Product image of Levetiracetam Neuraxpharm (Levetiracetam) supplied by GNH India

Levetiracetam Neuraxpharm

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Neuraxpharm (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Neuraxpharm, is an anticonvulsant (pyrrolidine derivative) presented as an oral tablet for oral use. It is used to treat partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy.

GNH India supplies Levetiracetam Neuraxpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm Uk Limited

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug that modulates neuronal excitability in various seizure types.

  • Partial‑onset seizures: reduces the frequency of focal seizure episodes.
  • Generalized tonic‑clonic seizures: helps prevent convulsive seizures in generalized epilepsy.
  • Myoclonic seizures: decreases myoclonic jerks in appropriate epilepsy syndromes.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic vesicle exocytosis, leading to reduced neuronal hyper‑excitability and stabilization of neuronal firing, which underlies its anticonvulsant effect.

Side Effects

Levetiracetam may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Dizziness
  • Somnolence
  • Fatigue
  • Headache
  • Irritability
  • Nausea

Serious or Rare Side Effects

  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Suicidal thoughts or behavior
  • Severe depression or mood changes
  • Blood dyscrasias (e.g., neutropenia, thrombocytopenia)
  • Hypersensitivity reactions including anaphylaxis
  • Multi‑organ involvement (e.g., hepatic or renal impairment)

Precautions & Warnings

Levetiracetam requires careful monitoring in certain patient groups and clinical situations.

  • Renal impairment: adjust dose based on renal function.
  • History of psychiatric disorders: monitor for mood changes.
  • Concomitant CNS depressants: assess additive sedation.
  • Pregnancy: use only if benefit outweighs risk.
  • Elderly patients: start at lower dose and titrate slowly.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Levetiracetam can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenytoin: may decrease levetiracetam exposure.
  • Phenobarbital: may lower levetiracetam concentrations.
  • Rifampin: induces metabolism, reducing efficacy.
  • Other enzyme‑inducing antiepileptics: may diminish therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive CNS depression.
  • Sedative antihistamines: may increase drowsiness.
  • Opioids: monitor for enhanced sedation.
  • CNS depressants (e.g., benzodiazepines): watch for excessive sedation.
  • Oral contraceptives: levetiracetam may reduce efficacy; consider alternative contraception.

Frequently Asked Questions

Levetiracetam Neuraxpharm is prescribed to manage epilepsy. It is indicated for partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures, helping to reduce the frequency and severity of seizure episodes in patients diagnosed with these seizure types.

Levetiracetam binds to the synaptic vesicle protein SV2A, which plays a crucial role in neurotransmitter release. By modulating SV2A activity, the drug stabilizes neuronal firing and decreases excessive neuronal excitability, thereby providing its anticonvulsant effect.

The dosage of Levetiracetam Neuraxpharm is individualized. A qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s age, renal function, seizure type, and clinical response. Patients should follow the prescribing clinician’s instructions precisely.

Safety data for levetiracetam in pregnancy and lactation are limited. It is classified as pregnancy category unknown, and use is recommended only when the potential benefit to the mother outweighs any possible risk to the fetus. Breastfeeding mothers should consult their healthcare provider before continuing therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levetiracetam offers a distinct mechanism by targeting SV2A, which differs from sodium‑channel blockers like carbamazepine or GABA‑enhancers such as valproate. It generally has fewer drug‑enzyme interactions, a favorable tolerability profile, and does not require routine blood‑level monitoring, making it a convenient option for many patients.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original packaging to protect from moisture and light. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Levetiracetam Neuraxpharm is taken orally. Swallow the tablet whole with a glass of water; it may be taken with or without food. Doses are usually divided throughout the day as directed by the prescriber to maintain stable blood levels.

Serious adverse events include severe skin reactions such as Stevens‑Johnson syndrome, suicidal ideation or behavior, marked depression, and rare blood disorders like neutropenia or thrombocytopenia. Patients should seek immediate medical attention if they notice rash, mood changes, or unexplained bruising.

Levetiracetam is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for patients with severe renal impairment, as dose adjustment may be required, and for those with a history of serious psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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