Product image of Levobupivacaína Altan (Levobupivacaine) supplied by GNH India

Levobupivacaína Altan

Active Ingredient:
Levobupivacaine
Origin:
EU

Levobupivacaína Altan (Levobupivacaine)

Levobupivacaine, the active ingredient in Levobupivacaína Altan, is a local anesthetic (amide) presented as a sterile solution for epidural, infiltration, intrathecal and peripheral nerve block use. It provides reversible loss of sensation for surgical anesthesia, postoperative and labor analgesia, and targeted nerve block procedures.

GNH India supplies Levobupivacaína Altan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Altan Pharmaceuticals S.A.

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Indications & Clinical Uses

Levobupivacaine is employed in the management of pain and anesthesia across several clinical pathways.

  • Surgical anesthesia: produces complete loss of sensation during operative procedures.
  • Post‑operative analgesia: extends pain relief after surgery to improve recovery.
  • Labor analgesia: reduces uterine contraction pain while preserving maternal consciousness.
  • Peripheral nerve blocks for acute or chronic pain: enables targeted analgesia for limb surgeries or chronic pain syndromes.

How It Works

  • Levobupivacaine blocks voltage‑gated sodium channels on neuronal membranes, preventing the influx of sodium ions required for depolarization. This reversible inhibition stops the initiation and propagation of nerve impulses, resulting in loss of sensory and, at higher concentrations, motor function in the targeted area.

Side Effects

Levobupivacaína Altan may cause a range of adverse reactions, which vary in frequency and severity.

Common Side Effects

  • Hypotension: transient drop in blood pressure after administration.
  • Bradycardia: slowed heart rate, especially with high spinal or epidural doses.
  • Dizziness or light‑headedness.
  • Nausea or vomiting.
  • Metallic taste or oral paraesthesia.
  • Injection‑site pain or erythema.

Serious or Rare Side Effects

  • Cardiovascular toxicity: arrhythmias, cardiac arrest, or severe hypotension.
  • Central nervous system toxicity: seizures, convulsions, or loss of consciousness.
  • Allergic reactions: rash, urticaria, or anaphylaxis.
  • Respiratory depression or apnea.
  • Prolonged motor block.
  • Persistent neurologic deficits.

Precautions & Warnings

Levobupivacaína Altan requires careful clinical assessment and monitoring before and during use.

  • Cardiac assessment: evaluate baseline heart function and monitor ECG during administration.
  • Hemodynamic monitoring: observe blood pressure and heart rate for signs of hypotension or bradycardia.
  • Incremental dosing: use fractionated doses to reduce risk of systemic toxicity.
  • Hypersensitivity: avoid in patients with known allergy to amide‑type local anesthetics.
  • Hepatic impairment: adjust dose or avoid if severe liver disease is present.
  • Store at ambient temperature: keep in original packaging, protect from moisture and light.

Avoid Interactions

Levobupivacaína Altan can interact with other drugs that affect cardiac or central nervous system function.

Major Interactions (Avoid)

  • Other local anesthetics: cumulative toxicity may occur.
  • Class I antiarrhythmics (e.g., quinidine, procainamide): increase risk of cardiotoxicity.
  • Beta‑blockers: may enhance bradycardia and hypotension.
  • Calcium channel blockers: can potentiate hypotensive effects.
  • Central nervous system depressants: heightened risk of CNS toxicity.

Moderate Interactions (Monitor Closely)

  • Opioids: additive sedation and respiratory depression.
  • Benzodiazepines: increased CNS depression.
  • Monoamine oxidase inhibitors: potential for hypertensive episodes.

Frequently Asked Questions

Levobupivacaína Altan is a sterile solution of levobupivacaine used as a local anesthetic for surgical anesthesia, postoperative pain control, labor analgesia, and peripheral nerve blocks to manage acute or chronic pain. It is administered by epidural, intrathecal, infiltration or peripheral nerve techniques under the direction of a qualified clinician.

Levobupivacaine blocks voltage‑gated sodium channels on neuronal membranes, preventing sodium influx that is essential for depolarisation. This reversible inhibition stops the generation and propagation of nerve impulses, leading to loss of sensation and, at higher concentrations, motor block in the area supplied by the targeted nerves.

The dose of Levobupivacaína Altan is determined by the prescribing clinician based on the type of procedure, the route of administration, patient weight, age, and comorbidities. Clinicians select an appropriate concentration and volume to achieve the desired anesthetic effect while monitoring for toxicity.

Safety data for levobupivacaine in pregnancy and lactation are limited. It should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and only under close medical supervision. Breastfeeding mothers should consult their healthcare provider before use.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain if required) and assist with import documentation.

Levobupivacaine is the S‑enantiomer of bupivacaine and offers a similar duration of anesthesia with a lower risk of cardiotoxicity and central nervous system toxicity. Both agents provide long‑acting block, but levobupivacaine is often preferred when a safer cardiovascular profile is desired.

Store the product at ambient temperature, preferably below 25 °C, in its original sealed container. Protect it from direct sunlight, moisture and extreme temperatures. Do not freeze. Inspect the vial for particulate matter before use and discard if the solution appears discoloured or contaminated.

Levobupivacaína Altan is administered by a qualified healthcare professional via epidural, intrathecal, infiltration or peripheral nerve block techniques. The solution is injected directly into the target space using aseptic technique, with dose and volume adjusted to the clinical situation and patient response.

The most serious risks include cardiovascular toxicity such as arrhythmias, severe hypotension or cardiac arrest, and central nervous system toxicity including seizures, loss of consciousness, and respiratory depression. Prompt recognition and supportive management are essential if systemic toxicity occurs.

Levobupivacaína Altan should be avoided in patients with known hypersensitivity to amide‑type local anesthetics, those with severe hepatic impairment, uncorrected hypovolemia, or significant cardiac conduction abnormalities. It is also contraindicated when inadvertent intravascular injection cannot be reliably prevented.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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