Product image of Levetiracetam Clonmel (Levetiracetam) supplied by GNH India

Levetiracetam Clonmel

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Clonmel (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Clonmel, is an anticonvulsant presented as an oral tablet for oral use. It is employed to control partial, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy. It is approved for use in adults and children as part of a comprehensive epilepsy management plan.

GNH India supplies Levetiracetam Clonmel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across EU and global markets.

Manufacturer / TM Owner

Clonmel Healthcare Ltd.

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Indications & Clinical Uses

  • Levetiracetam is an anticonvulsant indicated for several seizure types within the epilepsy disease spectrum.
  • Partial seizures: reduces frequency and severity of focal onset seizures.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes in patients with generalized epilepsy.
  • Myoclonic seizures: decreases sudden muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A in neuronal terminals. This interaction modulates neurotransmitter release, stabilising synaptic transmission and reducing neuronal hyper‑excitability. By influencing calcium‑dependent exocytosis, the drug diminishes the propagation of abnormal electrical activity that underlies seizure generation, providing broad‑spectrum antiepileptic activity without significant interaction with classic ion‑channel targets.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dizziness: light‑headed sensation, especially when standing quickly.
  • Headache: mild to moderate cranial pain.
  • Irritability or mood changes: increased agitation or emotional lability.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing requiring immediate medical attention.
  • Psychiatric disturbances: new or worsening depression, suicidal thoughts, or psychosis.
  • Blood disorders: rare cases of neutropenia or thrombocytopenia.

Precautions & Warnings

  • When prescribing Levetiracetam, clinicians should consider several safety and handling measures.
  • Renal impairment: adjust dose in patients with reduced kidney function.
  • Pregnancy: category B1, use only if benefit outweighs risk.
  • Behavioral changes: monitor for mood swings, aggression, or depression.
  • Concomitant CNS depressants: use caution as additive sedation may occur.
  • Drug discontinuation: taper gradually to avoid seizure exacerbation.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: strong enzyme inducer that may lower levetiracetam plasma levels.
  • Phenobarbital: may reduce levetiracetam exposure, potentially decreasing seizure control.

Moderate Interactions (Monitor Closely)

  • Acetazolamide: may increase levetiracetam concentrations, requiring monitoring.
  • Topiramate: additive CNS effects such as dizziness or fatigue.
  • Alcohol: enhances sedative effects, advise limited intake.

Frequently Asked Questions

Levetiracetam Clonmel is used to treat epilepsy by reducing the frequency of partial, generalized tonic‑clonic and myoclonic seizures. It is prescribed as part of a comprehensive seizure‑management plan for patients of various ages who require an oral antiepileptic medication.

Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This binding modulates calcium‑dependent exocytosis, stabilising neuronal firing and lowering the likelihood of the abnormal electrical discharges that cause seizures.

The appropriate dose is individualized by the prescribing clinician based on factors such as the patient’s age, weight, renal function, seizure type and response to therapy. No fixed regimen is provided here; dosing decisions are made by a qualified healthcare professional.

Levetiracetam is classified as pregnancy category B1, indicating no evidence of fetal risk in animal studies but limited human data. It may be used during pregnancy only when the potential benefit justifies the risk. Limited data suggest it is excreted in breast milk; breastfeeding decisions should be made with a physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Levetiracetam offers a broad‑spectrum effect with minimal enzyme‑inducing properties, reducing the likelihood of drug‑drug interactions compared with many older antiepileptics such as carbamazepine or phenytoin. Its rapid absorption and linear pharmacokinetics make dosing predictable, though clinicians may still consider individual patient factors when selecting therapy.

Store Levetiracetam tablets at ambient temperature, preferably below 25 °C, in the original container to protect from moisture and light. Keep out of reach of children and avoid exposing the product to excessive heat or humidity.

Levetiracetam is taken orally, usually as a tablet swallowed whole with water. It can be taken with or without food. The exact timing and frequency are determined by the prescriber to maintain consistent blood levels and optimal seizure control.

Serious risks include severe allergic reactions (rash, swelling, breathing difficulty), psychiatric disturbances such as new‑onset depression, suicidal thoughts or psychosis, and rare blood disorders like neutropenia. Patients should seek immediate medical attention if any of these symptoms occur.

Levetiracetam is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for patients with severe renal impairment, uncontrolled psychiatric illness, or those who cannot safely taper off the medication under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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