Product image of Levetiracetam Thame (Levetiracetam) supplied by GNH India

Levetiracetam Thame

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Thame (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Thame, is an anticonvulsant presented as an oral tablet for oral administration. It is used to control partial‑onset, generalized tonic‑clonic, and myoclonic seizures in individuals diagnosed with epilepsy.

GNH India supplies Levetiracetam Thame as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable global distribution.

Manufacturer / TM Owner

Syri Pharma Limited

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Indications & Clinical Uses

Levetiracetam is an anticonvulsant indicated for several seizure disorders.

  • Partial-onset seizures: reduces the frequency of focal seizures in patients with epilepsy.
  • Generalized tonic-clonic seizures: helps prevent convulsive episodes in generalized epilepsy.
  • Myoclonic seizures: controls rapid, brief muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic transmission, decreasing neuronal excitability and stabilizing neuronal firing patterns, which reduces the likelihood of seizure generation and propagation across the brain. The modulation of SV2A leads to reduced calcium‑dependent release of excitatory neurotransmitters, contributing to its antiepileptic activity.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Somnolence
  • Fatigue
  • Headache
  • Irritability
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reactions such as Stevens‑Johnson syndrome
  • Mood changes including depression or suicidal thoughts
  • Severe skin rash
  • Hematologic abnormalities like thrombocytopenia
  • Multi‑organ hypersensitivity reactions
  • Rare hepatic dysfunction

Precautions & Warnings

When prescribing Levetiracetam, clinicians should consider several precautionary measures to ensure safe use.

  • Renal impairment: adjust dose based on creatinine clearance.
  • History of psychiatric disorders: monitor mood and behavior closely.
  • Concomitant CNS depressants: assess additive sedation risk.
  • Pregnancy: evaluate risk‑benefit as data are limited.
  • Elderly patients: start at lower dose and titrate cautiously.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenobarbital: may decrease levetiracetam exposure.
  • Phenytoin: may lower levetiracetam concentrations.

Moderate Interactions (Monitor Closely)

  • Alcohol: may increase central nervous system depression.
  • Other antiepileptic drugs (e.g., valproate): may require dose adjustment.
  • Renal excretion inhibitors (e.g., probenecid): may increase levetiracetam levels.

Frequently Asked Questions

Levetiracetam Thame is prescribed to treat partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures in patients with epilepsy. It helps reduce the frequency and severity of these seizure types by stabilizing neuronal activity.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action decreases neuronal excitability and limits the spread of abnormal electrical activity in the brain, thereby reducing the occurrence of seizures.

The appropriate dose of Levetiracetam Thame is determined by the prescribing clinician based on the patient’s age, renal function, seizure type, and response to therapy. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data for levetiracetam in pregnancy and lactation are limited. Prescribers should weigh the potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant or nursing should discuss treatment options with their healthcare provider.

To request Levetiracetam Thame, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levetiracetam offers a distinct mechanism by targeting SV2A, which differs from sodium‑channel blockers like carbamazepine or GABA‑enhancers such as valproate. It is generally well tolerated, has minimal drug‑enzyme interactions, and can be used as monotherapy or adjunct therapy, making it a versatile option in epilepsy management.

Levetiracetam Thame should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct heat, and ensure the container is tightly closed to maintain product stability.

Levetiracetam Thame is taken orally, usually as a tablet. It can be swallowed whole with water, and may be taken with or without food. The exact administration schedule is set by the prescribing clinician.

Serious risks include severe allergic reactions such as Stevens‑Johnson syndrome, significant mood changes like depression or suicidal thoughts, rare skin rashes, and hematologic abnormalities such as thrombocytopenia. Patients should seek immediate medical attention if they experience any of these symptoms.

Levetiracetam Thame is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is also advised for patients with severe renal impairment, uncontrolled psychiatric conditions, or those taking interacting medications that could markedly reduce its effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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