH India supplies Levetiracetam Accord Healthcare as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

  • Levetiracetam is used in epilepsy management to control various seizure types.
  • Partial seizures: Decreases the number of focal onset seizures and may lessen associated neurological symptoms, improving daily functioning.
  • Generalized tonic‑clonic seizures: Lowers the incidence of bilateral convulsive seizures, contributing to better seizure control in generalized epilepsy.
  • Myoclonic seizures: Reduces the frequency of sudden, brief muscle jerks, aiding patients with juvenile myoclonic epilepsy.
  • Adjunct therapy: Can be combined with other antiepileptic drugs when monotherapy is insufficient.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic vesicle exocytosis, leading to reduced neuronal hyper‑excitability and stabilization of abnormal electrical firing in the central nervous system. The precise downstream effects are not fully understood, but the SV2A binding results in an overall anticonvulsant effect without significant interaction with ion channels or G‑protein‑coupled receptors.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reactions (e.g., Stevens‑Johnson syndrome)
  • Mood changes including depression or suicidal thoughts
  • Hematologic abnormalities such as neutropenia

Precautions & Warnings

When prescribing levetiracetam, consider the following precautions.

  • Renal impairment: Adjust dose in patients with reduced kidney function.
  • Psychiatric symptoms: Monitor for depression, anxiety, or behavioral changes.
  • Concomitant CNS depressants: Use caution as additive sedation may occur.
  • Pregnancy: Limited data; weigh potential benefits against risks.
  • Store at ambient temperature: Keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Levetiracetam can interact with several medicines; review patient medication lists carefully.

Major Interactions (Avoid)

  • Carbamazepine: May reduce levetiracetam plasma levels.
  • Phenobarbital: May decrease efficacy of levetiracetam.

Moderate Interactions (Monitor Closely)

  • Alcohol: Can enhance central nervous system depression.
  • Other antiepileptic drugs: May require dose adjustments.

Frequently Asked Questions

Levetiracetam Accord Healthcare is prescribed to treat partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients with epilepsy. It helps reduce the frequency and severity of these seizure types.

Levetiracetam binds to the synaptic vesicle protein SV2A, which regulates neurotransmitter release. This binding modulates vesicle exocytosis, decreasing neuronal hyper‑excitability and stabilising abnormal electrical activity in the brain, thereby providing an anticonvulsant effect.

The specific dose of Levetiracetam Accord Healthcare is determined by the prescribing clinician based on the patient’s age, weight, renal function, seizure type and response to therapy. No fixed regimen is provided here.

Safety data for levetiracetam in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative therapies when appropriate. Breastfeeding decisions should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levetiracetam has a unique mechanism involving SV2A binding, which differs from many older antiepileptics that target ion channels or G‑protein pathways. It is generally well tolerated, has minimal drug‑enzyme interactions, and is often used when other agents are ineffective or cause intolerable side effects.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the packaging remains sealed until use.

Levetiracetam Accord Healthcare is taken orally, usually as a tablet. It can be swallowed whole with water and may be taken with or without food, as directed by the prescribing clinician.

Serious risks include severe allergic reactions such as Stevens‑Johnson syndrome, significant mood changes including depression or suicidal thoughts, and rare hematologic abnormalities like neutropenia. Patients should be monitored closely for these events.

Patients with known hypersensitivity to levetiracetam or any of its excipients should avoid the product. Caution is advised in individuals with severe renal impairment, uncontrolled psychiatric conditions, or those taking interacting medications listed under major interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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