Product image of Levetiracetam G.L. (Levetiracetam) supplied by GNH India

Levetiracetam G.L.

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam G.L. (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam G.L., is an antiepileptic presented as an injectable solution for intravenous use. It is indicated for the control of partial, generalized tonic‑clonic and myoclonic seizures in both adult and pediatric patients, and is marketed across the European Union.
GNH India supplies Levetiracetam G.L. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

G.L. Pharma Gmbh

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic drug that reduces seizure activity across several seizure types.
  • Partial seizures: helps achieve seizure control in focal onset epilepsy.
  • Generalized tonic‑clonic seizures: reduces the frequency and severity of convulsive episodes.
  • Myoclonic seizures: diminishes rapid, involuntary muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilizing neuronal membranes. This interaction reduces neuronal hyperexcitability and limits the propagation of abnormal electrical activity that underlies seizure generation.

Side Effects

Levetiracetam may cause a range of adverse reactions, most of which are mild to moderate in severity.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Fatigue: generalized tiredness.
  • Headache: mild to moderate cranial pain.
  • Nausea: occasional upset stomach.
  • Irritability: mood changes or agitation.
  • Nasal congestion: mild upper respiratory discomfort.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Mood disorders: depression or suicidal thoughts.
  • Hematologic changes: low blood cell counts.
  • Hepatic dysfunction: elevated liver enzymes.
  • Severe skin reactions: Stevens‑Johnson syndrome.
  • Respiratory depression: difficulty breathing (rare).

Precautions & Warnings

When using Levetiracetam injection, clinicians should consider several safety measures.

  • Renal impairment: adjust dosing or monitor closely.
  • Hepatic dysfunction: assess liver function before initiation.
  • Psychiatric history: monitor for mood changes or suicidal ideation.
  • Pregnancy: evaluate risk‑benefit ratio as safety data are limited.
  • Concomitant CNS depressants: watch for additive sedation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levetiracetam may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: may lower levetiracetam plasma levels.
  • Phenobarbital: can reduce antiepileptic effect.
  • Phenytoin: potential decrease in seizure control.

Moderate Interactions (Monitor Closely)

  • Sedative agents (e.g., benzodiazepines): may enhance CNS depression.
  • Opioids: increased risk of respiratory depression.
  • Alcohol: additive sedation and dizziness.

Frequently Asked Questions

Levetiracetam G.L. is an intravenous antiepileptic medication used to control partial, generalized tonic‑clonic and myoclonic seizures in both adult and pediatric patients. It is administered in hospital or clinical settings where rapid seizure control is required.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilizes neuronal membranes and reduces excessive neuronal firing, thereby decreasing the likelihood of seizure initiation and spread.

The specific dose of Levetiracetam G.L. is determined by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. Healthcare professionals tailor the regimen to achieve optimal seizure control while minimizing side effects.

Safety data for levetiracetam in pregnancy and lactation are limited. Clinicians must weigh potential benefits against unknown risks, and the decision should be individualized. Women who are pregnant or nursing should discuss treatment options with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Levetiracetam has a unique mechanism targeting SV2A, offering broad-spectrum seizure control with relatively few drug‑enzyme interactions. Compared with older agents such as carbamazepine or phenytoin, it often requires less therapeutic drug monitoring and may have a more favorable side‑effect profile, though individual response varies.

Levetiracetam G.L. should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use to maintain stability and sterility.

Levetiracetam G.L. is given by intravenous infusion. The rate and duration of infusion are determined by the prescriber, typically based on the patient’s clinical condition and the recommended concentration for safe administration.

Serious risks include severe allergic reactions (anaphylaxis), mood disorders such as depression or suicidal thoughts, and rare hematologic abnormalities. Patients should be monitored for any signs of these conditions, and treatment should be discontinued if severe reactions occur.

Levetiracetam G.L. is contraindicated in patients with known hypersensitivity to levetiracetam or any component of the formulation. Caution is also advised for individuals with severe renal impairment, as dose adjustments may be required.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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