Product image of Leviogel (Diclofenac Sodium) supplied by GNH India

Leviogel

Active Ingredient:
Diclofenac Sodium
Origin:
EU

Leviogel (Diclofenac Sodium)

Diclofenac sodium, the active ingredient in Leviogel, is a nonsteroidal anti‑inflammatory drug (NSAID) formulated as a topical gel for external application. It is used to alleviate mild to moderate pain and to diminish inflammation associated with musculoskeletal disorders such as sprains, strains and osteoarthritis.

GNH India supplies Leviogel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets.

Manufacturer / TM Owner

Laboratorio Farmaceutico S.I.T. S.R.L.

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Indications & Clinical Uses

Leviogel (diclofenac sodium) is applied topically to target inflammatory pathways in musculoskeletal conditions.

  • Osteoarthritis: reduces joint pain and swelling.
  • Rheumatoid arthritis: alleviates joint inflammation and discomfort.
  • Acute sprains and strains: provides localized pain relief and reduces swelling.

How It Works

  • Diclofenac sodium works by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis leads to reduced inflammation, pain, and swelling at the site of topical application.

Side Effects

Topical diclofenac may cause local skin reactions and, in rare cases, systemic adverse events.

Common Side Effects

  • Skin irritation: mild redness or burning at the application site.
  • Itching: localized pruritus.
  • Dryness: transient dry skin.
  • Rash: mild erythematous rash.

Serious or Rare Side Effects

  • Allergic reactions: angioedema or anaphylaxis.
  • Severe skin disorders: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic effects: hepatic dysfunction, renal impairment, or cardiovascular events.
  • Blood disorders: thrombocytopenia or anemia.
  • Gastrointestinal bleeding: rare but possible with extensive use.

Precautions & Warnings

When using Leviogel, consider the following safety measures.

  • Assess skin integrity: avoid application on broken, infected, or irritated skin.
  • Limit treated area: do not exceed 10% of total body surface area per day.
  • Avoid occlusion: do not cover the gel with airtight dressings unless directed by a clinician.
  • Monitor systemic absorption: use caution in patients with cardiovascular or renal disease.
  • Pregnancy and lactation: only use if the potential benefit justifies the potential risk.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Diclofenac sodium can interact with several systemic medications; awareness helps minimize risk.

Major Interactions (Avoid)

  • Concurrent systemic NSAIDs: increased risk of gastrointestinal bleeding.
  • Anticoagulants (e.g., warfarin, DOACs): heightened bleeding tendency.
  • Selective COX‑2 inhibitors: additive cardiovascular risk.

Moderate Interactions (Monitor Closely)

  • Diuretics: may reduce renal clearance of NSAIDs.
  • ACE inhibitors or ARBs: potential for renal impairment.
  • Lithium: NSAIDs can raise lithium serum concentrations.

Frequently Asked Questions

Leviogel is a topical gel containing diclofenac sodium that is used to relieve mild to moderate pain and reduce inflammation in musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, and acute sprains or strains.

Diclofenac sodium inhibits the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the production of prostaglandins that mediate inflammation and pain. This action reduces swelling and provides analgesic effects at the site where the gel is applied.

The appropriate amount of Leviogel is determined by the prescribing healthcare professional based on the patient’s condition, the size of the area to be treated, and local regulatory guidance. Patients should follow the prescriber’s instructions exactly.

Safety of topical diclofenac during pregnancy or lactation has not been definitively established. It should only be used if the potential benefit outweighs any possible risk, and the decision must be made by a qualified healthcare provider.

To order Leviogel, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Leviogel contains diclofenac sodium, a well‑studied NSAID, and offers comparable anti‑inflammatory and analgesic efficacy to other topical diclofenac formulations. Its gel base may provide a different feel or absorption profile, but clinical outcomes are generally similar across approved diclofenac gels.

Leviogel should be stored at room temperature, below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing the product.

The gel is applied to clean, dry skin on the affected area. A thin layer is spread and gently massaged until absorbed. Hands should be washed after application, and the treated area should not be covered with airtight dressings unless directed by a clinician.

Serious risks, though rare, include severe allergic reactions such as angioedema or anaphylaxis, serious skin disorders like Stevens‑Johnson syndrome, and systemic effects such as liver or kidney impairment, especially with extensive use or in vulnerable patients.

Leviogel should not be used on patients with known hypersensitivity to diclofenac or other NSAIDs, on broken or infected skin, or in individuals with a history of severe cardiovascular, hepatic, or renal disease unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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