Product image of Levetiracetam Stragen (Levetiracetam) supplied by GNH India

Levetiracetam Stragen

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Stragen (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Stragen, is an anticonvulsant presented as an intravenous solution for intravenous use. It is indicated for the treatment of partial onset seizures, generalized tonic‑clonic seizures and myoclonic seizures, providing rapid control of seizure activity in hospitalised patients and those requiring acute intervention.

GNH India supplies Levetiracetam Stragen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution across regulatory‑compliant channels.

Manufacturer / TM Owner

Stragen France

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Indications & Clinical Uses

Levetiracetam is used in the management of epileptic seizure disorders, targeting various seizure types.

  • Partial onset seizures: reduces frequency and severity of focal seizures.
  • Generalized tonic‑clonic seizures: helps achieve seizure control in patients with convulsive episodes.
  • Myoclonic seizures: diminishes rapid jerking movements associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates calcium‑dependent exocytosis, stabilising neuronal firing and reducing hyper‑excitability. By limiting the release of excitatory neurotransmitters, the drug helps prevent the synchronous neuronal discharges that underlie epileptic seizures. The precise downstream pathways remain under investigation, but the overall effect is a net decrease in neuronal network synchronisation.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Fatigue: feeling of tiredness or reduced energy.
  • Headache: mild to moderate cranial pain.
  • Irritability: mood changes including agitation or nervousness.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or anaphylaxis requiring immediate medical attention.
  • Mood or behavioral changes: depression, suicidal thoughts, or aggressive behavior.
  • Blood disorders: thrombocytopenia or neutropenia, indicated by abnormal blood counts.

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust dosing or monitor renal function in patients with reduced kidney clearance.
  • Hepatic dysfunction: evaluate liver status as metabolism may be altered.
  • Psychiatric history: monitor for new or worsening mood disturbances.
  • Concomitant CNS depressants: use caution as additive sedation may occur.
  • Pregnancy and lactation: lack of comprehensive data; weigh benefits against potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels, decreasing seizure control.
  • Phenobarbital: can lower levetiracetam concentrations, risking breakthrough seizures.

Moderate Interactions (Monitor Closely)

  • Sedative agents (e.g., benzodiazepines, opioids): may enhance central nervous system depression.
  • Antidepressants (e.g., SSRIs): monitor for increased irritability or mood changes.
  • Immunosuppressants (e.g., cyclosporine): observe for potential alterations in drug levels.

Frequently Asked Questions

Levetiracetam Stragen is an intravenous antiepileptic medication indicated for the acute management of partial onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It is employed in hospital settings where rapid seizure control is required, such as in emergency departments, intensive care units, or during peri‑operative care.

Levetiracetam exerts its effect by binding to the synaptic vesicle protein SV2A, which plays a crucial role in the regulation of neurotransmitter release. This binding modulates calcium‑dependent exocytosis, leading to reduced excitatory neurotransmission and stabilization of neuronal firing, thereby decreasing the likelihood of seizure propagation.

The appropriate dose of Levetiracetam Stragen is individualized by the prescribing clinician based on factors such as the patient’s age, weight, renal function, severity of seizures, and prior response to therapy. No fixed regimen is provided here; the prescriber will set the dosage and infusion rate according to clinical judgment.

Safety data for levetiracetam during pregnancy and lactation are limited, and the product carries an unknown pregnancy category. Clinicians should weigh the potential benefits against possible risks, and consider alternative therapies when appropriate. Breastfeeding mothers should consult their healthcare provider before using the medication.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Levetiracetam Stragen. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team will then respond with pricing, availability, shipping details (including cold‑chain logistics if needed), and any required import documentation.

Levetiracetam offers a favorable pharmacokinetic profile with minimal protein binding and few drug‑enzyme interactions, distinguishing it from older agents such as valproate or carbamazepine, which often require therapeutic drug monitoring and have broader interaction potentials. Its rapid intravenous formulation provides swift seizure control, whereas some alternatives may be limited to oral administration.

Levetiracetam Stragen should be stored refrigerated at 2‑8 °C. The solution must be kept in its original container, protected from light, and should never be frozen or shaken vigorously. If the product must be transported, maintain the cold‑chain conditions throughout to preserve stability.

The medication is supplied as an intravenous solution and is administered by slow infusion into a vein, typically over 15 minutes or as directed by the treating physician. Administration should be performed by qualified healthcare personnel in a setting equipped for intravenous therapy and patient monitoring.

Serious adverse events include severe allergic reactions such as anaphylaxis, significant mood or behavioral changes (including depression, suicidal ideation, or aggression), and hematologic abnormalities like thrombocytopenia or neutropenia. Patients should be monitored closely for these signs, and any concerning symptoms should prompt immediate medical evaluation.

Levetiracetam Stragen is contraindicated in individuals with known hypersensitivity to levetiracetam or any component of the formulation. Caution is also advised for patients with severe renal impairment where dosing adjustments may be required, and for those with a history of serious psychiatric disorders without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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