Product image of Levobupivacaina Kabi (Levobupivacaine Hydrochloride) supplied by GNH India

Levobupivacaina Kabi

Active Ingredient:
Levobupivacaine Hydrochloride
Origin:
EU

Levobupivacaina Kabi (Levobupivacaine Hydrochloride)

Levobupivacaine, the active ingredient in Levobupivacaina Kabi, is a local anesthetic presented as a sterile solution for epidural use. It provides analgesia for epidural anesthesia, postoperative pain control, and labor analgesia.
GNH India supplies Levobupivacaina Kabi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Italia S.R.L.

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Indications & Clinical Uses

Levobupivacaina Kabi is a local anesthetic used in the epidural pathway to manage pain and provide surgical anesthesia.

  • Epidural anesthesia: produces surgical anesthesia for procedures requiring nerve block via the epidural space.
  • Post‑operative analgesia: delivers effective pain relief after surgery to reduce opioid requirements.
  • Labor analgesia: offers controlled pain management during childbirth while preserving maternal consciousness.

How It Works

  • Levobupivacaine reversibly blocks voltage‑gated sodium channels in neuronal membranes, preventing the initiation and propagation of nerve impulses. This inhibition of sodium influx halts depolarization, resulting in a reversible loss of sensation in the targeted region without affecting surrounding tissues.

Side Effects

Adverse reactions may occur with levobupivacaine administration.

Common Side Effects

  • Hypotension: decreased blood pressure following epidural injection.
  • Bradycardia: slowed heart rate observed during or after dosing.
  • Nausea: feeling of sickness or urge to vomit.
  • Pruritus: localized itching, often around the injection site.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm that can be life‑threatening.
  • Seizures: convulsive activity due to central nervous system toxicity.
  • Respiratory depression: reduced breathing effort requiring ventilatory support.

Precautions & Warnings

When using Levobupivacaina Kabi, clinicians should observe several safety measures.

  • Dose determination: individualized by the anesthesiologist based on patient weight, age, and procedure.
  • Cardiovascular monitoring: continuous observation for hypotension, bradycardia, or arrhythmias.
  • Neurological assessment: watch for signs of spinal cord toxicity or prolonged numbness.
  • Allergy history: confirm no known hypersensitivity to amide‑type local anesthetics.
  • Pregnancy and lactation: use only when the expected benefit justifies potential risk.
  • Store below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Levobupivacaina Kabi may interact with other medications, requiring careful management.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine): increase risk of cardiotoxicity.
  • Beta‑blockers: may exacerbate bradycardia and hypotension.
  • General anesthetics (e.g., propofol): additive central nervous system depression.

Moderate Interactions (Monitor Closely)

  • Opioids: enhanced sedation and respiratory depression.
  • NSAIDs: potential increase in bleeding tendency.
  • Magnesium sulfate: potentiation of neuromuscular blockade.

Frequently Asked Questions

Levobupivacaina Kabi is employed for epidural anesthesia, postoperative analgesia, and labor analgesia. In each case the drug is injected into the epidural space to provide targeted loss of sensation, allowing surgical procedures, post‑surgical pain control, or pain relief during childbirth while the patient remains conscious.

Levobupivacaine works by reversibly blocking voltage‑gated sodium channels on neuronal membranes. This blockade prevents sodium influx, which stops the generation and propagation of action potentials, thereby interrupting nerve signal transmission and producing a reversible loss of sensation in the area supplied by the blocked nerves.

The specific dose of Levobupivacaina Kabi is determined by the prescribing anesthesiologist based on the patient’s age, weight, clinical condition, and the type of procedure. Only a qualified healthcare professional should calculate and administer the appropriate amount.

Safety data for levobupivacaine during pregnancy and lactation are limited. It may be used only when the anticipated benefit to the mother outweighs any potential risk to the fetus or infant, and the decision should be made by the treating physician in consultation with obstetric specialists.

To order Levobupivacaina Kabi, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Levobupivacaina Kabi contains levobupivacaine, the S‑enantiomer of bupivacaine. It offers comparable anesthetic potency with a lower risk of cardiotoxicity and central nervous system toxicity, making it a preferred choice when a safer safety profile is desired for epidural applications.

Levobupivacaina Kabi should be stored below 25 °C in its original packaging, protected from light and moisture. The solution must be kept in a controlled environment and handled only by trained personnel using aseptic techniques to maintain sterility.

The drug is administered by a qualified anesthesiologist or nurse practitioner via epidural injection. A sterile technique is used to place a catheter or needle into the epidural space, and the calculated dose is then delivered slowly to achieve the desired level of analgesia or anesthesia.

Serious risks include cardiac arrhythmias, seizures, severe respiratory depression, and spinal hematoma. These events are rare but require immediate medical attention. Continuous cardiovascular and neurological monitoring during and after administration helps detect and manage such complications promptly.

Levobupivacaina Kabi should be avoided in patients with known hypersensitivity to levobupivacaine or other amide‑type local anesthetics, those with severe cardiac conduction disorders, uncontrolled epilepsy, or significant coagulopathy that increases the risk of spinal bleeding.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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