Product image of Levetiracetam Stragen (Levetiracetam) supplied by GNH India

Levetiracetam Stragen

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Stragen (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Stragen, is an anticonvulsant presented as an intravenous solution for intravenous use. It is employed to treat partial‑onset seizures, generalized tonic‑clonic seizures and myoclonic seizures in patients with epilepsy and is commonly used in hospital settings.

GNH India supplies Levetiracetam Stragen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stragen Nordic A/S

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic drug used to control various seizure types.
  • Partial‑onset seizures: reduces seizure frequency and severity in focal epilepsy.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes in patients with generalized epilepsy.
  • Myoclonic seizures: decreases sudden muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates vesicle exocytosis, stabilizing neuronal membranes and decreasing hyper‑synchronised firing. By reducing synaptic release of excitatory neurotransmitters, the drug lowers neuronal excitability and helps prevent the initiation and propagation of epileptic discharges. The precise downstream pathways remain under investigation, but the overall effect is a net attenuation of seizure activity without significant impact on GABA or glutamate receptor binding.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Somnolence
  • Nausea
  • Irritability

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis, angioedema)
  • Stevens‑Johnson syndrome or other severe skin rashes
  • Blood dyscrasias such as neutropenia or thrombocytopenia
  • Suicidal thoughts or behavior
  • Respiratory depression
  • Severe skin rash requiring immediate medical attention

Precautions & Warnings

  • When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure safe use.
  • Renal impairment: adjust dose in patients with reduced renal function.
  • Hepatic impairment: monitor liver function tests regularly.
  • Pregnancy: safety not established; weigh benefits against potential risks.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Behavioral changes: observe for mood alterations, aggression, or suicidal ideation.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levetiracetam has a low potential for drug‑drug interactions, but certain combinations require attention.

Major Interactions (Avoid)

  • Phenobarbital: may lower levetiracetam plasma concentrations, reducing efficacy.
  • Carbamazepine: enzyme induction can decrease levetiracetam levels.
  • Valproic acid: may increase levetiracetam concentrations, raising risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • Other antiepileptic drugs: additive CNS depression may occur.
  • Alcohol: can enhance sedation and dizziness.
  • Carbapenem antibiotics: may reduce levetiracetam levels, requiring dose adjustment.

Frequently Asked Questions

Levetiracetam Stragen is an intravenous antiepileptic medication indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures and myoclonic seizures in patients diagnosed with epilepsy. It is administered in clinical settings where rapid control of seizure activity is required.

Levetiracetam exerts its effect by binding to the synaptic vesicle protein SV2A, which plays a crucial role in regulating neurotransmitter release. This binding modulates vesicle exocytosis, leading to reduced excitatory neurotransmission and decreased neuronal hyper‑excitability, thereby helping to prevent seizure generation and spread.

The exact dose of Levetiracetam Stragen is determined by the prescribing clinician based on individual patient factors such as age, weight, renal function, severity of seizures, and response to therapy. No fixed regimen is provided here; dosing must follow the prescriber’s medical judgment and local guidelines.

Safety of levetiracetam in pregnancy and lactation has not been definitively established. The medication should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and decisions should be made in consultation with a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Levetiracetam Stragen. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and necessary import documentation.

Levetiracetam is distinguished by its unique SV2A binding mechanism, a relatively low potential for pharmacokinetic drug interactions, and a rapid onset of action when given intravenously. Compared with older agents such as phenytoin or carbamazepine, it often requires less therapeutic drug monitoring and may have a more favorable side‑effect profile for many patients.

Levetiracetam Stragen should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the solution from direct light and moisture, and avoid freezing. Inspect the container for any particulate matter before use and discard any product that appears discolored or compromised.

Levetiracetam Stragen is administered by intravenous infusion. The infusion rate and total daily dose are determined by the treating physician, taking into account the patient’s clinical condition and renal function. The solution should be administered using aseptic technique and compatible IV equipment.

Serious risks include severe allergic reactions such as anaphylaxis or angioedema, life‑threatening skin conditions like Stevens‑Johnson syndrome, blood dyscrasias (e.g., neutropenia), and the emergence of suicidal thoughts or behaviors. Prompt medical attention is required if any of these events occur.

Levetiracetam is contraindicated in patients with known hypersensitivity to levetiracetam or any of the formulation excipients. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric disorders, or those who have experienced serious skin reactions to antiepileptic medications in the past.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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