Product image of Levetiracetam Zentiva (Levetiracetam) supplied by GNH India

Levetiracetam Zentiva

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Zentiva (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Zentiva, is an antiepileptic presented as an oral tablet for oral use. It is employed as adjunctive therapy to control partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy. The medication is approved in the European Union and is prescribed by neurologists as part of a comprehensive seizure management plan.

GNH India supplies Levetiracetam Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures reliable delivery and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic drug used to manage seizure disorders by modulating neuronal excitability.
  • Partial‑onset seizures: Reduces frequency of focal seizures when added to existing therapy.
  • Generalized tonic‑clonic seizures: Provides adjunctive control of bilateral convulsive seizures.
  • Myoclonic seizures: Helps decrease rapid, brief muscle jerks as part of combination treatment.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates calcium‑dependent exocytosis, stabilizing synaptic transmission and diminishing neuronal hyperexcitability that underlies epileptic activity. The precise downstream effects are not fully understood, but SV2A binding results in a net anticonvulsant effect without significant interaction with G‑protein‑coupled receptors or ion channels.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Drowsiness: Feeling unusually sleepy or fatigued.
  • Dizziness: Light‑headed sensation, especially when standing quickly.
  • Headache: Mild to moderate cranial pain.
  • Irritability: Mood changes including agitation or aggression.

Serious or Rare Side Effects

  • Severe allergic reaction: Rash, swelling, or difficulty breathing requiring immediate medical attention.
  • Psychiatric disturbances: New or worsening depression, suicidal thoughts, or psychosis.
  • Blood disorders: Unexplained bruising, bleeding, or low blood cell counts.

Precautions & Warnings

  • When prescribing Levetiracetam, clinicians should consider several safety precautions to optimize patient outcomes.
  • Renal impairment: Adjust dose in patients with reduced kidney function.
  • History of psychiatric illness: Monitor for mood changes or suicidal ideation.
  • Concomitant CNS depressants: Use caution as combined sedation may increase.
  • Pregnancy and lactation: Evaluate risk‑benefit ratio before use.
  • Store at ambient temperature: Keep below 25 °C in the original container, protected from moisture.

Avoid Interactions

Levetiracetam can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Carbamazepine: May reduce levetiracetam plasma levels, decreasing effectiveness.
  • Phenobarbital: Can lower levetiracetam concentrations, requiring close monitoring.

Moderate Interactions (Monitor Closely)

  • Alcohol: Combined use may enhance central nervous system depression.
  • Other antiepileptics (e.g., valproate): May require dose adjustments based on clinical response.
  • Oral contraceptives: Levetiracetam may slightly reduce hormonal contraceptive efficacy; consider additional contraceptive methods.

Frequently Asked Questions

Levetiracetam Zentiva is prescribed as an adjunctive antiepileptic medication to control partial‑onset, generalized tonic‑clonic, and myoclonic seizures in patients with epilepsy. It is added to existing therapy when seizure frequency remains inadequate, helping to achieve better overall seizure control.

Levetiracetam exerts its effect by binding to the synaptic vesicle protein SV2A, which regulates neurotransmitter release. This binding modulates calcium‑dependent exocytosis, stabilising synaptic activity and reducing the neuronal hyperexcitability that triggers epileptic seizures.

The dosage of Levetiracetam Zentiva is individualized. A qualified prescriber determines the appropriate dose based on the patient’s age, renal function, seizure type, and response to therapy. Patients should follow the prescribing information provided by their healthcare professional.

Data on levetiracetam use in pregnancy and lactation are limited. Clinicians weigh potential benefits against unknown risks before prescribing to pregnant or nursing women. If treatment is necessary, close monitoring and consultation with a specialist are recommended.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with older agents such as carbamazepine or valproate, levetiracetam has a distinct mechanism (SV2A binding) and a relatively favorable drug‑interaction profile. It is often chosen for patients who need a medication with fewer enzyme‑inducing effects, though individual response and tolerability vary.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. No special refrigeration is required for this oral formulation.

Levetiracetam Zentiva is taken orally, with or without food, as directed by the prescriber. Tablets should be swallowed whole with water. The exact timing and frequency depend on the individualized dosing schedule established by the treating physician.

Serious adverse events include severe allergic reactions (rash, swelling, breathing difficulty), psychiatric disturbances such as new‑onset depression, suicidal thoughts, or psychosis, and hematologic abnormalities like unexplained bruising or low blood counts. Prompt medical attention is required if any of these occur.

Levetiracetam is contraindicated in patients with known hypersensitivity to levetiracetam or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric disorders, or those taking interacting medications that markedly reduce its plasma levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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