Product image of Levobupivacaina Altan (Levobupivacaine) supplied by GNH India

Levobupivacaina Altan

Active Ingredient:
Levobupivacaine
Origin:
EU

Levobupivacaina Altan (Levobupivacaine)

Levobupivacaine, the active ingredient in Levobupivacaina Altan, is a local anesthetic presented as a solution for epidural, infiltration, intrathecal and peripheral use. It provides surgical anesthesia and analgesia for patients undergoing surgery, postoperative pain management, and labor analgesia.

GNH India supplies Levobupivacaina Altan as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Altan Pharmaceuticals S.A.

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Indications & Clinical Uses

  • Levobupivacaine is employed in regional anesthesia to manage pain associated with surgical and obstetric procedures.
  • Surgical anesthesia: provides intra‑operative anesthesia for a variety of surgeries.
  • Post‑operative analgesia: extends pain relief during the recovery period after surgery.
  • Labor analgesia: offers effective pain control during childbirth.

How It Works

  • Levobupivacaine blocks voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel and preventing the initiation and propagation of nerve impulses. This reversible inhibition reduces the transmission of pain signals, producing localized loss of sensation without affecting consciousness.

Side Effects

Adverse reactions may occur following administration of levobupivacaine.

Common Side Effects

  • Hypotension
  • Bradycardia
  • Dizziness
  • Nausea
  • Metallic taste
  • Headache

Serious or Rare Side Effects

  • Seizures
  • Cardiac arrhythmia
  • Respiratory depression
  • Prolonged motor block
  • Allergic reactions (e.g., rash, angioedema)
  • Systemic toxicity with CNS and cardiovascular manifestations

Precautions & Warnings

  • Levobupivacaina Altan should be used with careful clinical monitoring.
  • Dose individualization: dose should be determined by the prescribing clinician based on patient factors and procedure.
  • Cardiovascular monitoring: observe heart rate and blood pressure during and after administration.
  • CNS monitoring: watch for early signs of toxicity such as tinnitus, metallic taste or visual disturbances.
  • Pregnancy considerations: use only when the expected benefit justifies potential risk to the fetus.
  • Drug interactions: avoid concurrent use with other local anesthetics or agents that may increase cardiotoxicity.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Levobupivacaina Altan may interact with other medications, altering its safety profile.

Major Interactions (Avoid)

  • Concurrent use with other amide local anesthetics: increased risk of systemic toxicity.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): may raise plasma concentrations.
  • Beta‑adrenergic blockers: can exacerbate bradycardia.
  • Drugs that lower seizure threshold (e.g., tramadol): heightened seizure risk.
  • High‑dose epinephrine co‑administration: may affect absorption and cardiovascular response.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers: monitor cardiovascular status.
  • CNS depressants (e.g., benzodiazepines): enhanced sedation possible.
  • Diuretics: monitor electrolyte balance.

Frequently Asked Questions

Levobupivacaina Altan contains levobupivacaine, a local anesthetic that is used to provide surgical anesthesia, postoperative analgesia, and labor analgesia. It is administered by regional techniques such as epidural, infiltration, intrathecal, or peripheral nerve blocks to achieve targeted pain control.

Levobupivacaine works by reversibly blocking voltage‑gated sodium channels on nerve membranes. This action stabilises the neuronal membrane in its inactive state, preventing the initiation and propagation of action potentials, which stops the transmission of pain signals from the site of injection to the central nervous system.

The dose of Levobupivacaina Altan is individualized and must be determined by the prescribing clinician. Dosing depends on factors such as the type of procedure, patient age, weight, comorbidities, and the specific route of administration. No fixed regimen is provided in public literature.

Safety data for levobupivacaine in pregnancy and lactation are limited. It should be used during pregnancy only when the potential benefit justifies any potential risk to the fetus. Breastfeeding mothers should consult their healthcare provider, as the drug may be excreted in small amounts in breast milk.

To place an order, submit an enquiry on the Levobupivacaina Altan product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and any necessary import documentation.

Levobupivacaina Altan is the S‑enantiomer of bupivacaine, offering a similar duration of action with a lower risk of cardiotoxicity and central nervous system toxicity. Compared with racemic bupivacaine, levobupivacaine provides comparable analgesic efficacy while improving the safety margin, especially in high‑dose or continuous infusion settings.

Levobupivacaina Altan should be stored at 2‑8 °C (refrigerated). Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the container. These conditions help maintain the stability and potency of the solution.

The product is supplied as a sterile solution for injection and is administered by a qualified healthcare professional via epidural, infiltration, intrathecal, or peripheral nerve block techniques. The exact route, volume and concentration are selected based on the clinical indication and the patient’s individual needs.

Serious adverse events include systemic toxicity manifesting as seizures, cardiac arrhythmias, respiratory depression, prolonged motor block, and severe allergic reactions such as anaphylaxis. Early signs of toxicity—such as tinnitus, metallic taste, or visual disturbances—should prompt immediate medical evaluation and supportive care.

Levobupivacaina Altan is contraindicated in patients with known hypersensitivity to levobupivacaine or other amide‑type local anesthetics. It should also be avoided in individuals with severe cardiac conduction disorders, uncontrolled epilepsy, or those receiving other agents that significantly increase the risk of local anesthetic systemic toxicity.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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