Product image of Levobupivacaine Altan (Levobupivacaine) supplied by GNH India

Levobupivacaine Altan

Active Ingredient:
Levobupivacaine
Origin:
EU

Levobupivacaine Altan (Levobupivacaine)

Levobupivacaine, the active ingredient in Levobupivacaine Altan, is a local anesthetic (amide) presented as a sterile solution for injection for epidural, infiltration, intrathecal and peripheral nerve block use. It provides reversible blockade of nerve impulse transmission to achieve surgical and obstetric analgesia.

GNH India supplies Levobupivacaine Altan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Altan Pharmaceuticals S.A.

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Indications & Clinical Uses

Levobupivacaine is a local anesthetic used for regional anesthesia and analgesia.

  • Epidural analgesia: provides pain relief during labor or postoperative periods.
  • Infiltration anesthesia for surgical procedures: creates localized numbness for minor surgeries.
  • Intrathecal anesthesia: enables spinal anesthesia for cesarean sections or lower‑limb procedures.
  • Peripheral nerve block: produces targeted anesthesia for limb surgeries.

How It Works

  • Levobupivacaine reversibly binds to voltage‑gated sodium channels on neuronal membranes, stabilizing the inactive state of the channel. This prevents the influx of sodium ions required for depolarization, thereby inhibiting initiation and propagation of nerve impulses and producing a reversible loss of sensation in the targeted area.

Side Effects

Levobupivacaine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hypotension: transient drop in blood pressure.
  • Bradycardia: slowed heart rate.
  • Dizziness or light‑headedness.
  • Nausea or vomiting.
  • Metallic taste in the mouth.
  • Headache at the injection site.

Serious or Rare Side Effects

  • Seizures: central nervous system toxicity.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Respiratory depression: reduced breathing effort.
  • Prolonged motor block: extended loss of muscle function.
  • Allergic reaction: rash, itching, or anaphylaxis.
  • Systemic toxicity: signs of central or cardiovascular toxicity.

Precautions & Warnings

When using Levobupivacaine, clinicians should observe several safety measures.

  • Cardiac monitoring: observe ECG in patients with known heart disease.
  • Hepatic function assessment: adjust use in severe liver impairment.
  • Incremental dosing: avoid large single bolus injections.
  • Aspiration before injection: prevent intravascular administration.
  • Pregnancy caution: limited data; weigh benefits against potential risks.
  • Store at room temperature: keep in original container, protect from light and moisture.

Avoid Interactions

Levobupivacaine can interact with other drugs, affecting safety and efficacy.

Major Interactions (Avoid)

  • Class I antiarrhythmics (e.g., quinidine): increase cardiotoxicity.
  • Beta‑blockers (e.g., propranolol): may exacerbate bradycardia.
  • Other local anesthetics (e.g., bupivacaine): additive systemic toxicity.

Moderate Interactions (Monitor Closely)

  • Opioids (e.g., fentanyl): may potentiate sedation and respiratory depression.
  • NSAIDs (e.g., ketorolac): could increase bleeding tendency.
  • Diuretics (e.g., furosemide): may alter plasma concentration of the anesthetic.

Frequently Asked Questions

Levobupivacaine Altan is used to provide regional anesthesia and analgesia. It is administered via epidural, infiltration, intrathecal or peripheral nerve block techniques to achieve pain control during surgery, obstetric procedures, or postoperative recovery.

Levobupivacaine works by binding to voltage‑gated sodium channels on nerve membranes, stabilizing them in an inactive state. This blocks sodium influx, preventing depolarization and halting the transmission of pain signals, resulting in a reversible loss of sensation in the targeted area.

The dose of Levobupivacaine Altan is determined by the prescribing clinician based on the specific procedure, patient characteristics, and route of administration. Healthcare professionals calculate the appropriate concentration and volume to achieve effective anesthesia while minimizing risk.

Safety data for Levobupivacaine in pregnancy and breastfeeding are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Levobupivacaine Altan, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Levobupivacaine is the S‑enantiomer of bupivacaine and offers a similar duration of anesthesia with a lower risk of cardiotoxicity and central nervous system toxicity. Both are amide‑type local anesthetics, but Levobupivacaine is often preferred when a safer cardiac profile is desired.

Levobupivacaine Altan should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from direct sunlight, moisture and extreme temperatures to maintain stability and potency.

Levobupivacaine is administered by a qualified healthcare professional via injection. Depending on the clinical need, it can be delivered epidurally, infiltratively into tissues, intrathecally into the spinal canal, or as a peripheral nerve block using appropriate aseptic techniques.

The most serious risks include cardiac arrhythmias, severe hypotension, respiratory depression, seizures, and systemic toxicity leading to central nervous system effects. Prompt recognition and supportive management are essential if these adverse events occur.

Levobupivacaine should be avoided in patients with known hypersensitivity to amide‑type local anesthetics, severe cardiac conduction disorders, uncontrolled epilepsy, or in situations where a safer alternative is available. Clinicians must assess each patient’s medical history before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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