Product image of Levetiracetam Aurobindo (Levetiracetam) supplied by GNH India

Levetiracetam Aurobindo

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Aurobindo (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Aurobindo, is an antiepileptic presented as an oral tablet for oral use and marketed in the European Union. It is indicated for the treatment of partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients diagnosed with epilepsy, helping to reduce seizure frequency and improve neurological stability.

GNH India supplies Levetiracetam Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with capabilities for bulk manufacturing, quality assurance and regulatory support to meet global market demands.

Manufacturer / TM Owner

Aurobindo Pharma (Malta) Limited

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug that reduces neuronal hyper‑excitability in various seizure types.

  • Partial‑onset seizures: reduces frequency of focal seizures and improves seizure control.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes in patients with generalized epilepsy.
  • Myoclonic seizures: decreases rapid muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilizing neuronal firing. This interaction is thought to inhibit excessive synaptic transmission, thereby reducing neuronal hyper‑excitability and seizure activity. The drug does not significantly interact with voltage‑gated sodium channels, calcium channels, or GABA‑ergic mechanisms, which contributes to its favorable pharmacokinetic profile and low potential for drug‑drug interactions.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Somnolence
  • Irritability

Serious or Rare Side Effects

  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Depression or suicidal thoughts
  • Blood dyscrasias (e.g., neutropenia, thrombocytopenia)
  • Hepatic dysfunction

Precautions & Warnings

When prescribing levetiracetam, clinicians should consider several safety aspects.

  • Renal impairment: assess kidney function and adjust dose if necessary.
  • Hepatic impairment: monitor liver enzymes periodically.
  • Psychiatric symptoms: observe for mood changes, depression, or suicidal ideation.
  • Pregnancy: risk category unknown; discuss potential benefits and risks with the patient.
  • Concomitant CNS depressants: use caution as additive sedation may occur.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its plasma levels or enhancing central nervous system effects.

Major Interactions (Avoid)

  • Carbamazepine: may significantly reduce levetiracetam concentrations.
  • Phenytoin: may lower levetiracetam exposure.
  • Phenobarbital: can decrease levetiracetam levels.

Moderate Interactions (Monitor Closely)

  • Benzodiazepines: may increase sedation when combined.
  • Alcohol: can enhance central nervous system depression.
  • Antidepressants: monitor for worsening mood or suicidal thoughts.

Frequently Asked Questions

Levetiracetam Aurobindo is a generic antiepileptic medication indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients with epilepsy. By reducing abnormal neuronal firing, it helps control seizure frequency and improve overall neurological stability. The product is supplied in oral tablet form for systemic administration.

Levetiracetam exerts its effect by binding to the synaptic vesicle protein SV2A, which modulates neurotransmitter release at the presynaptic terminal. This binding stabilizes neuronal firing and diminishes excessive synaptic transmission, thereby lowering neuronal hyper‑excitability that leads to seizures. The mechanism is distinct from traditional sodium‑channel blockers or GABA‑enhancing agents.

The appropriate dose of levetiracetam is individualized and must be determined by a qualified prescriber based on the patient’s age, weight, renal function, and seizure type. Dosage adjustments are often required for patients with impaired kidney function. Patients should follow the prescribing information and never alter the dose without medical guidance.

The safety of levetiracetam in pregnancy and lactation has not been definitively established, and it is classified as a pregnancy category with unknown risk. Healthcare providers weigh the potential benefits of seizure control against possible fetal exposure. Breastfeeding mothers should discuss risks with their physician, as the drug can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any temperature requirements) and assists with import documentation.

Compared with many traditional antiepileptics, levetiracetam has a relatively simple pharmacokinetic profile, minimal protein binding, and few drug‑drug interactions. It does not act on sodium channels or GABA receptors, which can reduce certain side‑effects. However, it may cause behavioral changes in some patients. Clinicians often choose levetiracetam for its broad spectrum of activity and ease of dosing, especially when polytherapy is required.

Levetiracetam tablets should be stored at room temperature, typically below 25 °C, in the original blister pack or container to protect them from moisture and light. Do not store in areas with high humidity or extreme temperatures, and keep out of reach of children. Proper storage helps maintain product potency throughout its shelf life.

Levetiracetam is administered orally, usually as whole tablets swallowed with water. It can be taken with or without food, and the dosing schedule

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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