Product image of Levetiracetam Zentiva (Levetiracetam) supplied by GNH India

Levetiracetam Zentiva

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetam Zentiva (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetam Zentiva, is an anticonvulsant presented as an oral dosage form for oral use. It is prescribed to control various types of epileptic seizures in adults and children.
GNH India supplies Levetiracetam Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Pharma Uk Limited

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Indications & Clinical Uses

Levetiracetam is an antiepileptic drug that modulates neuronal excitability to prevent seizure activity.

  • Partial seizures: decreases frequency of focal onset seizures.
  • Generalized tonic‑clonic seizures: reduces occurrence of bilateral convulsive episodes.
  • Myoclonic seizures: helps control sudden, brief muscle jerks.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release and stabilizes neuronal membranes. This interaction reduces abnormal neuronal firing and diminishes the propagation of seizure activity across the central nervous system.

Side Effects

Levetiracetam may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Fatigue: feeling unusually tired.
  • Somnolence: increased sleepiness.
  • Headache: mild to moderate pain.
  • Irritability: mood changes or agitation.
  • Nausea: upset stomach.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Stevens‑Johnson syndrome: rare skin disorder with blistering.
  • Blood dyscrasias: abnormal blood counts.
  • Suicidal thoughts: new or worsening depression.
  • Severe skin rash: widespread redness or peeling.
  • Depression: persistent low mood.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Renal impairment: dose adjustment may be required based on kidney function.
  • Hepatic impairment: monitor liver enzymes and adjust if necessary.
  • Concomitant CNS depressants: may increase sedation, use caution.
  • Pregnancy: risk unknown; discuss benefits and risks with a healthcare professional.
  • Driving or operating machinery: dizziness may impair performance; exercise caution.
  • Store below 25°C: keep in the original packaging, protect from moisture.

Avoid Interactions

Levetiracetam can interact with several medicines, influencing its effectiveness or safety.

Major Interactions (Avoid)

  • Carbamazepine: may lower levetiracetam plasma levels.
  • Phenytoin: can reduce levetiracetam concentration.
  • Phenobarbital: may decrease levetiracetam exposure.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive CNS depression, increase drowsiness.
  • Other antiepileptics: potential for enhanced seizure control or toxicity.
  • Hormonal contraceptives: possible reduction in contraceptive efficacy.

Frequently Asked Questions

Levetiracetam Zentiva is prescribed to treat partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures. It helps reduce the frequency and severity of these epileptic events in both adult and pediatric patients when used under medical supervision.

Levetiracetam binds to the synaptic vesicle protein SV2A, which regulates neurotransmitter release. This binding stabilizes neuronal membranes and diminishes excessive neuronal firing, thereby lowering the likelihood of seizure initiation and spread throughout the brain.

The appropriate dose of Levetiracetam Zentiva is determined individually by a prescriber based on the patient’s age, weight, renal function, and seizure type. Healthcare professionals tailor the regimen to achieve optimal seizure control while minimizing side effects.

Safety data for levetiracetam in pregnancy and lactation are limited. The prescriber should evaluate the potential benefits against possible risks before prescribing to pregnant or nursing women, and discuss alternative options if concerns arise.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Levetiracetam offers a distinct mechanism by targeting SV2A, which differs from sodium‑channel blockers like carbamazepine or GABA‑enhancers such as valproate. It is generally well tolerated, has fewer drug‑enzyme interactions, and can be used as monotherapy or adjunctive therapy depending on the clinical scenario.

Store Levetiracetam Zentiva at temperatures below 25 °C, in its original packaging, and protect it from moisture and direct sunlight. Maintaining these conditions helps preserve the product’s stability and potency throughout its shelf life.

Levetiracetam Zentiva is taken orally, usually with or without food, as directed by the prescribing clinician. Tablets should be swallowed whole with water; patients should follow the exact schedule and dosage prescribed to maintain consistent blood levels.

Serious risks include severe allergic reactions, skin conditions such as Stevens‑Johnson syndrome, blood dyscrasias, and emerging suicidal thoughts or depression. Patients should seek immediate medical attention if they notice rash, swelling, mood changes, or any signs of a severe reaction.

Individuals with known hypersensitivity to levetiracetam or any of its excipients should avoid the product. Patients with severe renal impairment may require alternative therapy or careful dose adjustment, and it should be used only under medical guidance in such cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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