Product image of Levetiracetam Brown & Burk (Levetiracetam) supplied by GNH India

Levetiracetam Brown & Burk

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Brown & Burk (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Brown & Burk, is an anticonvulsant presented as an oral tablet for oral use. It is indicated for the treatment of partial, generalized tonic‑clonic, and myoclonic seizures in patients with epilepsy.

GNH India supplies Levetiracetam Brown & Burk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across EU and global markets. The product meets European pharmacopoeia standards and is manufactured under GMP conditions. It is distributed through a secure logistics network that maintains product integrity during transport.

Manufacturer / TM Owner

Brown & Burk Uk Limited

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Indications & Clinical Uses

Levetiracetam is an anticonvulsant used to control seizure activity in various epilepsy syndromes.

  • Partial seizures: Reduces frequency of focal onset seizures, improving seizure control.
  • Generalized tonic‑clonic seizures: Decreases occurrence of bilateral convulsive seizures in patients with generalized epilepsy.
  • Myoclonic seizures: Helps prevent sudden muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release. This interaction stabilizes neuronal membranes and reduces hyper‑excitability, thereby diminishing the propagation of epileptic discharges. The precise downstream effects involve alteration of calcium‑dependent exocytosis, which contributes to its antiepileptic activity without significant interaction with G‑protein‑coupled receptors or ion channels.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Nausea
  • Irritability
  • Somnolence

Serious or Rare Side Effects

  • Severe allergic reactions (e.g., Stevens‑Johnson syndrome)
  • Mood changes including depression or suicidal thoughts
  • Hematologic abnormalities such as leukopenia
  • Rash with systemic involvement
  • Multifocal seizure worsening (rare)

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: Adjust dose based on creatinine clearance.
  • History of psychiatric disorders: Monitor for mood changes or depression.
  • Concomitant CNS depressants: Observe for additive sedation.
  • Pregnancy: Use only if potential benefit justifies potential risk; data are limited.
  • Elderly patients: Start at lower dose and titrate cautiously.
  • Store at ambient temperature: Keep below 25 °C, protect from moisture and light in original packaging.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: May reduce levetiracetam plasma levels, decreasing effectiveness.
  • Phenobarbital: Can lower levetiracetam concentrations, requiring close monitoring.

Moderate Interactions (Monitor Closely)

  • Alcohol: May enhance central nervous system depression.
  • Other antiepileptic drugs (e.g., valproate, phenytoin): May require dose adjustments.
  • Oral contraceptives: Potentially reduced hormonal efficacy, advise alternative contraception.

Frequently Asked Questions

Levetiracetam Brown & Burk is a generic anticonvulsant indicated for the treatment of partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients diagnosed with epilepsy. It helps reduce the frequency and severity of seizure episodes across these seizure types.

Levetiracetam exerts its antiepileptic effect by binding to the synaptic vesicle protein SV2A. This binding modulates neurotransmitter release, stabilizes neuronal firing, and diminishes hyper‑excitability in the brain, thereby lowering the likelihood of seizure propagation.

The dose of Levetiracetam Brown & Burk is individualized. A qualified prescriber determines the appropriate starting dose, titration schedule, and maintenance dose based on the patient’s age, renal function, seizure type, and clinical response. No fixed regimen is provided here.

Safety data for levetiracetam in pregnancy are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit outweighs any possible risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as the drug is excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details, and any necessary import documentation.

Compared with older agents such as carbamazepine or valproate, levetiracetam has a distinct mechanism (SV2A binding) and generally fewer drug‑enzyme interactions, which simplifies combination therapy. It is often well‑tolerated, but clinicians still assess individual efficacy, side‑effect profile, and patient comorbidities when selecting therapy.

Store the tablets at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct light, and ensure the packaging remains sealed until use. No refrigeration is required.

Levetiracetam Brown & Burk is taken orally. Tablets should be swallowed whole with a glass of water and may be taken with or without food, according to the prescriber’s instructions. Consistent timing helps maintain stable blood levels.

Serious adverse reactions include severe allergic responses such as Stevens‑Johnson syndrome, marked mood alterations (including depression or suicidal ideation), and rare hematologic abnormalities like leukopenia. Patients should be monitored closely for any new or worsening psychiatric symptoms or skin reactions.

Levetiracetam is contraindicated in patients with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting medications that significantly lower its plasma concentration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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