Product image of Levetiracetam Krka (Levetiracetam) supplied by GNH India

Levetiracetam Krka

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Krka (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Krka, is an antiepileptic presented as an oral tablet for oral use. It is indicated for the treatment of various seizure types in patients diagnosed with epilepsy.

GNH India supplies Levetiracetam Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug that reduces abnormal neuronal firing in the central nervous system.

  • Partial onset seizures: helps control focal seizures that start in one area of the brain.
  • Generalized tonic‑clonic seizures: reduces the frequency and severity of convulsive seizures affecting the whole brain.
  • Myoclonic seizures: diminishes sudden, brief muscle jerks characteristic of myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic vesicle exocytosis, decreasing neuronal excitability and stabilizing abnormal electrical activity that leads to seizures.

Side Effects

Levetiracetam may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Somnolence: increased sleepiness or fatigue.
  • Headache: mild to moderate head pain.
  • Irritability: mood changes or agitation.
  • Nausea: occasional stomach upset.
  • Fatigue: reduced energy levels.

Serious or Rare Side Effects

  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Depression or suicidal thoughts: mood disturbances requiring immediate attention.
  • Severe allergic reactions: including anaphylaxis.
  • Blood disorders: rare cases of leukopenia or thrombocytopenia.
  • Respiratory depression: uncommon but potentially life‑threatening breathing difficulty.

Precautions & Warnings

Before initiating levetiracetam therapy, several safety considerations should be addressed.

  • Renal impairment: dose may need adjustment based on kidney function.
  • Hepatic impairment: monitor liver enzymes and consider dose modification.
  • Pregnancy: risk category unknown; discuss potential benefits and risks with a healthcare provider.
  • Concomitant CNS depressants: may enhance sedation or dizziness.
  • Psychiatric symptoms: monitor for mood changes, depression, or suicidal ideation.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levetiracetam can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma concentrations.
  • Phenytoin: may lower levetiracetam levels, decreasing seizure control.
  • Phenobarbital: can decrease levetiracetam exposure, risking breakthrough seizures.

Moderate Interactions (Monitor Closely)

  • Alcohol: may increase central nervous system depression and impair coordination.
  • Other antiepileptics: combined use may require dose adjustments to maintain efficacy.
  • Renal excretion inhibitors: monitor renal function as they may affect levetiracetam clearance.

Frequently Asked Questions

Levetiracetam Krka is prescribed to manage partial onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients with epilepsy. It helps reduce the frequency and severity of these seizure types by stabilizing abnormal neuronal activity.

Levetiracetam binds to the synaptic vesicle protein SV2A, which regulates neurotransmitter release. This binding modulates vesicle exocytosis, decreasing neuronal excitability and preventing the rapid, uncontrolled firing that leads to seizures.

The dosage of Levetiracetam Krka is individualized by the prescribing clinician based on factors such as seizure type, patient age, renal function, and response to therapy. Patients should follow the specific dosing instructions provided by their healthcare professional.

The safety of levetiracetam during pregnancy and lactation has not been definitively established. Healthcare providers will weigh potential benefits against unknown risks and may recommend alternative treatments or close monitoring if use is considered necessary.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levetiracetam offers a distinct mechanism by targeting SV2A, which differs from sodium‑channel blockers like carbamazepine or GABA‑enhancers such as valproate. It generally has fewer drug‑enzyme interactions, a favorable tolerability profile, and can be used as monotherapy or adjunctive therapy.

Levetiracetam Krka tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Levetiracetam Krka is taken orally, usually with or without food, as directed by the prescriber. Tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include severe skin reactions (e.g., Stevens‑Johnson syndrome), mood disturbances such as depression or suicidal thoughts, and rare blood disorders. Patients should seek immediate medical attention if they notice rash, mood changes, or signs of infection.

Levetiracetam Krka is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for patients with severe renal impairment, uncontrolled psychiatric conditions, or those taking interacting medications without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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