Product image of Levetiracetam Krka (Levetiracetam) supplied by GNH India

Levetiracetam Krka

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Krka (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Krka, is an anticonvulsant presented as an oral tablet for oral use. It treats partial, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy.

GNH India supplies Levetiracetam Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Levetiracetam is used to manage seizure disorders by stabilizing neuronal activity.

  • Partial seizures: Reduces frequency and severity of focal onset seizures.
  • Generalized tonic‑clonic seizures: Controls convulsive episodes in generalized epilepsy.
  • Myoclonic seizures: Decreases sudden muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and reducing neuronal hyper‑excitability. This interaction stabilizes synaptic transmission without significant effects on ion channels or G‑protein pathways, leading to decreased propagation of abnormal electrical activity. The downstream effect involves attenuation of calcium‑dependent release mechanisms, providing broad‑spectrum seizure control in partial, generalized tonic‑clonic and myoclonic epilepsy.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Fatigue: feeling unusually tired or low energy.
  • Headache: mild to moderate cranial pain.
  • Irritability: increased mood swings or agitation.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Mood changes: depression, suicidal thoughts, or aggressive behavior.
  • Hematologic abnormalities: low blood cell counts.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several safety precautions.

  • Renal impairment: adjust dose based on creatinine clearance.
  • History of psychiatric disorders: monitor for mood changes.
  • Concomitant CNS depressants: assess additive sedation risk.
  • Pregnancy: use only if potential benefit justifies risk, as safety data are limited.
  • Lactation: evaluate infant exposure, benefits vs risks.
  • Store below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenobarbital: may decrease levetiracetam exposure.
  • Phenytoin: may lower levetiracetam concentrations.

Moderate Interactions (Monitor Closely)

  • Valproic acid: may increase levetiracetam levels, monitor for toxicity.
  • Alcohol: additive CNS depression, advise caution.
  • Other antiepileptic drugs: assess for synergistic side effects.

Frequently Asked Questions

Levetiracetam Krka is prescribed to treat epilepsy. It is effective for controlling partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures, helping to reduce the frequency and intensity of seizure episodes in patients diagnosed with these seizure types.

Levetiracetam works by binding to the synaptic vesicle protein SV2A, which modulates the release of neurotransmitters. This action stabilizes neuronal firing and lowers hyper‑excitability, thereby preventing the spread of abnormal electrical activity that leads to seizures.

The dose of levetiracetam is individualized. A qualified prescriber determines the appropriate amount based on the patient’s age, weight, renal function, seizure type, and response to therapy. Patients should follow the prescribing information provided by their healthcare professional.

Safety data for levetiracetam in pregnancy are limited, and the drug is classified as pregnancy category unknown. It should be used only if the potential benefit outweighs the risk. During breastfeeding, the medication may pass into milk; a clinician should assess the risk‑benefit ratio for the infant.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Levetiracetam offers a broad spectrum of seizure control with a relatively favorable interaction profile compared with many enzyme‑inducing antiepileptics. It does not require routine therapeutic drug monitoring and is generally well tolerated, though individual response and side‑effect profiles may differ from agents such as carbamazepine, valproate or phenytoin.

Levetiracetam Krka should be stored at temperatures below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Levetiracetam Krka is administered orally, typically as a tablet that can be swallowed whole with water. The exact dosing schedule—once daily, twice daily, or more—depends on the prescriber’s instructions and the patient’s clinical needs.

Serious risks include severe allergic reactions (such as rash, swelling, or breathing difficulty), significant mood changes (including depression, suicidal thoughts, or aggression), and rare hematologic or hepatic abnormalities. Patients should seek immediate medical attention if any of these symptoms arise.

Levetiracetam is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is also advised for patients with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting medications that may markedly reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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