Product image of Levetiracetam Al (Levetiracetam) supplied by GNH India

Levetiracetam Al

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Al (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Al, is an anticonvulsant presented as an oral tablet for oral use. It is indicated for the treatment of partial seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients diagnosed with epilepsy.

GNH India supplies Levetiracetam Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution channels that meet EU regulatory standards. The company ensures product integrity through rigorous quality control and provides logistical support for global procurement.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

Levetiracetam is an antiepileptic medication used to control seizure activity across several seizure types.

  • Partial seizures: reduces frequency and severity of focal onset seizures.
  • Generalized tonic-clonic seizures: helps prevent convulsive episodes in patients with generalized epilepsy.
  • Myoclonic seizures: decreases sudden muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates calcium‑dependent exocytosis, stabilizing neuronal membranes and reducing hyper‑excitability. By decreasing synchronized neuronal firing, the drug lowers the likelihood of seizure propagation without directly affecting ion channels or GABA receptors. The precise downstream effects remain under investigation, but the overall result is a dampening of abnormal electrical activity in the central nervous system.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Somnolence: increased sleepiness or fatigue.
  • Headache: mild to moderate cranial pain.
  • Irritability: mood changes or agitation.
  • Nausea: gastrointestinal discomfort.
  • Fatigue: reduced energy levels.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Stevens‑Johnson syndrome: severe skin blistering and mucosal involvement.
  • Suicidal thoughts: emergence of depressive ideation or self‑harm urges.
  • Severe depression: marked mood decline requiring urgent evaluation.
  • Blood disorders: thrombocytopenia or leukopenia.
  • Rash: widespread or persistent cutaneous eruption.

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure patient safety.

  • Renal impairment: dose may need adjustment in patients with reduced kidney function.
  • Hepatic dysfunction: monitor liver enzymes during therapy.
  • Psychiatric symptoms: watch for mood changes, irritability, or depression.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Concomitant CNS depressants: may enhance sedation.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its effectiveness or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Enzyme‑inducing antiepileptics (phenytoin, phenobarbital): may decrease efficacy.
  • Strong CYP3A4 inhibitors (ketoconazole): may increase levetiracetam concentrations.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs): possible increased irritability.
  • Alcohol: additive central nervous system depression.
  • Oral contraceptives: may slightly reduce hormonal efficacy.

Frequently Asked Questions

Levetiracetam Al is prescribed for the management of epilepsy, specifically to control partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It helps reduce the frequency and severity of seizure episodes in patients diagnosed with these seizure types.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilizes neuronal membranes, reduces abnormal calcium‑dependent exocytosis, and lowers neuronal hyper‑excitability, thereby decreasing the likelihood of seizure propagation.

The appropriate dose of Levetiracetam Al is determined by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for levetiracetam in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To request Levetiracetam Al, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levetiracetam differs from many traditional antiepileptics because it does not act directly on ion channels or GABA receptors. Its unique SV2A binding often results in a favorable side‑effect profile and fewer drug‑drug interactions, making it a common alternative to agents such as carbamazepine or valproate for certain seizure types.

Levetiracetam Al should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat, and direct sunlight to maintain product stability.

Levetiracetam Al is taken orally, usually as a tablet. It can be swallowed whole with water and may be taken with or without food, according to the prescriber’s guidance.

Serious risks, though uncommon, include severe allergic reactions, Stevens‑Johnson syndrome, suicidal thoughts or behaviors, marked depression, and hematologic abnormalities such as thrombocytopenia. Patients should seek immediate medical attention if they experience any of these symptoms.

Levetiracetam Al is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for patients with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting medications that may significantly alter its plasma levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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