Product image of Levetiracetam Stada Arzneimittel Ag (Levetiracetam) supplied by GNH India

Levetiracetam Stada Arzneimittel Ag

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Stada Arzneimittel Ag (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Stada Arzneimittel Ag, is an antiepileptic presented as an oral tablet for systemic administration. It is indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients diagnosed with epilepsy. The medication works by modulating neuronal excitability, helping to reduce seizure frequency.

GNH India supplies Levetiracetam Stada Arzneimittel Ag as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory support for cross‑border distribution.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic medication used to control seizure activity across several epilepsy syndromes.
  • Partial‑onset seizures: reduces the frequency of focal seizures in patients with epilepsy.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes and associated injuries.
  • Myoclonic seizures: decreases the occurrence of rapid muscle jerks characteristic of this seizure type.
  • Adjunct therapy for refractory epilepsy: may be used when other agents are insufficient.
  • Status epilepticus (adjunct): may be considered as add‑on therapy in acute settings.
  • Adjunct in pediatric epilepsy: used under specialist supervision to manage seizures in children.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates vesicle exocytosis, stabilizing neuronal membranes and decreasing hyper‑synchronised firing. By reducing calcium‑dependent release of excitatory neurotransmitters, the drug lowers neuronal excitability and interrupts the propagation of seizure activity throughout the central nervous system. The precise downstream effects are not fully understood, but the overall result is a net anticonvulsant action without significant interaction with G‑protein coupled receptors.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis, Stevens‑Johnson syndrome)
  • Mood changes including depression or suicidal thoughts
  • Severe skin rash
  • Blood dyscrasias (e.g., neutropenia, thrombocytopenia)

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several safety measures.

  • Renal impairment: adjust dose based on creatinine clearance.
  • Mood monitoring: observe for depression or suicidal ideation.
  • Discontinuation: taper gradually to avoid seizure worsening.
  • Pregnancy: risk unknown, use only if benefit outweighs potential risk.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Store at room temperature below 25°C: keep in original container, protect from moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Carbamazepine: may lower levetiracetam plasma levels.
  • Phenytoin: can decrease levetiracetam concentrations.
  • Phenobarbital: may reduce levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Valproic acid: potential for increased side‑effects.
  • Other antiepileptics: additive central nervous system depression.
  • Oral contraceptives: possible reduction in hormonal efficacy.

Frequently Asked Questions

Levetiracetam is prescribed to treat several types of epileptic seizures, including partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It is used in both adult and pediatric patients when seizure control is required, often as part of a broader antiepileptic regimen.

Levetiracetam binds to the synaptic vesicle protein SV2A, which regulates neurotransmitter release. This binding modulates vesicle exocytosis, reducing the release of excitatory neurotransmitters and stabilising neuronal firing, thereby decreasing the likelihood of seizure propagation.

The appropriate dose of Levetiracetam is set by the prescribing clinician based on the patient’s age, weight, renal function, seizure type, and response to therapy. Dosage adjustments may be required for patients with impaired kidney function or when used in combination with other antiepileptic drugs.

Levetiracetam’s pregnancy category is listed as unknown, meaning that potential risks cannot be ruled out. It should only be used during pregnancy or lactation if the expected benefit to the mother outweighs possible risks to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with many older antiepileptics, Levetiracetam has a relatively simple pharmacokinetic profile, few drug‑enzyme interactions, and does not require routine therapeutic drug monitoring. However, it may be associated with behavioral side effects that are less common with drugs such as carbamazepine or valproate.

Levetiracetam tablets should be stored at room temperature below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Levetiracetam is taken orally, usually as a tablet swallowed whole with water. It can be taken with or without food. The exact schedule—once, twice or three times daily—depends on the prescriber’s instructions and the individual patient’s therapeutic needs.

Serious adverse events include severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, significant mood alterations like depression or suicidal thoughts, and rare blood disorders such as neutropenia or thrombocytopenia. Patients should seek immediate medical attention if they notice rash, mood changes, or signs of infection.

Levetiracetam is contraindicated in individuals with known hypersensitivity to the drug or any of its excipients. Caution is advised for patients with severe renal impairment who may require dose reduction, and for those with a history of serious psychiatric disorders, as the medication can exacerbate mood symptoms.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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