Product image of Levobupivacaína Altan (Levobupivacaine) supplied by GNH India

Levobupivacaína Altan

Active Ingredient:
Levobupivacaine
Origin:
EU

Levobupivacaína Altan (Levobupivacaine)

Levobupivacaine, the active ingredient in Levobupivacaína Altan, is a local anesthetic presented as a sterile solution for epidural use. It provides regional anesthesia for surgical procedures, postoperative pain management, and labor analgesia in adult patients. Its stereoselective formulation offers a favorable safety profile compared with racemic bupivacaine, allowing effective nerve block with reduced cardiotoxicity.

GNH India supplies Levobupivacaína Altan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Altan Pharmaceuticals S.A.

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Indications & Clinical Uses

Levobupivacaine is employed in epidural anesthesia to manage pain associated with surgery, postoperative recovery, and childbirth.

  • Surgical procedures: provides epidural anesthesia for intra‑operative pain control.
  • Postoperative pain management: maintains analgesia after surgery to facilitate recovery.
  • Labor analgesia: offers effective pain relief during childbirth while preserving maternal consciousness.

How It Works

  • Levobupivacaine produces its anesthetic effect by reversibly binding to voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel and preventing the influx of sodium ions. This blockade inhibits the generation and propagation of nerve impulses, resulting in a loss of sensation in the targeted region without affecting consciousness.

Side Effects

Levobupivacaine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hypotension: decreased blood pressure following epidural block.
  • Bradycardia: slower than normal heart rate.
  • Motor block: temporary weakness in the lower limbs.
  • Nausea: feeling of sickness or urge to vomit.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm that can be life‑threatening.
  • Seizures: uncontrolled electrical activity in the brain.
  • Respiratory depression: reduced breathing effort requiring support.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When using Levobupivacaína Altan, clinicians should observe several safety measures to minimize risk.

  • Patient assessment: evaluate cardiovascular and neurological status before administration.
  • Dose titration: adjust concentration based on patient response and procedure length.
  • Monitoring: continuously observe blood pressure, heart rate, and level of block.
  • Contraindications: avoid in patients with known hypersensitivity to amide local anesthetics.
  • Co‑administration with anticoagulants: assess bleeding risk and consider spinal hematoma.
  • Store at ambient temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levobupivacaine can interact with other medicines, altering its safety or effectiveness.

Major Interactions (Avoid)

  • Concurrent use with other local anesthetics: risk of cumulative systemic toxicity.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma concentrations.
  • Beta‑blockers or calcium channel blockers: can exacerbate bradycardia and hypotension.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may enhance hypotensive effects.
  • Anticoagulants (e.g., heparin, warfarin): increase risk of spinal or epidural hematoma.
  • Central nervous system depressants (e.g., opioids, benzodiazepines): may deepen sedation and respiratory depression.

Frequently Asked Questions

Levobupivacaína Altan is a sterile epidural formulation of levobupivacaine used to provide regional anesthesia for surgical procedures, to control postoperative pain, and to offer analgesia during labor. It is administered by qualified healthcare professionals to achieve a reversible loss of sensation in the targeted area.

Levobupivacaine works by binding reversibly to voltage‑gated sodium channels on nerve membranes, stabilising them in an inactive state. This prevents sodium influx, blocking the initiation and propagation of action potentials, which results in a temporary loss of sensory and motor function in the region supplied by the blocked nerves.

The specific dose and concentration of Levobupivacaína Altan are determined by the prescribing clinician based on the type of procedure, patient characteristics, and desired depth of block. Healthcare providers calculate the appropriate amount according to established clinical guidelines and individual patient needs.

Safety data for levobupivacaine during pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under the supervision of a qualified obstetric or anesthetic specialist.

To order Levobupivacaína Altan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Levobupivacaína Altan contains levobupivacaine, the S‑enantiomer of bupivacaine. Compared with racemic bupivacaine, it offers a similar duration of anesthesia but with a lower incidence of cardiotoxicity and central nervous system toxicity, making it a preferred option when safety margins are a priority.

Store Levobupivacaína Altan at ambient temperature, preferably below 25 °C, in its original packaging. Protect the product from direct light, moisture and extreme temperatures. Inspect the vial for particulate matter or discoloration before use and discard if any abnormalities are observed.

Levobupivacaína Altan is administered by an experienced anesthesiologist or qualified practitioner via epidural injection. The drug is injected into the epidural space using aseptic technique, and the dosage is titrated to achieve the desired level of sensory and motor block while monitoring the patient continuously.

Serious risks include cardiac arrhythmias, severe hypotension, central nervous system toxicity such as seizures, respiratory depression, and rare complications like spinal or epidural hematoma. Prompt recognition and supportive management are essential; therefore, continuous cardiovascular and neurological monitoring is required during and after administration.

Levobupivacaína Altan should be avoided in patients with known hypersensitivity to amide‑type local anesthetics, those with significant cardiac conduction abnormalities, severe heart block, or uncontrolled arrhythmias. Caution is also advised in patients receiving anticoagulant therapy or who have coagulopathies due to the risk of spinal hematoma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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