Product image of Levetiracetam Zentiva (Levetiracetam) supplied by GNH India

Levetiracetam Zentiva

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Zentiva (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Zentiva, is an anticonvulsant presented as an injectable solution for intravenous use. It is employed as adjunctive therapy for partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients who require additional seizure control.

GNH India supplies Levetiracetam Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug used to manage several seizure types.

  • Partial‑onset seizures: reduces seizure frequency as adjunctive therapy.
  • Generalized tonic‑clonic seizures: provides additional seizure control when combined with other agents.
  • Myoclonic seizures: helps decrease the occurrence of myoclonic episodes as part of combination treatment.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilizing neuronal membranes. This action reduces abnormal neuronal excitability, thereby decreasing the likelihood of seizure propagation across the central nervous system.

Side Effects

Levetiracetam may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Fatigue
  • Somnolence
  • Headache
  • Irritability
  • Nausea

Serious or Rare Side Effects

  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Depression or suicidal thoughts
  • Severe allergic reactions (anaphylaxis)
  • Blood dyscrasias (e.g., neutropenia)
  • Respiratory depression in vulnerable patients

Precautions & Warnings

When using Levetiracetam, consider the following safety measures:

  • Renal impairment: adjust dose based on renal function.
  • Hepatic impairment: monitor liver enzymes and clinical response.
  • Psychiatric disorders: observe for mood changes or depression.
  • Concomitant CNS depressants: may increase sedation; monitor closely.
  • Pregnancy: category unknown; use only if benefit outweighs potential risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levetiracetam has a relatively low interaction profile, but certain drug combinations require attention.

Major Interactions (Avoid)

  • Strong enzyme‑inducing antiepileptics (e.g., carbamazepine, phenobarbital): may lower levetiracetam levels.
  • Live attenuated vaccines: increased risk of infection.

Moderate Interactions (Monitor Closely)

  • Sedative CNS depressants (benzodiazepines, opioids): may enhance sedation.
  • Antidepressants (SSRIs, SNRIs): monitor for mood alterations.
  • Antacids containing aluminum or magnesium: may affect absorption when oral formulations are used.

Frequently Asked Questions

Levetiracetam Zentiva is an injectable antiepileptic medication used as adjunctive therapy for partial‑onset, generalized tonic‑clonic, and myoclonic seizures in patients who need additional seizure control alongside other treatments.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release and stabilizes neuronal firing. This reduces abnormal neuronal excitability and helps prevent the spread of seizure activity in the central nervous system.

The dosage of Levetiracetam Zentiva is determined by the prescribing clinician based on the patient’s age, weight, renal function, and clinical response. The prescriber will set the appropriate dose and administration schedule.

Levetiracetam’s pregnancy category is unknown, and safety data are limited. It should only be used during pregnancy or lactation if the potential benefit justifies the possible risk to the fetus or infant, and under close medical supervision.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed), and import documentation.

Levetiracetam has a distinct mechanism targeting SV2A and generally exhibits fewer drug‑drug interactions than many enzyme‑inducing antiepileptics such as carbamazepine. It is often preferred for patients who require a medication with a low interaction profile and rapid intravenous administration.

Levetiracetam Zentiva should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Follow the manufacturer’s instructions for handling to maintain product stability.

Levetiracetam Zentiva is administered intravenously as an injectable solution. The infusion rate and volume are determined by the healthcare professional, who will follow institutional protocols for IV administration.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, depression or suicidal ideation, anaphylactic reactions, and rare blood disorders. Patients should be monitored closely for any signs of these conditions, and treatment should be discontinued if they occur.

Levetiracetam Zentiva is contraindicated in patients with known hypersensitivity to levetiracetam or any of the formulation components. Caution is also advised for individuals with severe renal impairment where dose adjustment may not be feasible.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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