Product image of Levetiracetam Noridem Enterprises Limited (Levetiracetam) supplied by GNH India

Levetiracetam Noridem Enterprises Limited

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Noridem Enterprises Limited (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Noridem Enterprises Limited, is an antiepileptic presented as an injection for intravenous use. It treats partial seizures, generalized tonic‑clonic seizures and myoclonic seizures in patients who require rapid seizure control.

GNH India supplies Levetiracetam Noridem Enterprises Limited as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Noridem Enterprises Ltd

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Indications & Clinical Uses

Levetiracetam is an antiepileptic medication used to manage various seizure types.

  • Partial seizures: reduces the frequency and severity of focal onset seizures.
  • Generalized tonic‑clonic seizures: helps control convulsive episodes across the brain.
  • Myoclonic seizures: diminishes sudden muscle jerks associated with this seizure type.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilizing neuronal membranes. This interaction reduces neuronal hyperexcitability, thereby decreasing the likelihood of seizure initiation and propagation across neural networks.

Side Effects

Levetiracetam may cause a range of adverse reactions, which vary in frequency and severity.

Common Side Effects

  • Drowsiness: mild to moderate sedation.
  • Dizziness: sensation of light‑headedness.
  • Headache: transient cranial discomfort.
  • Fatigue: reduced energy levels.
  • Irritability: mood changes or agitation.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Mood disorders: depression or suicidal thoughts.
  • Hematologic abnormalities: low blood cell counts.
  • Hepatic dysfunction: elevated liver enzymes.
  • Severe skin reactions: Stevens‑Johnson syndrome.
  • Respiratory depression: difficulty breathing (rare).

Precautions & Warnings

Before using Levetiracetam injection, consider the following safety measures.

  • Renal impairment: dose may need adjustment in reduced kidney function.
  • Hepatic disease: monitor liver function tests regularly.
  • Pregnancy: category C; weigh benefits against potential risks.
  • Breastfeeding: assess infant exposure and benefits.
  • Concomitant CNS depressants: may enhance sedation.
  • Storage: Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenobarbital: can lower levetiracetam concentrations.

Moderate Interactions (Monitor Closely)

  • Valproic acid: may increase risk of central nervous system side effects.
  • Fluoroquinolone antibiotics: potential for heightened neurotoxicity.
  • Opioids: additive sedation or respiratory depression.
  • Alcohol: may exacerbate dizziness and drowsiness.
  • Other antiepileptics: monitor for cumulative adverse effects.

Frequently Asked Questions

Levetiracetam is prescribed to control seizures, including partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It is used in patients with epilepsy who need effective seizure reduction, particularly when rapid intravenous administration is required.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilizes neuronal firing and reduces hyperexcitability, thereby lowering the likelihood of seizure initiation and spread throughout the brain.

The dosage of Levetiracetam is individualized by the prescribing clinician based on the patient's age, weight, renal function, and seizure type. The prescriber determines the appropriate dose and infusion rate for each patient.

Levetiracetam is classified as pregnancy category C, indicating that risk cannot be ruled out. It should only be used if the potential benefit justifies the potential risk to the fetus. Breastfeeding mothers should discuss infant exposure with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed), and import documentation.

Levetiracetam offers a distinct mechanism by targeting SV2A, which differs from sodium‑channel blockers like carbamazepine. It has a relatively favorable interaction profile and does not require routine therapeutic drug monitoring, making it a convenient option for many patients.

Levetiracetam injection should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability and sterility.

Levetiracetam is given intravenously by slow infusion, typically over 15 minutes, under the supervision of qualified healthcare personnel. The exact infusion rate and volume are determined by the prescribing clinician.

Serious risks include severe allergic reactions (anaphylaxis), mood disturbances such as depression or suicidal thoughts, and rare hematologic or hepatic abnormalities. Patients should be monitored closely for any new or worsening symptoms.

Levetiracetam is contraindicated in patients with known hypersensitivity to the drug or any of its excipients. Caution is advised for individuals with severe renal impairment, as dose adjustments are required, and for those with uncontrolled psychiatric conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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