Product image of Levetiracetam Hexal (Levetiracetam) supplied by GNH India

Levetiracetam Hexal

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Hexal (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Hexal, is an anticonvulsant presented as a tablet for oral use. It is used to treat various seizure types in patients with epilepsy.
GNH India supplies Levetiracetam Hexal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal Ag

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug that reduces abnormal neuronal firing in the brain.

  • Partial seizures: helps control focal onset seizures and reduces their frequency.
  • Generalized tonic‑clonic seizures: provides seizure freedom or reduction in patients with primary generalized epilepsy.
  • Myoclonic seizures: diminishes rapid, involuntary muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates vesicle exocytosis, decreasing neuronal excitability and stabilising abnormal electrical activity that underlies seizure generation.

Side Effects

Levetiracetam may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Fatigue: general feeling of tiredness.
  • Somnolence: increased sleepiness.
  • Headache: mild to moderate cranial pain.
  • Irritability: mood changes or agitation.
  • Nausea: upset stomach or urge to vomit.

Serious or Rare Side Effects

  • Severe skin reactions: including Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Suicidal thoughts: emergence of depressive ideation or self‑harm urges.
  • Severe depression: marked mood disturbances requiring medical attention.
  • Blood disorders: such as neutropenia or thrombocytopenia.
  • Hypersensitivity: anaphylaxis or angioedema.
  • Multi‑organ involvement: rare cases of hepatic or renal dysfunction.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Renal impairment: adjust dose based on creatinine clearance.
  • Mood monitoring: watch for depression, anxiety, or suicidal ideation.
  • Discontinuation: avoid abrupt cessation to prevent seizure worsening.
  • Elderly patients: start at lower dose and titrate cautiously.
  • Pregnancy: safety category unknown; weigh benefits against potential risks.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levetiracetam has a relatively low interaction profile, but certain combinations require attention.

Major Interactions (Avoid)

  • Strong enzyme inducers (e.g., carbamazepine, phenytoin, phenobarbital): may reduce levetiracetam plasma levels.
  • Concomitant use with other antiepileptics that lower seizure threshold: could diminish therapeutic effect.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, alcohol): may increase sedation.
  • NSAIDs: possible increase in adverse gastrointestinal effects.
  • Antidepressants: monitor for additive mood changes.
  • Immunosuppressants: observe for altered immune response.

Frequently Asked Questions

Levetiracetam Hexal is prescribed to manage epilepsy. It is effective for partial seizures, generalized tonic‑clonic seizures, and myoclonic seizures, helping to reduce the frequency and severity of seizure episodes in patients diagnosed with these conditions.

Levetiracetam binds to the synaptic vesicle protein SV2A, which regulates neurotransmitter release. By modulating this protein, the drug stabilises neuronal firing, decreasing excessive excitability that can trigger seizures.

The dosage of Levetiracetam Hexal is individualized. A qualified prescriber determines the appropriate amount based on the patient’s age, weight, renal function, seizure type, and response to therapy. Patients should follow the prescribing physician’s instructions exactly.

Levetiracetam’s pregnancy category is listed as unknown, meaning safety data are limited. Healthcare providers weigh potential benefits against possible risks before prescribing to pregnant or nursing women. Consultation with a specialist is recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levetiracetam is distinguished by its unique SV2A mechanism, low potential for drug‑drug interactions, and generally favourable tolerability compared with many older antiepileptics such as carbamazepine or phenytoin, which often require extensive monitoring and have broader interaction profiles.

Levetiracetam Hexal tablets should be stored at room temperature, below 25 °C. Keep them in the original packaging, protect from moisture, and avoid exposure to direct sunlight to maintain product stability.

Levetiracetam Hexal is taken orally, usually with or without food. The tablets are swallowed whole with a glass of water. The exact timing and frequency are set by the prescribing clinician based on the individual treatment plan.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, emergence of suicidal thoughts or severe depression, and rare blood disorders like neutropenia. Patients should seek immediate medical attention if they notice any of these symptoms.

Levetiracetam Hexal is contraindicated in patients with known hypersensitivity to levetiracetam or any of its excipients. Individuals with severe renal impairment may require alternative therapy or dose adjustment, and it should be used with caution in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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