Product image of Levetiracetam Zentiva (Levetiracetam) supplied by GNH India

Levetiracetam Zentiva

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Zentiva (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Zentiva, is an anticonvulsant presented as an oral tablet for oral use. It is employed to treat various seizure types in patients diagnosed with epilepsy.

GNH India supplies Levetiracetam Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for regulated markets across Europe, Asia, Africa and the Americas. All shipments are accompanied by full documentation to meet local regulatory requirements.

Manufacturer / TM Owner

Zentiva Portugal, Lda

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Indications & Clinical Uses

  • Levetiracetam is an antiepileptic drug that reduces abnormal neuronal firing in seizure disorders.
  • Partial seizures: decreases frequency of focal onset seizures in patients with epilepsy.
  • Generalized tonic‑clonic seizures: helps control convulsive episodes in patients with generalized epilepsy.
  • Myoclonic seizures: reduces rapid muscle jerks associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds selectively to the synaptic vesicle protein SV2A, a regulator of neurotransmitter release. This interaction modulates calcium‑dependent exocytosis, stabilizing synaptic transmission and lowering neuronal hyper‑excitability. By influencing the vesicle cycle without affecting ion channels directly, the drug dampens the propagation of epileptiform discharges while preserving normal brain activity.

Side Effects

Levetiracetam may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Fatigue: feeling unusually tired or low in energy.
  • Somnolence: increased sleepiness during the day.
  • Headache: mild to moderate cranial pain.
  • Irritability: heightened emotional responsiveness.
  • Nausea: upset stomach, sometimes with mild vomiting.

Serious or Rare Side Effects

  • Severe allergic reactions: including anaphylaxis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: severe skin blistering.
  • Suicidal thoughts or behavior: emergent mood changes.
  • Blood dyscrasias: neutropenia, thrombocytopenia, or anemia.
  • Severe skin rash: widespread erythema or exfoliation.
  • Hepatic failure: signs of liver dysfunction such as jaundice.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Renal impairment: adjust dose in patients with reduced kidney function.
  • Hepatic impairment: monitor liver enzymes in patients with liver disease.
  • Pregnancy: safety not established; weigh benefits against potential risks.
  • Concomitant CNS depressants: monitor for enhanced sedation or respiratory depression.
  • Mood changes: observe for depression, aggression, or suicidal ideation.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light.

Avoid Interactions

Levetiracetam has a relatively low interaction profile, but certain co‑medications require caution.

Major Interactions (Avoid)

  • Carbamazepine: may lower levetiracetam plasma concentrations.
  • Phenytoin: may reduce levetiracetam exposure.
  • Phenobarbital: may decrease levetiracetam levels.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive central nervous system depression.
  • Other antiepileptic drugs (e.g., valproate): may increase risk of adverse effects.
  • Oral contraceptives: may experience reduced efficacy.
  • Antidepressants (e.g., SSRIs): monitor for mood alterations.
  • Antipsychotics: watch for increased sedation.

Frequently Asked Questions

Levetiracetam Zentiva is prescribed to manage epilepsy. It is indicated for partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures, helping to reduce the frequency and severity of seizure episodes in patients diagnosed with these seizure types.

Levetiracetam exerts its effect by binding to the synaptic vesicle protein SV2A. This binding modulates neurotransmitter release, stabilizing synaptic activity and decreasing neuronal hyper‑excitability, which in turn reduces the likelihood of seizure generation and propagation.

The dosage of Levetiracetam Zentiva is individualized. A qualified prescriber determines the appropriate starting dose and any subsequent adjustments based on the patient’s age, renal function, seizure type, and clinical response. Patients should follow the prescribing information provided by their healthcare professional.

Safety data for levetiracetam in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. Clinicians must weigh the potential benefits for seizure control against possible risks to the fetus or infant, and discuss alternatives when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Levetiracetam differs from many traditional antiepileptics such as carbamazepine or valproate because it has a distinct mechanism (SV2A binding) and a relatively low potential for drug‑drug interactions. It is often chosen for its favorable tolerability profile, but individual response and side‑effect considerations guide the final therapeutic choice.

Levetiracetam Zentiva tablets should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct light, and avoid exposure to extreme temperatures to maintain potency throughout its shelf life.

Levetiracetam Zentiva is taken orally. Tablets are swallowed whole with water and may be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare provider and should not crush or chew the tablets unless specifically instructed.

Serious risks include severe allergic reactions such as anaphylaxis, life‑threatening skin conditions like Stevens‑Johnson syndrome, suicidal thoughts or behaviors, blood dyscrasias (e.g., neutropenia), and rare cases of hepatic failure. Immediate medical attention is required if any of these symptoms appear.

Levetiracetam is contraindicated in patients with known hypersensitivity to levetiracetam or any of the tablet’s excipients. Caution is also advised for individuals with severe renal impairment who cannot tolerate dose adjustments, and for pregnant or breastfeeding women when the benefits do not clearly outweigh potential risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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