Product image of Levetiracetam Zentiva (Levetiracetam) supplied by GNH India

Levetiracetam Zentiva

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Zentiva (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Zentiva, is an antiepileptic presented as an oral tablet for oral use. It reduces neuronal excitability and is indicated for the control of partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients diagnosed with epilepsy.

GNH India supplies Levetiracetam Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic drug that acts on seizure activity across several epilepsy syndromes.
  • Partial‑onset seizures: helps achieve reduction in seizure frequency and improves overall seizure control.
  • Generalized tonic‑clonic seizures: contributes to lowering the number of convulsive episodes.
  • Myoclonic seizures: assists in decreasing the occurrence of sudden muscle jerks.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and stabilizing neuronal membranes. This interaction reduces excessive neuronal firing, thereby decreasing the likelihood of seizure propagation across the central nervous system.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Somnolence
  • Fatigue
  • Headache
  • Irritability
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reactions such as Stevens‑Johnson syndrome
  • Mood alterations including depression or suicidal thoughts
  • Severe skin rash
  • Hematologic abnormalities (e.g., leukopenia)
  • Multi‑organ hypersensitivity reactions

Precautions & Warnings

  • Levetiracetam requires careful consideration of patient‑specific factors and safety measures.
  • Renal function: dose may need adjustment in impaired renal function.
  • Psychiatric symptoms: monitor for mood changes, depression, or aggression.
  • Driving: exercise caution if experiencing dizziness or drowsiness.
  • Concomitant CNS depressants: may enhance sedation.
  • Pregnancy and lactation: risk unknown; use only if benefit outweighs potential risk.
  • Store at below 25°C: keep in the original packaging, protect from moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its effectiveness or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenytoin: may decrease levetiracetam exposure.
  • Phenobarbital: may lower levetiracetam concentrations.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive central nervous system depression.
  • Other antiepileptics (e.g., valproate, lamotrigine): monitor seizure control.
  • Renal excretion inhibitors (e.g., probenecid): may increase levetiracetam levels.

Frequently Asked Questions

Levetiracetam Zentiva is prescribed to control seizures in patients with epilepsy. It is indicated for partial‑onset seizures, generalized tonic‑clonic seizures, and myoclonic seizures, helping to reduce the frequency and severity of these events.

Levetiracetam binds to the synaptic vesicle protein SV2A in the brain, which modulates neurotransmitter release. This action stabilizes neuronal firing and diminishes excessive excitability, thereby lowering the likelihood of seizure propagation.

The appropriate dose of Levetiracetam Zentiva is determined by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. Dosage adjustments are made individually and should follow the prescriber’s instructions.

Safety data for levetiracetam in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levetiracetam has a distinct mechanism targeting SV2A, which differs from sodium‑channel blockers like carbamazepine or GABA‑enhancers such as phenobarbital. It is generally well tolerated, has fewer drug‑enzyme interactions, and does not require routine therapeutic drug monitoring, making it a convenient option for many patients.

Store Levetiracetam Zentiva at temperatures below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity.

Levetiracetam Zentiva is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with water and not crushed or chewed unless specifically advised by a healthcare professional.

Serious risks include severe allergic reactions such as Stevens‑Johnson syndrome, significant mood changes like depression or suicidal thoughts, and rare hematologic abnormalities. Patients should seek immediate medical attention if they develop rash, unexplained bruising, or marked changes in mood.

Levetiracetam is contraindicated in individuals with known hypersensitivity to levetiracetam or any of its excipients. Caution is also advised for patients with severe renal impairment, as dose adjustments are required, and for those with a history of psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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