Product image of Levetiracetam Desitin (Levetiracetam) supplied by GNH India

Levetiracetam Desitin

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Desitin (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Desitin, is an anticonvulsant presented as an intravenous solution for intravenous use. It is used to control partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy.

GNH India supplies Levetiracetam Desitin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Desitin Arzneimittel Gmbh

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug that modulates neuronal excitability in various seizure types.

  • Partial‑onset seizures: reduces seizure frequency in patients with focal epilepsy.
  • Generalized tonic‑clonic seizures: helps achieve seizure control in patients with primary generalized epilepsy.
  • Myoclonic seizures: diminishes myoclonic jerks and improves overall seizure management.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic vesicle exocytosis, leading to decreased neuronal hyper‑excitability and reduced propagation of seizure activity across neuronal networks.

Side Effects

Levetiracetam may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Fatigue: feeling unusually tired or weak.
  • Somnolence: increased sleepiness during the day.
  • Headache: mild to moderate cranial pain.
  • Irritability: mood changes or increased agitation.
  • Nausea: upset stomach or feeling of queasiness.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: serious skin disorder with blistering.
  • Blood dyscrasias: abnormal blood counts such as neutropenia.
  • Suicidal thoughts or behavior: emergence of depressive symptoms.
  • Severe depression: marked mood disturbances requiring medical attention.

Precautions & Warnings

Levetiracetam requires careful monitoring in specific clinical situations.

  • Renal impairment: monitor renal function and consider dose adjustment.
  • Hepatic impairment: use with caution and observe for altered metabolism.
  • Pregnancy: risk unknown; weigh benefits against potential fetal exposure.
  • Concomitant CNS depressants: monitor for additive sedation or respiratory depression.
  • Psychiatric symptoms: observe for mood changes, aggression, or suicidal ideation.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levetiracetam has a relatively low interaction profile, but certain agents can affect its plasma levels.

Major Interactions (Avoid)

  • Strong enzyme inducers (e.g., carbamazepine, phenytoin, phenobarbital): may significantly lower levetiracetam concentrations, reducing efficacy.
  • Live vaccines: concurrent use may increase risk of vaccine‑related adverse events.

Moderate Interactions (Monitor Closely)

  • Alcohol: can enhance central nervous system depression and increase somnolence.
  • Other antiepileptic drugs (e.g., valproate): may require therapeutic drug monitoring.
  • Sedating antihistamines or opioids: monitor for additive sedation and respiratory effects.

Frequently Asked Questions

Levetiracetam Desitin is an intravenous antiepileptic medication indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients with epilepsy. It helps reduce the frequency and severity of seizure episodes by stabilizing neuronal activity.

Levetiracetam binds to the synaptic vesicle protein SV2A, which plays a crucial role in neurotransmitter release. This binding modulates vesicle exocytosis, leading to decreased neuronal excitability and suppression of abnormal electrical activity that triggers seizures.

The dosage of levetiracetam is individualized by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. The prescriber determines the appropriate infusion rate and total daily amount according to clinical guidelines and patient response.

Safety data for levetiracetam in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss risks and alternatives with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Levetiracetam is distinguished by its unique SV2A binding mechanism, minimal hepatic metabolism, and a relatively low potential for drug‑drug interactions compared with many older antiepileptics. This profile often makes it a preferred option when polypharmacy or hepatic impairment is a concern.

Levetiracetam Desitin should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Do not freeze the product, and ensure the vial is kept upright to avoid agitation of the solution.

Levetiracetam Desitin is administered intravenously by a healthcare professional. The solution is typically diluted in a compatible IV fluid and infused over a period determined by the prescriber, ensuring aseptic technique and proper monitoring during administration.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, blood dyscrasias, and the emergence of suicidal thoughts or severe depression. Patients should be monitored closely for any signs of these conditions, and immediate medical attention is required if they occur.

Levetiracetam is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is also advised for patients with severe renal impairment, uncontrolled psychiatric disorders, or those taking medications that may significantly reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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