Product image of Leviosa (Dexamethasone, Levofloxacin) supplied by GNH India

Leviosa

Active Ingredient:
Dexamethasone, Levofloxacin
Origin:
EU

Leviosa (Dexamethasone, Levofloxacin)

Dexamethasone and Levofloxacin, the active ingredients in Leviosa, are a corticosteroid and a fluoroquinolone antibiotic presented as an ophthalmic solution for ocular use. They reduce inflammation and inhibit bacterial growth, making the product suitable for treating bacterial conjunctivitis, post‑operative ocular inflammation, and mixed bacterial‑inflammatory eye conditions in adult patients.

GNH India supplies Leviosa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU pharmacopeial standards and is distributed under strict quality‑assured conditions.

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Indications & Clinical Uses

  • Leviosa acts on ocular inflammatory and bacterial pathways to manage mixed eye conditions.
  • Bacterial conjunctivitis: reduces bacterial load and associated inflammation.
  • Post‑operative ocular inflammation: controls inflammation after eye surgery while preventing infection.
  • Mixed bacterial‑inflammatory eye conditions: provides combined anti‑inflammatory and antibacterial therapy in a single formulation.

How It Works

  • Dexamethasone binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress pro‑inflammatory cytokines, chemokines and adhesion molecules, thereby reducing ocular inflammation. Levofloxacin penetrates bacterial cells and inhibits DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, leading to bactericidal activity against susceptible Gram‑negative and Gram‑positive ocular pathogens. The combined formulation provides simultaneous anti‑inflammatory and antibacterial effects, facilitating faster resolution of mixed infections.

Side Effects

Leviosa may cause ocular and systemic adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Transient burning or stinging sensation upon instillation.
  • Temporary blurred vision.
  • Mild conjunctival hyperemia.
  • Increased intra‑ocular pressure (mild).
  • Headache.
  • Allergic conjunctivitis (mild).

Serious or Rare Side Effects

  • Severe allergic reaction or anaphylaxis.
  • Corneal ulceration or perforation.
  • Significant rise in intra‑ocular pressure leading to glaucoma.
  • Development of resistant bacterial strains.
  • Cataract formation with prolonged use.
  • Systemic corticosteroid effects such as hyperglycemia.

Precautions & Warnings

  • When prescribing Leviosa, clinicians should consider several precautionary measures to ensure safe use.
  • Assess infection type: confirm bacterial etiology before use.
  • Monitor intra‑ocular pressure: especially in steroid‑responsive patients.
  • Avoid in viral or fungal eye infections: may worsen condition.
  • Use with caution in patients with known hypersensitivity to corticosteroids or fluoroquinolones.
  • Pregnancy and lactation: evaluate risk‑benefit as safety data are limited.
  • Store below 25°C: keep in original container, protect from light and moisture.

Avoid Interactions

Leviosa can interact with other ophthalmic or systemic agents, influencing efficacy or safety.

Major Interactions (Avoid)

  • Concurrent use of other potent topical corticosteroids: may increase risk of ocular hypertension and cataract.
  • Systemic fluoroquinolones with QT‑prolonging drugs: may potentiate cardiac arrhythmia risk.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory eye drops: may reduce anti‑inflammatory effect.
  • Anticholinergic eye medications: may affect pupil size and intra‑ocular pressure.

Frequently Asked Questions

Leviosa is an ophthalmic solution that combines a corticosteroid and a fluoroquinolone antibiotic. It is indicated for the treatment of bacterial conjunctivitis, post‑operative ocular inflammation, and mixed bacterial‑inflammatory eye conditions where both anti‑inflammatory and antibacterial actions are required.

Dexamethasone acts on glucocorticoid receptors to suppress inflammatory mediators, reducing swelling and redness in the eye. Levofloxacin penetrates bacterial cells and blocks DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, resulting in bactericidal activity. Together they provide simultaneous control of inflammation and infection.

The dosing regimen for Leviosa is determined by the prescribing ophthalmologist based on the severity of the condition, patient age, and response to therapy. The prescriber will specify the number of drops, frequency, and duration of treatment.

Safety data for Leviosa in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative therapies when appropriate. If treatment is deemed necessary, it should be used under close medical supervision.

To request Leviosa, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements) and required import documentation.

Compared with separate dexamethasone eye drops and fluoroquinolone antibiotics, Leviosa offers the convenience of a single formulation that delivers both anti‑inflammatory and antibacterial effects. This can improve patient adherence and reduce the need for multiple bottles, while maintaining comparable efficacy and safety profiles to the individual agents.

Leviosa should be stored below 25 °C in its original container, protected from light and moisture. Do not freeze the product. Keep the vial tightly closed when not in use and discard any solution that appears discolored or contaminated.

Leviosa is applied topically to the eye as directed by the prescriber. Typically, one or more drops are placed into the affected eye(s) at the prescribed interval. Patients should wash their hands before and after administration and avoid touching the tip of the bottle to the ocular surface.

Serious risks include severe allergic reactions (anaphylaxis), significant elevation of intra‑ocular pressure that may lead to glaucoma, corneal ulceration, development of resistant bacterial strains, and, with prolonged use, cataract formation. Patients should be monitored regularly for these events, especially if therapy extends beyond the recommended duration.

Leviosa is contraindicated in patients with known hypersensitivity to dexamethasone, levofloxacin, other corticosteroids, or fluoroquinolones. It should also be avoided in viral, fungal, or amoebic eye infections, as corticosteroids can exacerbate these conditions. Caution is advised in individuals with uncontrolled glaucoma or a history of steroid‑responsive intra‑ocular pressure elevation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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