Product image of Levetiracetam Actavis (Levetiracetam) supplied by GNH India

Levetiracetam Actavis

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Actavis (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Actavis, is an anticonvulsant presented as an oral tablet for oral use. It is prescribed to manage various seizure types in patients with epilepsy. The medication works by modulating neuronal activity, helping to control abnormal electrical discharges in the brain.

GNH India supplies Levetiracetam Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our global distribution network ensures reliable access to quality‑assured medicines across diverse markets while adhering to stringent regulatory standards to maintain product integrity.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

  • Levetiracetam is used to treat epilepsy by targeting seizure activity across several seizure categories.
  • Partial‑onset seizures: reduces seizure frequency in patients with focal epilepsy.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes in generalized epilepsy.
  • Myoclonic seizures: decreases myoclonic jerks in patients with juvenile myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic transmission, stabilizing neuronal firing and lowering the likelihood of hyper‑excitable bursts that precipitate seizures. The precise downstream effects involve reduced calcium‑dependent exocytosis, contributing to its antiepileptic activity.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Headache: mild to moderate cranial pain.
  • Irritability: mood changes or increased agitation.
  • Nausea: upset stomach with possible vomiting.
  • Weight gain: increase in body weight over time.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Psychiatric symptoms: depression, suicidal thoughts, or severe anxiety.
  • Blood disorders: low platelet count or neutropenia.
  • Skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Liver injury: jaundice or elevated liver enzymes.

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure safe use.

  • Renal function: adjust dose in patients with impaired kidney function.
  • Pregnancy: evaluate risk‑benefit as safety data are limited.
  • Psychiatric history: monitor for mood changes or suicidal ideation.
  • Concomitant CNS depressants: use caution as additive sedation may occur.
  • Alcohol use: advise patients to limit intake due to potential increased drowsiness.
  • Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels, decreasing effectiveness.
  • Phenobarbital: can lower levetiracetam concentrations, risking breakthrough seizures.
  • Phenytoin: may decrease levetiracetam exposure, requiring close monitoring.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance central nervous system depression, increasing drowsiness.
  • Other antiepileptics (e.g., valproate): may require dose adjustments based on therapeutic monitoring.
  • Contraceptive steroids: potential reduction in hormonal efficacy, advise alternative contraception.

Frequently Asked Questions

Levetiracetam Actavis is an antiepileptic medication indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It helps reduce the frequency and severity of seizure episodes in patients diagnosed with epilepsy.

Levetiracetam exerts its effect by binding to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilizes neuronal firing and diminishes the hyper‑excitability that leads to seizure activity, providing broad seizure control across several epilepsy syndromes.

The appropriate dose of Levetiracetam is individualized by the prescribing healthcare professional based on the patient’s age, weight, renal function, and seizure type. Dosage regimens may vary, and any adjustments should be made under medical supervision.

Safety data for Levetiracetam in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and discuss them with the patient. If treatment is necessary, close monitoring is recommended, and alternative therapies may be considered.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Levetiracetam offers a favorable pharmacokinetic profile with minimal protein binding and few drug‑enzyme interactions, distinguishing it from many older antiepileptics such as carbamazepine or phenytoin. It is often chosen for its broad spectrum of activity and relatively predictable dosing, though individual response varies.

Levetiracetam tablets should be stored at ambient temperature, below 25 °C, in the original container to protect from moisture and light. Keep the product out of reach of children and avoid exposure to extreme temperatures or humidity.

Levetiracetam is taken orally, usually as a tablet, with or without food. The exact administration schedule—once, twice, or three times daily—depends on the prescriber’s instructions and the patient’s therapeutic needs.

Serious adverse events include severe allergic reactions, psychiatric disturbances such as depression or suicidal thoughts, blood dyscrasias, and rare skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience rash, mood changes, or signs of infection.

Levetiracetam is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Caution is also advised for patients with severe renal impairment, uncontrolled psychiatric illness, or those taking interacting medications that may diminish its efficacy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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