Product image of Levetiracetam Intrapharm Laboratories (Levetiracetam) supplied by GNH India

Levetiracetam Intrapharm Laboratories

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Intrapharm Laboratories (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Intrapharm Laboratories, is an anticonvulsant presented as a intravenous solution for intravenous use. It treats partial‑onset, myoclonic, and primary generalized tonic‑clonic seizures as adjunct therapy in patients with epilepsy.

GNH India supplies Levetiracetam Intrapharm Laboratories as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Esteve Pharmaceuticals Gmbh

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Indications & Clinical Uses

Levetiracetam is an antiepileptic agent used as adjunct therapy for several seizure types.

  • Partial‑onset seizures: reduces seizure frequency when added to existing therapy.
  • Myoclonic seizures: helps control rapid, brief muscle jerks in appropriate patients.
  • Primary generalized tonic‑clonic seizures: decreases seizure occurrence as part of combination treatment.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release. This interaction reduces neuronal hyperexcitability and stabilises synaptic transmission, thereby diminishing the likelihood of seizure propagation in the central nervous system.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness: transient sensation of lightheadedness or unsteadiness.
  • Fatigue: feeling unusually tired or low energy.
  • Headache: mild to moderate head pain.
  • Irritability: increased agitation or mood changes.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Stevens‑Johnson syndrome: rare skin and mucous membrane disorder.
  • Suicidal thoughts: emergence of depressive symptoms or suicidal ideation.

Precautions & Warnings

When prescribing levetiracetam, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust dose based on creatinine clearance.
  • Hepatic dysfunction: monitor liver function tests periodically.
  • Psychiatric history: observe for mood changes or depression.
  • Concomitant CNS depressants: use caution as additive sedation may occur.
  • Pregnancy and lactation: evaluate risk‑benefit, as safety data are limited.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenytoin: may decrease levetiracetam exposure.
  • Phenobarbital: can lower levetiracetam concentrations.

Moderate Interactions (Monitor Closely)

  • Valproic acid: may increase levetiracetam levels modestly.
  • Rifampin: may enhance clearance of levetiracetam.
  • Oral contraceptives: monitor for reduced efficacy of contraceptives.

Frequently Asked Questions

Levetiracetam Intrapharm Laboratories is an intravenous antiepileptic medication used as adjunct therapy for partial‑onset seizures, myoclonic seizures, and primary generalized tonic‑clonic seizures in patients with epilepsy who require additional seizure control.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action reduces neuronal hyperexcitability and helps stabilise synaptic activity, thereby lowering the likelihood of seizure generation and spread.

The specific dose of levetiracetam is determined by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for levetiracetam during pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative therapies when appropriate. Breastfeeding decisions should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Compared with older antiepileptics such as carbamazepine or valproate, levetiracetam has a distinct mechanism (SV2A binding) and generally fewer drug‑enzyme interactions, which can simplify combination therapy. However, individual response and side‑effect profiles vary, so choice of therapy should be personalised.

Levetiracetam intravenous solution should be stored at ambient temperature, protected from light and moisture, and kept in its original packaging. Do not freeze the solution; inspect for particulate matter before administration.

Levetiracetam is given by intravenous infusion. The infusion rate and total daily dose are prescribed by the treating physician, who may adjust based on renal function and clinical response. Administration should follow aseptic technique and standard IV infusion guidelines.

Serious risks include severe allergic reactions such as rash, swelling, or breathing difficulty, rare skin conditions like Stevens‑Johnson syndrome, and emergence of suicidal thoughts or depressive symptoms. Prompt medical evaluation is required if any of these occur.

Levetiracetam is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting medications that significantly alter its plasma levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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