Product image of Levetiracetam Tillomed (Levetiracetam) supplied by GNH India

Levetiracetam Tillomed

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Tillomed (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Tillomed, is an anticonvulsant presented as an oral formulation for oral use. It is employed to control various seizure types in patients diagnosed with epilepsy. Levetiracetam Tillomed is indicated for partial‑onset, generalized tonic‑clonic and myoclonic seizures and is prescribed by healthcare professionals based on individual therapeutic needs.

GNH India supplies Levetiracetam Tillomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tillomed Laboratories Ltd

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Indications & Clinical Uses

Levetiracetam is an antiepileptic medication that modulates neuronal excitability to prevent seizure activity.

  • Partial‑onset seizures: reduces frequency and severity of focal seizures.
  • Generalized tonic‑clonic seizures: helps achieve seizure control in primary generalized epilepsy.
  • Myoclonic seizures: diminishes rapid, involuntary muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates synaptic vesicle exocytosis, leading to decreased neuronal hyper‑excitability and suppression of abnormal electrical activity that underlies seizure generation.

Side Effects

Levetiracetam is generally well tolerated, but a range of adverse reactions has been reported.

Common Side Effects

  • Dizziness: mild to moderate sensation of light‑headedness.
  • Fatigue: persistent tiredness not related to activity level.
  • Somnolence: increased sleepiness during the day.
  • Headache: mild to moderate cranial pain.
  • Irritability: mood changes including agitation.
  • Nausea: occasional upset stomach.

Serious or Rare Side Effects

  • Severe skin reactions: such as Stevens‑Johnson syndrome.
  • Depression or suicidal thoughts: new or worsening mood disturbances.
  • Blood dyscrasias: including leukopenia or thrombocytopenia.
  • Allergic reactions: rash, angioedema, or anaphylaxis.
  • Multi‑organ involvement: rare cases of hepatic or renal impairment.
  • Respiratory depression: when combined with other CNS depressants.

Precautions & Warnings

When prescribing levetiracetam, clinicians should consider several safety factors.

  • Renal impairment: adjust dose based on creatinine clearance.
  • Hepatic dysfunction: monitor liver function tests periodically.
  • Psychiatric history: observe for mood changes or depressive symptoms.
  • Concomitant CNS depressants: use caution as additive sedation may occur.
  • Pregnancy: risk category unknown; discuss potential benefits and risks with the patient.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Levetiracetam may interact with other medicines, requiring attention to dosage and monitoring.

Major Interactions (Avoid)

  • Carbamazepine: induces metabolism, reducing levetiracetam plasma levels.
  • Phenytoin: increases clearance, potentially decreasing efficacy.
  • Phenobarbital: accelerates elimination, leading to sub‑therapeutic concentrations.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance central nervous system depression.
  • Other antiepileptics: dose adjustments may be needed to maintain seizure control.
  • Renal excretion inhibitors: could raise levetiracetam exposure, requiring monitoring.

Frequently Asked Questions

Levetiracetam Tillomed is an antiepileptic medication indicated for the treatment of partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It is prescribed to reduce the frequency and severity of seizure episodes in patients with epilepsy, helping to improve overall neurological stability.

Levetiracetam exerts its effect by binding to the synaptic vesicle protein SV2A, which plays a crucial role in neurotransmitter release. This binding modulates vesicle exocytosis, leading to a reduction in neuronal hyper‑excitability and the suppression of abnormal electrical discharges that cause seizures.

The dosage of Levetiracetam Tillomed is individualized by the prescribing clinician based on the patient’s age, renal function, seizure type, and response to therapy. The prescriber determines the starting dose and any subsequent titration to achieve optimal seizure control while minimizing adverse effects.

Safety data for levetiracetam in pregnancy and lactation are limited, and the product does not have a definitive pregnancy category. Healthcare providers should weigh the potential benefits against possible risks and discuss these considerations with the patient before initiating therapy.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Compared with older agents such as carbamazepine or valproate, levetiracetam has a simpler pharmacokinetic profile, fewer drug‑enzyme interactions, and a generally favorable tolerability profile. However, individual response varies, and clinicians may choose alternative agents based on specific seizure types, comorbidities, and patient preferences.

Levetiracetam Tillomed should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Levetiracetam Tillomed is administered orally, with or without food, as directed by the prescribing physician. The tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious adverse events, although rare, include severe skin reactions such as Stevens‑Johnson syndrome, significant mood changes including depression or suicidal thoughts, hematologic abnormalities like leukopenia, and allergic reactions that may progress to anaphylaxis. Patients should seek immediate medical attention if any of these symptoms occur.

Levetiracetam is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for patients with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting medications that markedly reduce its plasma concentration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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