Product image of Levetiracetam Hikma (Levetiracetam) supplied by GNH India

Levetiracetam Hikma

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Hikma (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Hikma, is an antiepileptic presented as an intravenous solution for intravenous use. It is employed to treat epilepsy, including partial and generalized seizures, in patients requiring rapid or controlled seizure management.

GNH India supplies Levetiracetam Hikma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and health‑care institutions worldwide. The company ensures quality assurance, regulatory compliance and reliable cold‑chain logistics for this IV product.

Manufacturer / TM Owner

Hikma Farmacêutica (Portugal), S.A.

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic that acts on seizure activity in the central nervous system.
  • Epilepsy: provides overall seizure control in patients with various seizure types.
  • Partial seizures: reduces frequency and severity of focal seizures.
  • Generalized seizures: helps achieve control of tonic‑clonic and other generalized seizure events.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic vesicle exocytosis, stabilizing neuronal firing and reducing hyper‑excitability. By limiting the release of excitatory neurotransmitters, the drug helps prevent the initiation and propagation of seizure activity without directly affecting ion channels or GABA receptors.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Stevens‑Johnson syndrome
  • Suicidal thoughts or behavior

Precautions & Warnings

When using Levetiracetam, clinicians should consider several safety measures and monitoring requirements.

  • Renal impairment: adjust dosing as needed based on renal function.
  • Hepatic dysfunction: monitor liver enzymes and adjust therapy if required.
  • Pregnancy: use only if potential benefits outweigh potential risks.
  • Concomitant CNS depressants: monitor for additive sedation or respiratory depression.
  • Monitor for behavioral changes: watch for irritability, aggression, or mood swings.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levetiracetam can affect or be affected by other medicines, requiring attention to potential interactions.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma concentrations.
  • Phenobarbital: may lower levetiracetam levels.
  • Phenytoin: may decrease levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Alcohol: may increase central nervous system depression.
  • Other antiepileptics: may require dose adjustments for optimal seizure control.
  • Renal excretion inhibitors: monitor renal function and consider dose modification.

Frequently Asked Questions

Levetiracetam Hikma is an intravenous antiepileptic medication indicated for the treatment of epilepsy, including partial (focal) seizures and generalized seizures. It is used when rapid seizure control is needed or when oral administration is not feasible.

Levetiracetam works by binding to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilizes neuronal firing and reduces hyper‑excitability, helping to prevent the initiation and spread of seizure activity.

The dose of Levetiracetam Hikma is determined by the prescribing clinician based on the patient’s age, weight, renal function, seizure type and severity. No fixed regimen is provided here; the prescriber tailors the dosage to individual therapeutic needs.

Safety data for levetiracetam during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Consultation with a specialist is recommended before initiating therapy.

To order Levetiracetam Hikma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The team then provides pricing, availability, shipping details (including cold‑chain handling) and assists with import documentation.

Levetiracetam offers a distinct mechanism (SV2A binding) and is generally well tolerated compared with older agents such as carbamazepine or valproate, which have more enzyme‑inducing or hepatotoxic potential. It has fewer drug‑drug interactions but may cause behavioral changes in some patients.

Levetiracetam Hikma should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Maintain the cold‑chain during transport and keep the product in its original packaging until use.

Levetiracetam Hikma is administered as an intravenous infusion. The solution is diluted in an appropriate compatible fluid and infused over a period defined by the prescriber, typically ranging from a few minutes to several hours depending on clinical need.

Serious risks include severe allergic reactions such as anaphylaxis, life‑threatening skin conditions like Stevens‑Johnson syndrome, and emergence of suicidal thoughts or behaviors. Patients should be monitored closely for any signs of these events and medical attention sought immediately if they occur.

Levetiracetam Hikma should be avoided in individuals with known hypersensitivity to levetiracetam or any component of the formulation. Patients with severe renal impairment who cannot be dose‑adjusted, or those with uncontrolled psychiatric conditions, should also be evaluated carefully before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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