Product image of Levmentin Adultes (Amoxicillin, Clavulanic Acid) supplied by GNH India

Levmentin Adultes

Active Ingredient:
Amoxicillin, Clavulanic Acid
Origin:
EU

Levmentin Adultes (Amoxicillin, Clavulanic Acid)

Amoxicillin and Clavulanic Acid, the active ingredient in Levmentin Adultes, is a beta‑lactam antibiotic presented as a combination formulation for intravenous use. It treats a range of bacterial infections in adult patients, including respiratory, skin, intra‑abdominal and urinary tract infections.

GNH India supplies Levmentin Adultes as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company adheres to EU quality standards and provides reliable logistics for bulk and unit‑dose deliveries. Clients benefit from regulatory support, temperature‑controlled shipping where required, and transparent documentation throughout the supply chain.

Manufacturer / TM Owner

Laboratoires Delbert

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Indications & Clinical Uses

Levmentin Adultes, a beta‑lactam antibacterial, is indicated for several common bacterial infection categories.

  • Respiratory tract infections: effective treatment of community‑acquired pneumonia and related bacterial respiratory diseases.
  • Skin and soft tissue infections: resolves cellulitis, abscesses and other bacterial skin conditions.
  • Intra‑abdominal infections: used for complicated intra‑abdominal infections such as peritonitis.
  • Urinary tract infections: treats acute uncomplicated and complicated urinary tract infections caused by susceptible organisms.

How It Works

  • Amoxicillin binds to penicillin‑binding proteins, inhibiting the synthesis of bacterial cell wall peptidoglycan, which leads to cell lysis. Clavulanic acid acts as a suicide inhibitor of beta‑lactamase enzymes, protecting amoxicillin from enzymatic degradation and extending its antibacterial spectrum against beta‑lactamase‑producing organisms.

Side Effects

Adverse reactions may occur with any intravenous antibiotic and should be monitored.

Common Side Effects

  • Nausea or vomiting.
  • Diarrhea, which may be mild to moderate.
  • Rash or mild skin erythema.
  • Injection‑site phlebitis or discomfort.
  • Elevated liver enzymes (transaminases).
  • Headache.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reactions.
  • Acute hepatic injury or jaundice.
  • Clostridioides difficile‑associated colitis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Neutropenia or other blood dyscrasias.
  • Serum sickness‑like reactions.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor appropriately.

  • Renal function: adjust dosing in patients with impaired renal clearance.
  • Hepatic function: monitor liver enzymes during prolonged treatment.
  • Allergy: avoid in individuals with known penicillin or beta‑lactam hypersensitivity.
  • Concomitant antibiotics: assess for additive toxicity when combined with other beta‑lactams.
  • Pregnancy and lactation: evaluate risk‑benefit; limited safety data are available.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Levmentin Adultes can interact with several medicines; clinical judgment is required.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase INR and bleeding risk.
  • Allopurinol: heightened risk of severe skin rash.
  • Methotrexate: reduced clearance leading to potential toxicity.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in efficacy, advise backup method.
  • Probenecid: may increase plasma concentrations of amoxicillin.
  • Loop diuretics (e.g., furosemide): potential for increased nephrotoxicity.

Frequently Asked Questions

Levmentin Adultes is a combination of amoxicillin and clavulanic acid administered intravenously to treat a variety of bacterial infections in adults, including community‑acquired pneumonia, skin and soft‑tissue infections, complicated intra‑abdominal infections, and urinary tract infections caused by susceptible organisms.

Amoxicillin interferes with bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, causing cell lysis. Clavulanic acid inhibits beta‑lactamase enzymes produced by resistant bacteria, protecting amoxicillin from degradation and extending its activity against beta‑lactamase‑producing strains.

The dosage of Levmentin Adultes is determined by the prescribing clinician based on the type and severity of infection, patient weight, renal function, and local antimicrobial guidelines. No fixed regimen is provided here; the prescriber sets the appropriate dose and infusion rate.

Safety data for intravenous amoxicillin/clavulanic acid in pregnancy and lactation are limited. Clinicians should weigh the potential benefits against possible risks and consider alternative therapies when appropriate. If used, close monitoring of the mother and fetus or infant is advised.

To place an order, submit an enquiry on the Levmentin Adultes product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Levmentin Adultes combines a broad‑spectrum penicillin (amoxicillin) with a beta‑lactamase inhibitor (clavulanic acid), offering activity against many beta‑lactamase‑producing organisms that plain amoxicillin cannot cover. Compared with cephalosporins, it provides a similar spectrum for Gram‑positive and some Gram‑negative pathogens but may be preferred when beta‑lactamase resistance is suspected.

The product should be stored at 2‑8 °C, kept refrigerated, protected from light, and not frozen. Once reconstituted, use according to the manufacturer’s stability guidelines and discard any unused portion after the recommended time to maintain sterility.

Levmentin Adultes is given by intravenous infusion. The prepared solution is administered over a period defined by the prescriber, typically ranging from 30 minutes to several hours, depending on the infection severity and patient tolerance.

Serious adverse events include anaphylaxis or severe allergic reactions, acute hepatic injury, Clostridioides difficile‑associated colitis, and rare skin disorders such as Stevens‑Johnson syndrome. Patients should be monitored for signs of rash, jaundice, gastrointestinal upset, or respiratory distress, and treatment should be stopped if severe reactions occur.

Levmentin Adultes is contraindicated in individuals with a known hypersensitivity to amoxicillin, clavulanic acid, or any other beta‑lactam antibiotics. Caution is also advised for patients with severe hepatic impairment or a history of severe allergic reactions to related drugs.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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