Product image of Levobens (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Levobens

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Levobens (Benserazide Hydrochloride, Levodopa)

Levodopa/Benserazide, the active ingredient in Levobens, is a dopamine precursor presented as a tablet oral formulation for oral use. It works by delivering levodopa, which is converted to dopamine in the brain, while benserazide blocks its peripheral breakdown, thereby treating the motor symptoms of Parkinson's disease in adult patients.

GNH India supplies Levobens as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity across global markets through robust distribution networks.

Manufacturer / TM Owner

Teva Gmbh

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Indications & Clinical Uses

  • Levobens, a combination of levodopa and benserazide, is used in the management of Parkinsonian disorders.
  • Parkinson's disease: improves motor symptoms such as tremor, rigidity, and bradykinesia.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine by aromatic L‑amino‑acid decarboxylase within central neurons. Benserazide, a peripheral aromatic L‑amino‑acid decarboxylase inhibitor that does not cross the blood‑brain barrier, prevents peripheral conversion of levodopa, increasing the amount of levodopa available for central conversion and enhancing dopaminergic stimulation of striatal receptors.

Side Effects

Levodopa/benserazide may cause a range of adverse reactions, which are grouped by frequency.

Common Side Effects

  • Nausea: upset stomach often occurring after dose initiation.
  • Orthostatic hypotension: dizziness upon standing.
  • Dyskinesia: involuntary movements with chronic use.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome: life‑threatening reaction with fever and rigidity.
  • Severe psychiatric disturbances: hallucinations or psychosis.
  • Cardiac arrhythmias: irregular heart rhythm requiring monitoring.

Precautions & Warnings

When prescribing Levobens, several safety considerations should be observed.

  • Renal or hepatic impairment: adjust monitoring as metabolism may be affected.
  • Cardiovascular disease: monitor blood pressure due to orthostatic effects.
  • Psychiatric history: watch for hallucinations or confusion.
  • Concomitant MAO‑B inhibitors: avoid due to risk of hypertensive crisis.
  • Pregnancy and lactation: use only if benefit outweighs risk, as safety data are limited.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Levobens can interact with several medicines; interactions are classified by clinical significance.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: may cause hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): reduce levodopa efficacy.
  • High‑dose pyridoxine (vitamin B6): increases peripheral levodopa metabolism.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: additive effect on blood pressure.
  • SSRIs or SNRIs: may increase risk of serotonin syndrome.
  • Iron or calcium supplements: decrease levodopa absorption if taken simultaneously.

Frequently Asked Questions

Levobens is a prescription oral tablet that combines levodopa and benserazide. It is used to manage the motor symptoms of Parkinson's disease, such as tremor, rigidity, and slowness of movement, by increasing dopamine levels in the brain.

Levodopa is a precursor that crosses the blood‑brain barrier and is converted into dopamine, the neurotransmitter deficient in Parkinson's disease. Benserazide inhibits the peripheral conversion of levodopa, ensuring more of the drug reaches the brain where it can be transformed into dopamine.

The dosage of Levobens is individualized by the prescribing clinician based on the patient’s disease stage, response, and tolerability. The prescriber determines the appropriate strength, frequency, and titration schedule for each patient.

Safety data for levodopa/benserazide in pregnancy and lactation are limited. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Levobens, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Levobens combines levodopa with a peripheral decarboxylase inhibitor, offering higher central availability of levodopa compared with levodopa alone. This can provide more consistent symptom control than some dopamine agonists, though individual response and side‑effect profiles vary among patients.

Levobens tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Keep the container tightly closed, protect from moisture and light, and discard any tablets that appear discoloured or damaged.

Levobens is taken orally, usually with a glass of water. It can be taken with or without food, but a consistent routine helps maintain stable drug levels. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include neuroleptic malignant syndrome, severe psychiatric disturbances such as hallucinations or psychosis, and cardiac arrhythmias. Any sudden fever, rigidity, confusion, or irregular heartbeat should prompt immediate medical attention.

Levobens is contraindicated in patients with known hypersensitivity to levodopa, benserazide, or any excipients, and in those taking non‑selective monoamine oxidase inhibitors. Caution is also advised for individuals with uncontrolled cardiovascular disease, severe hepatic or renal impairment, and certain psychiatric conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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