Product image of Levetiracetamum Eugia (Levetiracetam) supplied by GNH India

Levetiracetamum Eugia

Active Ingredient:
Levetiracetam
Origin:
EU

Levetiracetamum Eugia (Levetiracetam)

Levetiracetam, the active ingredient in Levetiracetamum Eugia, is an anticonvulsant presented as an injection solution for intravenous use. It is used as adjunctive therapy for partial‑onset, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy.

GNH India supplies Levetiracetamum Eugia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Eugia Pharma (Malta) Ltd

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Indications & Clinical Uses

Levetiracetam is an anticonvulsant indicated for adjunctive treatment of several seizure types.

  • Partial‑onset seizures: reduces seizure frequency when added to existing antiepileptic therapy.
  • Generalized tonic‑clonic seizures: provides additional seizure control in patients with refractory episodes.
  • Myoclonic seizures: helps decrease myoclonic seizure episodes as part of combination therapy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, modulating neurotransmitter release and decreasing neuronal excitability. This interaction stabilises synaptic transmission and reduces the likelihood of seizure propagation without directly affecting ion channels or GABA receptors.

Side Effects

Levetiracetam may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Fatigue: feeling unusually tired or weak.
  • Headache: mild to moderate head pain.
  • Irritability: increased agitation or mood changes.

Serious or Rare Side Effects

  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Mood or behavior changes: depression, suicidal thoughts, or aggression.
  • Hematologic abnormalities: low blood cell counts.
  • Stevens‑Johnson syndrome: severe skin blistering.

Precautions & Warnings

When prescribing levetiracetam, clinicians should consider several safety aspects.

  • Renal function: adjust use in patients with impaired renal clearance.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Psychiatric history: observe for mood alterations.
  • Discontinue gradually: avoid abrupt cessation to reduce seizure recurrence.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Levetiracetam can interact with other medicines, requiring attention to potential changes in efficacy or safety.

Major Interactions (Avoid)

  • Carbamazepine: may reduce levetiracetam plasma levels.
  • Phenobarbital: may decrease levetiracetam efficacy.
  • Rifampicin: may increase clearance, lowering therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Valproic acid: may increase risk of central nervous system depression.
  • Sedative antihistamines: may enhance dizziness or fatigue.
  • Alcohol: may potentiate central nervous system effects.

Frequently Asked Questions

Levetiracetamum Eugia is an intravenous formulation of levetiracetam used as adjunctive therapy for patients with epilepsy who experience partial‑onset, generalized tonic‑clonic, or myoclonic seizures that are not adequately controlled by their current antiepileptic regimen.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilises neuronal firing and reduces hyper‑excitability, thereby decreasing the likelihood of seizure generation and spread.

The appropriate dose is determined by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. Dosing is individualized and should follow the prescriber’s instructions and local guidelines.

Safety data for levetiracetam during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Levetiracetam has a distinct mechanism (SV2A modulation) and a relatively favourable interaction profile compared with many enzyme‑inducing agents such as carbamazepine or phenytoin. It is often chosen for patients who need a medication with minimal hepatic metabolism and fewer drug‑drug interactions, though individual response and tolerability vary.

The product should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use and discard any solution that appears discoloured or contains particles.

Levetiracetamum Eugia is supplied as a sterile injection solution for intravenous infusion. It should be administered by a qualified healthcare professional, typically diluted in compatible IV fluids and infused over a period recommended by the prescriber.

Serious adverse events include severe allergic reactions (e.g., anaphylaxis or Stevens‑Johnson syndrome), marked mood or behavior changes such as depression or suicidal thoughts, and hematologic abnormalities like low blood cell counts. Prompt medical attention is required if any of these occur.

Patients with a known hypersensitivity to levetiracetam or any component of the injection solution should avoid its use. Caution is also advised for individuals with severe renal impairment, as dose adjustment may be necessary, and for those with a history of serious psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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