Product image of Levetiracetam Hexal (Levetiracetam) supplied by GNH India

Levetiracetam Hexal

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Hexal (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Hexal, is an antiepileptic presented as an injection for intravenous use. It treats partial, generalized tonic‑clonic and myoclonic seizures in patients who need rapid seizure control, including emergency and peri‑operative settings.\n\nGNH India supplies Levetiracetam Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, including tertiary care centres and specialty clinics.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic medication indicated for several seizure types.\n\nPartial seizures: reduces the frequency of focal onset seizures.\nGeneralized tonic‑clonic seizures: helps achieve seizure control in primary generalized seizures.\nMyoclonic seizures: decreases the occurrence of myoclonic jerks.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilising neuronal membranes. This action reduces neuronal excitability and limits the propagation of abnormal electrical activity that underlies seizure generation, providing broad-spectrum antiepileptic effects without significant interaction with classic ion channels or receptors.

Side Effects

  • Levetiracetam may cause a range of adverse reactions, most of which are mild to moderate.\n\nCommon Side Effects:\n- Dizziness\n- Fatigue\n- Somnolence\n- Headache\n- Irritability\n- Nausea\n\nSerious or Rare Side Effects:\n- Severe allergic reactions (anaphylaxis)\n- Stevens‑Johnson syndrome or toxic epidermal necrolysis\n- Blood dyscrasias (e.g., neutropenia)\n- Depression or suicidal thoughts\n- Severe skin rash\n- Hepatic injury

Precautions & Warnings

  • When prescribing Levetiracetam Hexal, clinicians should consider several safety aspects.\n\nRenal impairment: adjust dosing based on creatinine clearance.\nHepatic impairment: monitor liver function tests.\nPregnancy: risk unknown; use only if benefit outweighs potential fetal risk.\nConcomitant CNS depressants: may increase sedation.\nMood changes: monitor for depression or suicidal ideation.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Levetiracetam has a relatively low interaction profile, but certain drug combinations require attention.\n\nMajor Interactions (Avoid):\n- Carbamazepine: may reduce levetiracetam plasma levels.\n- Phenytoin: may decrease levetiracetam exposure.\n- Phenobarbital: can lower levetiracetam concentrations.\n\nModerate Interactions (Monitor Closely):\n- CNS depressants (benzodiazepines, opioids): may enhance sedation.\n- Alcohol: can increase central nervous system effects.\n- Valproate: may increase risk of adverse skin reactions.

Frequently Asked Questions

Levetiracetam Hexal is an intravenous formulation of levetiracetam used to treat partial, generalized tonic‑clonic and myoclonic seizures. It is typically employed when rapid seizure control is required, such as in emergency departments, intensive care units, or peri‑operative settings.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. By stabilising synaptic transmission, it reduces neuronal hyper‑excitability and limits the spread of abnormal electrical activity that triggers seizures.

The prescribed dose of Levetiracetam Hexal is determined by the treating physician based on the patient’s age, weight, renal function and seizure type. Dosing regimens are individualized and should follow the clinician’s written order.

Safety data for levetiracetam in pregnancy are limited, and the product is classified as having an unknown pregnancy category. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus. Breastfeeding mothers should consult their healthcare provider.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Levetiracetam offers a broad spectrum of seizure control with minimal enzyme‑inducing properties, resulting in fewer drug‑drug interactions compared with many older antiepileptics such as carbamazepine or phenytoin. Its rapid IV administration also makes it suitable for acute seizure management.

Levetiracetam Hexal must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. If the product reaches room temperature, it may be used within the time frame specified in the labeling, but should be returned to refrigeration promptly.

Levetiracetam Hexal is administered intravenously by a healthcare professional. The injection is given over a short period, typically 5‑15 minutes, depending on the clinical protocol and patient condition. Dilution and infusion rates follow the prescribing information.

Serious risks include severe allergic reactions such as anaphylaxis, rare skin disorders like Stevens‑Johnson syndrome, blood dyscrasias, and significant mood changes including depression or suicidal thoughts. Patients should be monitored closely for any of these events, especially during the initial treatment period.

Levetiracetam Hexal is contraindicated in patients with known hypersensitivity to levetiracetam or any excipients in the formulation. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric disorders, or those who have experienced serious skin reactions to antiepileptic drugs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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