Product image of Levetiracetam Krka (Levetiracetam) supplied by GNH India

Levetiracetam Krka

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Krka (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Krka, is an anticonvulsant presented as an oral tablet for oral use. It treats partial, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy.
GNH India supplies Levetiracetam Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic drug used to control various seizure types.
  • Partial seizures: reduces frequency and severity of focal onset seizures.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes.
  • Myoclonic seizures: diminishes rapid, involuntary muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilizing neuronal membranes. This action reduces abnormal neuronal firing and lowers the likelihood of seizure propagation across the central nervous system.

Side Effects

Levetiracetam may cause a range of adverse reactions.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dizziness: sensation of light‑headedness or loss of balance.
  • Headache: mild to moderate cranial pain.
  • Irritability: increased mood swings or agitation.
  • Nausea: upset stomach or urge to vomit.
  • Nasal congestion: blocked or runny nose.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Mood changes: depression, suicidal thoughts, or aggressive behavior.
  • Blood disorders: low white blood cells or platelets.
  • Liver dysfunction: jaundice or abnormal liver enzymes.
  • Skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

  • Before initiating therapy, consider the following precautions.
  • Renal function: dose may need adjustment in patients with impaired kidney function.
  • Pregnancy: safety data are limited; discuss risks with a healthcare professional.
  • Psychiatric history: monitor for mood changes or suicidal ideation.
  • Concomitant CNS depressants: may increase sedation or dizziness.
  • Alcohol use: can enhance central nervous system effects.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levetiracetam can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenobarbital: can lower levetiracetam concentrations.
  • Phenytoin: may decrease levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: levetiracetam may reduce hormonal efficacy.
  • Sedatives or hypnotics: increased risk of drowsiness.
  • Antidepressants: potential for heightened mood alterations.

Frequently Asked Questions

Levetiracetam Krka is prescribed to manage partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients diagnosed with epilepsy. It helps reduce the frequency and intensity of seizure episodes across these seizure types.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. By stabilizing neuronal firing and decreasing excessive excitability, it lowers the likelihood of seizure initiation and spread within the brain.

The appropriate dose of Levetiracetam Krka is determined by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Safety data for levetiracetam in pregnancy are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levetiracetam offers a distinct mechanism by targeting SV2A, which differs from sodium‑channel blockers like carbamazepine or GABA‑enhancers such as valproate. It is generally well tolerated, has fewer drug‑enzyme interactions, and can be used as monotherapy or adjunct therapy depending on the clinical scenario.

Levetiracetam Krka tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Levetiracetam Krka is taken orally, usually with or without food. Tablets should be swallowed whole with water and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include severe allergic reactions (e.g., rash, swelling, breathing difficulty), mood disturbances such as depression or suicidal thoughts, and rare blood disorders. Patients should seek immediate medical attention if any of these symptoms occur.

Levetiracetam Krka is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is also advised for patients with severe renal impairment, as dose adjustments may be required.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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