Product image of Levetiracetam Ratiopharm (Levetiracetam) supplied by GNH India

Levetiracetam Ratiopharm

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Ratiopharm (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Ratiopharm, is an anticonvulsant presented as an oral tablet for oral use. It is used to treat partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy.

GNH India supplies Levetiracetam Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide and complies with EU regulatory standards.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Levetiracetam is an anticonvulsant indicated for several seizure types in epilepsy.

  • Partial‑onset seizures: reduces the frequency of focal seizures and helps achieve seizure control.
  • Generalized tonic‑clonic seizures: decreases the occurrence of bilateral convulsive episodes.
  • Myoclonic seizures: lowers the rate of rapid, brief muscle jerks associated with epilepsy.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilising neuronal membranes. This interaction reduces abnormal neuronal firing and diminishes overall neuronal excitability, thereby preventing the propagation of seizure activity in the central nervous system.

Side Effects

Levetiracetam may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Fatigue: feeling unusually tired or low in energy.
  • Headache: mild to moderate cranial pain.
  • Nausea: upset stomach or urge to vomit.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis): rapid swelling, difficulty breathing.
  • Stevens‑Johnson syndrome: serious skin rash with blistering.
  • Suicidal ideation: thoughts of self‑harm or depression.
  • Blood dyscrasias: abnormal blood cell counts.
  • Severe skin rash: extensive erythema or peeling.
  • Depression or mood changes: significant emotional disturbances.

Precautions & Warnings

When prescribing levetiracetam, clinicians should consider several safety factors.

  • Renal impairment: adjust dose based on renal function.
  • Hepatic dysfunction: monitor liver enzymes and consider dose modification.
  • Psychiatric symptoms: observe for mood changes, depression or suicidal thoughts.
  • Pregnancy: risk unknown; use only if benefits outweigh potential risks.
  • Concomitant CNS depressants: may increase sedation or dizziness.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Levetiracetam can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: induces metabolism, lowering levetiracetam levels.
  • Phenobarbital: increases clearance, reducing therapeutic effect.
  • Phenytoin: accelerates metabolism, potentially leading to seizure breakthrough.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance central nervous system depression.
  • Opioids: combined use can increase sedation.
  • Antidepressants: possible additive effects on mood or cognition.

Frequently Asked Questions

Levetiracetam Ratiopharm is an antiepileptic medication prescribed to control partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients diagnosed with epilepsy. It helps reduce seizure frequency and improve overall quality of life when taken as directed by a healthcare professional.

Levetiracetam binds to the synaptic vesicle protein SV2A, influencing neurotransmitter release and stabilising neuronal membranes. This action diminishes abnormal neuronal firing, thereby lowering the excitability that leads to seizure activity.

The dosage of levetiracetam is individualized by the prescribing clinician based on factors such as the patient’s age, weight, renal function and seizure type. The prescriber determines the appropriate starting dose and any subsequent adjustments.

Safety data for levetiracetam in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Physicians should discuss the available evidence with the patient and consider alternative therapies when appropriate.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older agents such as carbamazepine or phenytoin, levetiracetam has a simpler pharmacokinetic profile, fewer enzyme‑inducing interactions and a lower risk of hepatic toxicity. Individual response and tolerability vary, so the choice of therapy is tailored to each patient’s clinical situation.

Store the tablets at room temperature, below 25 °C, in the original packaging. Protect them from moisture and direct sunlight to maintain stability throughout the product’s shelf life.

Levetiracetam is taken orally, usually as whole tablets, with or without food. Patients should follow the prescribing clinician’s instructions regarding timing and whether the dose should be divided throughout the day.

Serious adverse events, although rare, can include severe allergic reactions such as anaphylaxis, skin disorders like Stevens‑Johnson syndrome, and the emergence of suicidal thoughts or behavior. Immediate medical attention is required if any of these symptoms occur.

Individuals with a known hypersensitivity to levetiracetam or any of its excipients should avoid the drug. Caution is also advised for patients with severe renal impairment, as dose adjustment may be necessary, and for those with uncontrolled psychiatric conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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