Product image of Levezil (Levetiracetam) supplied by GNH India

Levezil

Active Ingredient:
Levetiracetam
Origin:
EU

Levezil (Levetiracetam)

Levetiracetam, the active ingredient in Levezil, is an anticonvulsant presented as an oral tablet for oral use. It is prescribed to manage partial, generalized tonic‑clonic and myoclonic seizures in patients with epilepsy, offering a broad spectrum of seizure control across adult and pediatric populations.

GNH India supplies Levezil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to EU quality standards and providing reliable global logistics for regulated medicines, with dedicated regulatory support and on‑time delivery.

Manufacturer / TM Owner

Ardez Pharma

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Indications & Clinical Uses

  • Levezil is used to treat seizure disorders within the epileptic disease spectrum.
  • Partial seizures: reduces frequency of focal onset seizures, improving seizure control.
  • Generalized tonic‑clonic seizures: helps prevent convulsive episodes in patients with generalized epilepsy.
  • Myoclonic seizures: diminishes rapid jerking movements associated with myoclonic epilepsy.

How It Works

  • Levetiracetam binds to the synaptic vesicle protein SV2A, a key regulator of neurotransmitter release. This interaction modulates calcium‑dependent vesicle exocytosis, stabilizing neuronal membranes and decreasing hyper‑excitability. By reducing the release of excitatory neurotransmitters, the drug lowers the likelihood of synchronized neuronal firing that underlies seizure generation. The precise binding site remains under investigation, but the overall effect is a net reduction in neuronal network synchrony without significant interaction with G‑protein coupled receptors or ion channels.

Side Effects

Levezil may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Dizziness
  • Somnolence
  • Fatigue
  • Headache
  • Irritability
  • Nausea

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis)
  • Stevens‑Johnson syndrome or other severe skin reactions
  • Blood dyscrasias such as agranulocytosis
  • Suicidal ideation or severe depression
  • Rash with mucosal involvement

Precautions & Warnings

  • When prescribing Levezil, clinicians should consider several safety measures.
  • Dose adjustment: required in patients with renal impairment according to creatinine clearance.
  • Pregnancy: safety not established; use only if benefits outweigh risks.
  • Concomitant CNS depressants: monitor for additive sedation.
  • Behavioral changes: observe for mood swings, aggression, or depression.
  • Avoid abrupt discontinuation: taper under medical supervision to reduce seizure recurrence.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Levezil can interact with other medicines, necessitating careful review.

Major Interactions (Avoid)

  • Carbamazepine: induces metabolism, reducing levetiracetam levels.
  • Phenobarbital: enzyme induction may lower efficacy.
  • Phenytoin: may decrease plasma concentrations of levetiracetam.

Moderate Interactions (Monitor Closely)

  • Alcohol: additive CNS depression.
  • Other antiepileptics (e.g., valproate): may require dose adjustment.
  • Renal excretion inhibitors (e.g., probenecid): may increase levetiracetam exposure.

Frequently Asked Questions

Levezil contains levetiracetam and is prescribed for the treatment of epilepsy. It is indicated for partial (focal) seizures, generalized tonic‑clonic seizures, and myoclonic seizures, helping to reduce seizure frequency and improve overall seizure control.

Levetiracetam binds to the synaptic vesicle protein SV2A, which modulates neurotransmitter release. This action stabilises neuronal membranes, reduces excitatory neurotransmission, and lowers the likelihood of the synchronized neuronal firing that triggers seizures.

The dose of Levezil is individualized by the prescribing clinician based on the patient’s age, weight, renal function, and seizure type. The prescriber determines the starting dose and any subsequent titration to achieve optimal seizure control.

Safety data for levetiracetam in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order Levezil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Levezil (levetiracetam) offers a favourable safety profile and minimal drug‑enzyme interactions compared with many older antiepileptics such as carbamazepine or phenytoin. It is often chosen for patients who require a medication with fewer metabolic concerns, though individual response varies.

Levezil tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Levezil is taken orally as a tablet. It should be swallowed whole with a glass of water and can be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include severe allergic reactions such as anaphylaxis, skin conditions like Stevens‑Johnson syndrome, blood dyscrasias, and neuropsychiatric events such as suicidal thoughts, severe depression, or aggressive behaviour. Prompt medical attention is required if any of these occur.

Levezil should be avoided in individuals with known hypersensitivity to levetiracetam or any of its excipients. Patients with severe renal impairment must have dose adjustments; without appropriate modification, the drug may accumulate and increase toxicity risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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