Product image of Levetiracetam Biogaran (Levetiracetam) supplied by GNH India

Levetiracetam Biogaran

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Biogaran (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Biogaran, is an antiepileptic presented as an oral tablet for oral use. It is used to control partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy and to reduce seizure frequency and severity.

GNH India supplies Levetiracetam Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Our network includes regulatory support and after‑sales service to ensure continuous patient access.

Manufacturer / TM Owner

Biogaran

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic that modulates neuronal excitability to treat several seizure types.
  • Partial‑onset seizures: reduces frequency of focal seizures.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes.
  • Myoclonic seizures: diminishes rapid muscle jerks associated with epilepsy.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates calcium‑dependent exocytosis, stabilizing synaptic transmission and decreasing abnormal neuronal firing. By reducing the release of excitatory neurotransmitters, the drug lowers neuronal hyperexcitability that underlies various seizure disorders. The precise binding site remains under investigation, but the overall effect is a net inhibition of excessive synaptic activity without significant interaction with GABA or glutamate receptors.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness or imbalance.
  • Fatigue: unusual tiredness or lack of energy.
  • Headache: mild to moderate cranial pain.
  • Nausea: feeling of stomach upset or urge to vomit.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Psychiatric changes: depression, anxiety, or suicidal thoughts.
  • Blood disorders: thrombocytopenia or leukopenia.

Precautions & Warnings

  • Before prescribing Levetiracetam, clinicians should consider several safety considerations.
  • Renal impairment: adjust dose based on creatinine clearance.
  • Hepatic dysfunction: monitor liver enzymes regularly.
  • Psychiatric history: observe for mood changes or suicidal ideation.
  • Concomitant CNS depressants: assess additive sedation risk.
  • Pregnancy: use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its effectiveness or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels, decreasing efficacy.
  • Phenobarbital: enzyme induction can lower levetiracetam concentrations.

Moderate Interactions (Monitor Closely)

  • Alcohol: combined CNS depression may increase dizziness and sedation.
  • Other antiepileptics (e.g., valproate): monitor seizure control and plasma levels.
  • Antidepressants (e.g., SSRIs): watch for increased behavioral changes.

Frequently Asked Questions

Levetiracetam Biogaran is an antiepileptic medication indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients diagnosed with epilepsy. It helps to reduce the frequency and severity of seizure episodes by stabilizing neuronal activity.

Levetiracetam works by binding to the synaptic vesicle protein SV2A, which plays a crucial role in the regulation of neurotransmitter release. This binding modulates calcium‑dependent exocytosis, leading to a reduction in the release of excitatory neurotransmitters and thereby decreasing neuronal hyperexcitability that triggers seizures.

The dosage of Levetiracetam Biogaran is individualized and must be determined by a qualified prescriber based on the patient’s age, weight, renal function, and seizure type. Physicians typically start with a low dose and titrate upward to achieve optimal seizure control while monitoring tolerability.

Levetiracetam is classified as pregnancy category unknown, meaning its safety has not been fully established. It should only be used during pregnancy or lactation if the potential benefit outweighs the possible risk. Patients should discuss their specific situation with a healthcare professional before continuing therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Levetiracetam Biogaran. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levetiracetam offers a distinct mechanism of action by targeting SV2A, which differs from sodium‑channel blockers like carbamazepine or GABA‑enhancers such as valproate. It generally has fewer drug‑enzyme interactions, a favorable pharmacokinetic profile, and is often chosen when patients experience side effects or inadequate control with other agents.

Levetiracetam Biogaran tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Protect the product from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout its shelf life.

The medication is supplied as oral tablets and should be swallowed whole with a glass of water. It can be taken with or without food, but consistency with regard to meals helps maintain steady plasma concentrations.

Serious adverse events, although rare, include severe allergic reactions (rash, swelling, breathing difficulty), significant psychiatric changes such as depression, anxiety or suicidal thoughts, and hematologic abnormalities like thrombocytopenia or leukopenia. Immediate medical attention is required if any of these symptoms appear.

Patients with a known hypersensitivity to levetiracetam or any component of the tablet should avoid its use. Caution is also advised for individuals with severe renal impairment, as dose adjustment may be required, and for those with a history of serious psychiatric disorders until evaluated by a clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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