Product image of Levetiracetam Tillomed (Levetiracetam) supplied by GNH India

Levetiracetam Tillomed

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Tillomed (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Tillomed, is an antiepileptic presented as an intravenous solution for intravenous use. It treats partial‑onset seizures and generalized tonic‑clonic seizures as adjunct therapy in patients with epilepsy.

GNH India supplies Levetiracetam Tillomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Tillomed Pharma Gmbh

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Indications & Clinical Uses

Levetiracetam is an antiepileptic medication used to manage seizure disorders.

  • Partial‑onset seizures: reduces seizure frequency when added to existing therapy.
  • Generalized tonic‑clonic seizures: provides adjunctive control of seizure activity.
  • Adjunct therapy for epilepsy: enhances overall seizure management in patients with refractory epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and decreasing neuronal hyper‑excitability. This interaction stabilises synaptic transmission and limits the propagation of epileptic discharges without significant effects on ion channels or G‑protein pathways.

Side Effects

Levetiracetam may cause a range of adverse reactions.

Common Side Effects

  • Dizziness: mild to moderate sensation of light‑headedness.
  • Fatigue: generalized tiredness or lack of energy.
  • Somnolence: increased sleepiness during the day.
  • Headache: mild to moderate cranial pain.
  • Irritability: mood changes or increased agitation.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Stevens‑Johnson syndrome: rare skin blistering disorder.
  • Blood dyscrasias: neutropenia or thrombocytopenia.
  • Suicidal thoughts: emergence of depressive or suicidal ideation.
  • Severe depression: marked mood disturbances requiring intervention.
  • Respiratory depression: rare but potentially life‑threatening breathing difficulty.

Precautions & Warnings

When using Levetiracetam, consider the following safety measures.

  • Renal impairment: adjust dosing according to renal function.
  • Pregnancy: use only if the potential benefit justifies the risk.
  • Hepatic impairment: monitor liver function tests regularly.
  • Psychiatric symptoms: observe for mood changes, depression, or suicidal thoughts.
  • Concomitant CNS depressants: use with caution due to additive sedation.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Levetiracetam can interact with other medicines; awareness of the level of interaction is important.

Major Interactions (Avoid)

  • Enzyme‑inducing antiepileptics (e.g., carbamazepine, phenytoin): may lower levetiracetam plasma concentrations.
  • Strong CYP inducers (e.g., rifampin): can reduce therapeutic effect.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines, opioids): may increase sedation and respiratory depression.
  • Alcohol: can enhance dizziness and drowsiness.
  • Immunosuppressants (e.g., azathioprine): monitor blood counts for potential additive marrow suppression.

Frequently Asked Questions

Levetiracetam Tillomed is an intravenous antiepileptic indicated as adjunct therapy for partial‑onset seizures and generalized tonic‑clonic seizures in patients with epilepsy, helping to reduce seizure frequency when added to existing treatment regimens.

Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and decreasing neuronal excitability. This stabilises synaptic activity and limits the spread of epileptic discharges without directly affecting ion channels.

The exact dosing regimen for Levetiracetam Tillomed is determined by the prescribing clinician based on the patient’s age, weight, renal function, and clinical response. Healthcare professionals set the appropriate dose and infusion rate.

Safety data for Levetiracetam during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and decisions are made in consultation with a healthcare provider.

To order Levetiracetam Tillomed, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Levetiracetam has a distinct mechanism targeting SV2A and shows minimal protein binding and drug‑metabolism interactions, which can make it easier to combine with other antiepileptics compared with agents that induce hepatic enzymes. Its safety profile is generally favourable, though individual response varies.

Levetiracetam Tillomed should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the solution. Once removed from refrigeration, use within the time frame specified by the manufacturer.

Levetiracetam Tillomed is given by intravenous infusion. The prescribing clinician determines the infusion rate and duration, typically delivering the dose over a period of 15 minutes to several hours, depending on the clinical situation.

Serious risks include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, blood dyscrasias, and emergence of suicidal thoughts or severe depression. Patients should be monitored closely for any signs of these conditions, and treatment should be discontinued if they occur.

Levetiracetam Tillomed is contraindicated in patients with known hypersensitivity to levetiracetam or any of the formulation components. Caution is advised in individuals with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting enzyme‑inducing agents.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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