Product image of Levetiracetam Hospira (Levetiracetam) supplied by GNH India

Levetiracetam Hospira

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Hospira (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Hospira, is an anticonvulsant presented as an intravenous solution for intravenous use. It is indicated for the treatment of partial, generalized tonic‑clonic and myoclonic seizures in patients who require parenteral therapy, and is classified under ATC code N03AX14.

GNH India supplies Levetiracetam Hospira as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide with rigorous quality standards and regulatory compliance.

Manufacturer / TM Owner

Pfizer Europe Ma Eeig

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Indications & Clinical Uses

Levetiracetam is an antiepileptic medication that modulates synaptic neurotransmitter release to control seizure activity.

  • Partial seizures: reduces frequency and severity of focal onset seizures.
  • Generalized tonic‑clonic seizures: helps achieve seizure control in primary generalized seizures.
  • Myoclonic seizures: decreases myoclonic jerks and improves overall seizure management.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter exocytosis. This interaction modulates calcium‑dependent vesicle release, stabilizing neuronal firing and reducing hyper‑excitability associated with epileptic activity. The precise downstream effects are not fully understood, but the SV2A binding is considered central to its anticonvulsant properties.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness: transient sensation of lightheadedness.
  • Fatigue: general tiredness or lack of energy.
  • Headache: mild to moderate cranial pain.
  • Nausea: feeling of stomach upset.
  • Irritability: mood changes or increased agitation.
  • Somnolence: drowsiness or sleepiness.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: severe skin blistering.
  • Blood dyscrasias: neutropenia or thrombocytopenia.
  • Mood disturbances: depression or suicidal thoughts.
  • Hepatic dysfunction: elevated liver enzymes.
  • Respiratory depression: difficulty breathing (rare).

Precautions & Warnings

When using Levetiracetam Hospira, clinicians should consider several precautionary measures to ensure safe administration.

  • Renal impairment: adjust dosing or monitor renal function.
  • Hepatic dysfunction: evaluate liver status before use.
  • Pregnancy: category B, use only if benefit outweighs risk.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Psychiatric history: watch for mood changes or suicidal ideation.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenobarbital: may decrease levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Valproic acid: may increase risk of adverse CNS effects.
  • CNS depressants (e.g., benzodiazepines): may enhance sedation.
  • Immunosuppressants (e.g., cyclosporine): monitor for altered drug levels.
  • Oral contraceptives: may have reduced efficacy, advise alternative contraception.

Frequently Asked Questions

Levetiracetam Hospira is an intravenous antiepileptic used to treat partial, generalized tonic‑clonic and myoclonic seizures in patients who require parenteral therapy, providing rapid seizure control when oral administration is not feasible.

Levetiracetam binds to the synaptic vesicle protein SV2A, modulating calcium‑dependent neurotransmitter release. This stabilizes neuronal firing and reduces the hyper‑excitability that underlies seizure activity.

The dosing regimen for Levetiracetam Hospira is determined by the prescribing clinician based on the patient’s age, weight, renal function and seizure type. No fixed dose is provided here; the prescriber sets the appropriate infusion rate and total daily amount.

Levetiracetam is classified as Pregnancy Category B, indicating that animal studies have not shown risk but there are no adequate human studies. It may be used during pregnancy only if the potential benefit justifies the risk. Limited data are available for breastfeeding, so clinicians should weigh benefits against possible exposure to the infant.

To order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where applicable) and necessary import documentation.

Levetiracetam offers a favorable safety profile and minimal drug‑enzyme interactions compared with older agents such as phenytoin or carbamazepine. It does not require routine serum level monitoring and is less likely to cause hepatic enzyme induction, making it a convenient option for intravenous seizure management.

Levetiracetam Hospira should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the solution. Once removed from refrigeration, use within the time frame specified in the product labeling and keep the vial in its original packaging.

The product is supplied as an intravenous solution that is administered by slow infusion into a vein, typically over 15 minutes to several hours depending on the clinical protocol. Administration should be performed by qualified healthcare personnel in a setting equipped for IV therapy.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, blood dyscrasias (e.g., neutropenia), significant mood disturbances including depression or suicidal thoughts, and rare cases of hepatic dysfunction. Prompt medical attention is required if any of these events occur.

Patients with known hypersensitivity to levetiracetam or any component of the formulation should avoid its use. Caution is also advised for individuals with severe renal impairment, as dose adjustment may be required, and for those with a history of serious psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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